Neonatal management and outcomes of prenatally diagnosed CHDs
Abstract
Objectives: The aim of this study was to determine the probability of intervention at birth after prenatal diagnosis of CHD. Methods: A 10-year retrospective study including all foetuses with a prenatally diagnosed CHD and those delivered in a tertiary-care cardiac centre between January, 2002 and December, 2011 was carried out. Patients were classified into eight groups according to the anticipated risk of neonatal intervention. Results: The need for urgent intervention and/or PGE1 infusion within the first 48 hours of life was 47% (n=507/1080): 72% (n=248) for CHD at risk for a Rashkind procedure, 77% (n=72) for CHD with ductal-dependent pulmonary flow, 13% (n=22) for CHD with potentially ductal-dependent pulmonary flow, 94% (n=62) for CHD with ductal-dependent systemic flow, 29% (n=88) for CHD with potentially ductal-dependant systemic flow, 50% (n=4) for total anomalous pulmonary venous connection, and 17% (n=1) for CHD with atrio-ventricular block. In all, 34% of the patients received PGE1 infusion and 21.4% underwent urgent catheter-based or surgical interventions; 10% of patients without anticipated risk (n=10) underwent an early intervention; 6.7% (n=73) of the patients died; and 55% (n=589) had an intervention before discharge from hospital. Conclusion: Half of the neonates with foetal CHD benefited from an urgent intervention or PGE1 infusion at birth. We recommend scheduled delivery and in utero transfer for transposition of the great arteries, double-outlet right ventricle with sub-pulmonary ventricular septal defect, total anomalous pulmonary venous connection, CHD with atrio-ventricular block with heart rate <50, all ductal-dependant lesions, and CHD with potentially ductal-dependant systemic flow.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Prenatal diagnosis of CHD results in improved neonatal outcomes compared with postnatal diagnosis.
“The prenatal diagnosis of CHD is of substantial significance, resulting in improved neonatal outcomes compared with postnatal diagnosis.”
Cites
Detection of Transposition of the Great Arteries in Fetuses Reduces Neonatal Morbidity and Mortality
Bonnet, D., Coltri, A., Butera, G., Fermont, L., Le Bidois, J., Kachaner, J., & Sidi, D. (1999) · Circulation · doi:10.1161/01.cir.99.7.916 · Cited by 760 · see citing works
Self-citationImproved Surgical Outcome After Fetal Diagnosis of Hypoplastic Left Heart Syndrome
Tworetzky, W., McElhinney, D. B., Reddy, V. M., Brook, M. M., Hanley, F. L., & Silverman, N. H. (2001) · Circulation · doi:10.1161/01.cir.103.9.1269 · Cited by 678 · see citing works
Prenatal diagnosis of coarctation of the aorta improves survival and reduces morbidity: Table 1
Franklin, O., Burch, M., Manning, N., Sleeman, K., Gould, S., & Archer, N. (2002) · Heart · doi:10.1136/heart.87.1.67 · Cited by 419 · see citing works
Mahle, W. T., Clancy, R. R., McGaurn, S. P., Goin, J. E., & Clark, B. J. (2001) · Pediatrics · doi:10.1542/peds.107.6.1277 · Cited by 375 · see citing works
Khoshnood, B., De Vigan, C., Vodovar, V., Goujard, J., Lhomme, A., Bonnet, D., & Goffinet, F. (2005) · Pediatrics · doi:10.1542/peds.2004-0516 · Cited by 302 · see citing works
Self-citationHypoplastic Left Heart Syndrome With Intact or Highly Restrictive Atrial Septum
Vlahos, A. P., Lock, J. E., McElhinney, D. B., & van der Velde, M. E. (2004) · Circulation · doi:10.1161/01.cir.0000128690.35860.c5 · Cited by 256 · see citing works
Khoshnood, B., Lelong, N., Houyel, L., Thieulin, A., Jouannic, J., Magnier, S., Delezoide, A., Magny, J., Rambaud, C., Bonnet, D., et al. (2012) · Heart · doi:10.1136/heartjnl-2012-302543 · Cited by 251 · see citing works
Self-citationMorphological and Physiological Predictors of Fetal Aortic Coarctation
Matsui, H., Mellander, M., Roughton, M., Jičínská, H., & Gardiner, H. M. (2008) · Circulation · doi:10.1161/circulationaha.108.787598 · Cited by 177 · see citing works
Hypoplastic Left Heart Syndrome With Atrial Level Restriction in the Era of Prenatal Diagnosis
Glatz, J. A., Tabbutt, S., Gaynor, J. W., Rome, J. J., Montenegro, L. M., Spray, T. L., & Rychik, J. R. (2007) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2007.06.061 · Cited by 160 · see citing works
Calderon, J., Angeard, N., Moutier, S., Plumet, M.-H., Jambaqué, I., & Bonnet, D. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2011.12.036 · Cited by 156 · cited 1× · see citing works
“The improvement in perinatal management of complex CHD also has consequences on neurodevelopmental outcomes of newborns with CHD by reducing the time between birth and surgery and avoiding prolonged cyanosis and acidosis.(31,32) Delivery in a cardiac centre may help reduce this delay.”
BackgroundSelf-citationSpecialized Delivery Room Planning for Fetuses With Critical Congenital Heart Disease
Donofrio, M. T., Levy, R. J., Schuette, J. J., Skurow-Todd, K., Sten, M.-B., Stallings, C., Pike, J. I., Krishnan, A., Ratnayaka, K., Sinha, P., et al. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.11.029 · Cited by 145 · see citing works
JAEGGI, E. T., Hornberger, L. K., Smallhorn, J. F., et al. (2005) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.1919 · Cited by 143 · see citing works
Anderson, B. R., Ciarleglio, A. J., Hayes, D. A., Quaegebeur, J. M., Vincent, J. A., & Bacha, E. A. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.08.1645 · Cited by 133 · see citing works
The echocardiographic diagnosis of totally anomalous pulmonary venous connection in the fetus
Allan, L. D., & Sharland, G. K. (2001) · Heart · doi:10.1136/heart.85.4.433 · Cited by 123 · see citing works
Head, C., Jowett, V., Sharland, G. K., et al. (2005) · Heart · doi:10.1136/hrt.2003.033027 · Cited by 122 · see citing works
Total anomalous pulmonary venous connection: impact of prenatal diagnosis
Seale, A. N., Carvalho, J. S., Gardiner, H. M., et al. (2012) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.11093 · Cited by 112 · see citing works
Fuchs, I. B., Müller, H., Abdul-Khaliq, H., Harder, T., Dudenhausen, J. W., & Henrich, W. (2007) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.3900 · Cited by 101 · see citing works
Volpe, P., Campobasso, G., Stanziano, A., et al. (2006) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.2818 · Cited by 68 · see citing works
Johnson, B. A., & Ades, A. M. (2005) · Clinics in Perinatology · doi:10.1016/j.clp.2005.09.014 · Cited by 67 · see citing works
Gestational age‐specific scoring systems for the prediction of coarctation of the aorta
Gómez‐Montes, E., Herraı̀z, I., Gómez‐Arriaga, P. I., et al. (2014) · Prenatal Diagnosis · doi:10.1002/pd.4452 · Cited by 62 · see citing works
Improved results with single-stage total correction of Taussig–Bing anomaly☆
Alsoufi, B., Cai, S., Williams, W. G., et al. (2007) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2007.11.017 · Cited by 60 · see citing works
Prenatal diagnosis of isolated total anomalous pulmonary venous connection: a series of 10 cases
Laux, D., Fermont, L., Bajolle, F., et al. (2012) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.11186 · Cited by 55 · see citing works
Self-citationMeyer-Wittkopf, M., Rappe, N., Sierra, F., et al. (2000) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.2000.00108.x · Cited by 53 · see citing works
Long-Distance Transports of Newborn Infants with Congenital Heart Disease
Hellström-Westas, L. K., Hanséus, K., Jögi, P., et al. (2001) · Pediatric Cardiology · doi:10.1007/s002460010254 · Cited by 51 · see citing works
Quartermain, M. D., Glatz, A. C., Goldberg, D., Cohen, M. S., Elias, M. D., Tian, Z., & Rychik, J. R. (2012) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.11196 · Cited by 48 · see citing works
Costs of Prenatal Detection of Congenital Heart Disease
Jegatheeswaran, A., Oliveira, C., Batsos, C., Moon‐Grady, A. J., Silverman, N. H., Hornberger, L. K., Coyte, P. C., & Friedberg, M. K. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.07.052 · Cited by 46 · see citing works
Management of the neonate with symptomatic congenital heart disease
Penny, D. J., & Shekerdemian, L. S. (2001) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.84.3.f141 · Cited by 46 · see citing works
Difficult prenatal diagnosis: fetal coarctation.
Buyens, A., Gyselaers, W. J. A., Coumans, A. B. C., Al‐Nasiry, S., Willekes, C., Boshoff, D. E., Frijns, J.-P., & Witters, I. (2012) · Europe PMC (PubMed Central) · Cited by 45 · see citing works
Arya, B., Levasseur, S. M., Woldu, K. L., Glickstein, J. S., Andrews, H., & Williams, I. A. (2013) · Pediatric Cardiology · doi:10.1007/s00246-013-0857-3 · Cited by 37 · see citing works
Anagnostou, K., Messenger, L., Yates, R., & Kelsall, W. (2012) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2011-300488 · Cited by 33 · see citing works
Hoque, T., Richmond, M. E., Vincent, J. A., et al. (2013) · Pediatric Cardiology · doi:10.1007/s00246-012-0625-9 · Cited by 30 · see citing works
Potential of magnetic resonance for imaging the fetal heart
Wielandner, A., Mlczoch, E., Prayer, D., & Berger‐Kulemann, V. (2013) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2013.05.006 · Cited by 27 · see citing works
Loomba, R. S., Chandrasekar, S., Shah, P. H., et al. (2011) · Annals of Pediatric Cardiology · doi:10.4103/0974-2069.84665 · Cited by 25 · see citing works
Simpson, L. L., Harvey-Wilkes, K. B., & D’Alton, M. E. (2000) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(00)70511-4 · Cited by 20 · see citing works
Tuo, G., Volpe, P., Buffi, D., Robertis, V. D., & Marasini, M. (2013) · Congenital Heart Disease · doi:10.1111/chd.12158 · Cited by 16 · see citing works
Prenatally Diagnosed Coarctation: A More Sinister Disease?
McCandless, R. T., Puchalski, M. D., Minich, L. L., et al. (2012) · Pediatric Cardiology · doi:10.1007/s00246-012-0275-y · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Arnaout, R., Curran, L., Zhao, Y., Levine, J. C., Chinn, E., & Moon-Grady, A. J. (2020) · doi:10.1101/2020.06.22.20137786 · Cited by 315 · see citing works
Nurmaini, S., Rachmatullah, M. N., Sapitri, A. I., Darmawahyuni, A., Tutuko, B., Firdaus, F., Partan, R. U., & Bernolian, N. (2021) · Sensors · doi:10.3390/s21238007 · Cited by 81 · see citing works
Impacts of prenatal diagnosis of congenital heart diseases on outcomes
Bonnet, D. (2021) · Translational Pediatrics · doi:10.21037/tp-20-267 · Cited by 69 · see citing works
Self-citationJost, E., Kosian, P., Jimenez Cruz, J., Albarqouni, S., Gembruch, U., Strizek, B., & Recker, F. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12216833 · Cited by 44 · see citing works
“It allows for appropriate counseling for parents, as well as delivery and treatment planning, and, in some cases, even in utero therapy [49].”
Background
- Authors
- Bensemlali, M., Bajolle, F., Laux, D., Parisot, P., Ladouceur, M., Fermont, L., Lévy, M., Le Bidois, J., Raimondi, F., Ville, Y., Salomon, L. J., Boudjemline, Y., & Bonnet, D.
- Affiliations
- Hôpital Necker-Enfants Malades (FR)
- Corresponding author
- Bensemlali, Myriam
- ORCID
- Venue
- Cardiology in the Young
- Publisher
- Cambridge University Press (CUP)
- Published
- 2016-05-26
- Volume
- 27
- Issue
- 2
- Pages
- 344-353
- ISSN
- 1047-9511 (ISSN-L)
- 1467-1107
- OpenAlex
- W2407150449
- Semantic Scholar
- 9c0e5c5e33fff5190537ee2e72b9515025dab0e9
- Cited by
- 31
- References
- 36
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiology in the Young (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
- Health Sciences › Medicine › Surgery › Congenital Anomalies and Fetal Surgery
- Keywords
- congenital heart disease, prenatal diagnosis, neonatal interventions, transposition of the great arteries, double outlet right ventricle, total anomalous pulmonary venous connection, atrioventricular block, Rashkind procedure, neonatal mortality, scheduled delivery, in utero transfer
- MeSH terms
- Adult, Echocardiography, Female, Follow-Up Studies, Heart Defects, Congenital, Humans, Infant, Newborn, Male, Pregnancy, Pregnancy Outcome, Retrospective Studies, Ultrasonography, Prenatal, Outcome Assessment, Health Care, Disease Management, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
