Assessing Effects of Treatment With Lisdexamfetamine Dimesylate for Pediatric ADHD Using a Parental Survey
Abstract
Introduction: Lisdexamfetamine dimesylate (LDX) is a prodrug stimulant approved for the treatment of attention-deficit/hyperactivity disorder (ADHD) in adults and children 6–12 years of age. Parent surveys provide valuable information regarding the impact of ADHD treatments. Methods: Parents of children with ADHD beginning treatment with LDX voluntarily completed surveys through an automated telephone system or the Internet before and 6 weeks after LDX treatment initiation. Prescribing physicians received individual reports of the responses for each survey completed by their patients' parents. All patients whose parents completed both baseline and 6 week surveys were included in the analyses. Subgroup analyses were conducted for those previously treated with medications to treat ADHD, including mixed amphetamine salts-extended release. Results: LDX treatment was associated with a significant decrease in ADHD symptom interference with school activities, family interactions, homework, and social interactions (P<.01; N= 11,576). Parents rated satisfaction with LDX as significantly higher than with their child's previous treatment (P<.01). On average, global improvement, tolerability, convenience, and satisfaction with LDX were all highly rated. Conclusion: Patients treated with LDX showed significant symptom improvement and parents reported significantly greater satisfaction than with prior treatment.
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The efficacy and side-effects of LDX are similar to the other long-acting stimulant preparations.
“The efficacy and side-effects of LDX are similar to the other long-acting stimulant preparations [68-72].”
From Advances in understanding and treating ADHD (2011) · cites this paper as [69]
Cites
Attention-deficit hyperactivity disorder
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Advances in understanding and treating ADHD
Antshel, K. M., Hargrave, T. M., Simonescu, M., Kaul, P., Hendricks, K., & Faraone, S. V. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-72 · Cited by 140 · see citing works
- Authors
- Antonucci, D., Kunins, C., Manos, M., López, F. A., & Kerney, D. L.
- ORCID
- López, Frank A.
- Venue
- CNS Spectrums
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-04
- Volume
- 15
- Issue
- 4
- Pages
- 248-256
- ISSN
- 1092-8529 (ISSN-L)
- 2165-6509
- OpenAlex
- W2415753950
- Cited by
- 6
- References
- 12
- Citations by year
- 2021: 1 · 2014: 1 · 2012: 2
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CNS Spectrums (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- lisdexamfetamine dimesylate, attention deficit hyperactivity disorder, children with ADHD, stimulant medication, parent-reported outcomes, symptom interference, treatment satisfaction, tolerability
- MeSH terms
- Lisdexamfetamine Dimesylate, Attention Deficit Disorder with Hyperactivity, Child, Dextroamphetamine, Female, Health Surveys, Humans, Male, Parents, Pediatrics, Surveys and Questionnaires, Severity of Illness Index, Outcome Assessment, Health Care
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