Sleep Disorders Associated with Parkinson's Disease:Role of Dopamine, Epidemiology, and Clinical Scales of Assessment
Abstract
Sleep dysfunction is common among patients with Parkinson's disease and occurs in approximately two thirds of patients. The problems range from nocturnal issues such as difficulty with sleep initiation, sleep fragmentation, disturbance of circadian rhythm, and rapid eye movement sleep behavior disorder, to daytime problems such as excessive daytime sleepiness. Frequent nighttime awakening and sleep disruption are the most common sleep problems in Parkinson's disease. Dopamine plays an important role in maintaining wakefulness. To improve sleep in Parkinson's disease, it is important to achieve the critical balance of adequate dopaminergic therapy and control of symptoms. Increased dopaminergic agents can cause dyskinesias and painful dystonia, and undertreatment can cause nighttime akinesia, rigidity, and worse quality of sleep. Other nondopaminergic drugs commonly used in Parkinson's disease can also affect sleep. In patients with advanced Parkinson's disease, deep brain stimulation of the subthalamic nucleus has a favorable impact on sleep quality and sleep architecture.
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A variety of sleep disorders may appear in Parkinson's disease with approximately two third of patients affected.
“A variety of sleep disorders may appear with approximately two third of patients affected (Mehta et al. 2008).”
From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Mehta et al. 2008
Cites
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The clinical symptoms of Parkinson's disease.
Sveinbjornsdottir, S. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13691 · Cited by 1,410 · see citing works
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- Authors
- Mehta, S. H., Morgan, J. C., & Sethi, K. D.
- Affiliations
- Augusta University (US)
- Venue
- CNS Spectrums
- Publisher
- Cambridge University Press (CUP)
- Published
- 2008-03
- Volume
- 13
- Issue
- S4
- Pages
- 6-11
- ISSN
- 1092-8529 (ISSN-L)
- 2165-6509
- OpenAlex
- W2148542396
- Cited by
- 53
- References
- 5
- Citations by year
- 2024: 3 · 2023: 2 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 7 · 2012: 3
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CNS Spectrums (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Parkinson's disease, sleep disorders, dopamine, excessive daytime sleepiness, REM sleep behavior disorder, circadian rhythm disruption, sleep fragmentation, dopaminergic therapy, dyskinesia, deep brain stimulation, subthalamic nucleus, sleep architecture
- MeSH terms
- Animals, Antiparkinson Agents, Brain, Dopamine, Humans, Iatrogenic Disease, Parkinson Disease, Surveys and Questionnaires, Dopamine Agents, Subthalamic Nucleus, Sleep Disorders, Intrinsic, Deep Brain Stimulation
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