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Cited by 166Parkinson's Disease Mechanisms and TreatmentsSleep and related disordersRestless Legs Syndrome Research

Sleep Disruption in Parkinson's Disease: Assessment by Continuous Activity Monitoring

van Hilten, Bob·1994·Archives of Neurology
DOI 10.1001/archneur.1994.00540210094018
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Abstract

OBJECTIVE: To assess differences in activity and immobility during sleep between patients with Parkinson's disease (PD) and healthy subjects and to evaluate the relations of clinical variables with the motor activity measures in patients with PD. DESIGN: Survey, case series. SETTING: University hospital outpatient neurology department and urban population in Leiden, the Netherlands. Motor activity was recorded during 6 successive nights at home with a wrist-worn activity monitor. PARTICIPANTS: Eighty-nine patients with PD and 83 age-matched healthy controls. MAIN OUTCOME MEASURES: For each subject, three mean measures reflecting activity or immobility during the nocturnal period were calculated. RESULTS: Compared with the healthy elderly subjects, patients with PD have an elevated nocturnal activity level and an increased proportion of time with movement, indicating a more disturbed sleep. The mean duration of nocturnal immobility periods was similar for both groups. This measure, however, did reflect the self-reported disturbed sleep maintenance in both groups. The daily dose of levodopa or the use of dopamine agonists in patients not receiving levodopa, rather than disease severity, proved to be the best predictors of nocturnal activity. CONCLUSIONS: We hypothesize that in mildly to moderately affected patients with PD, levodopa or dopamine agonists cause sleep disruption by their effects on sleep regulation. In more severely affected patients, the beneficial effects of these drugs on nocturnal disabilities that cause sleep disruption in PD prevail.

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Crossref · 10.1001/archneur.1994.00540210094018

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  • Reduced amplitude of the rest-activity cycle is present in both de novo and more advanced Parkinson's disease patients, and appears to be independent of the intake of dopaminergic medications.

    “This reduced amplitude of the rest-activity cycle is present in both de novo and more advanced patients, and appears to be independent of the intake of dopaminergic medications (Piccini et al., 1991, Placidi et al., 2008, van Hilten et al., 1994, van Hilten et al., 1993, van Hilten et al., 1993).”

    From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as van Hilten et al., 1994

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Authors
van Hilten, B.
Venue
Archives of Neurology
Publisher
American Medical Association (AMA)
Published
1994-09-01
Volume
51
Issue
9
Pages
922
ISSN
0003-9942 (ISSN-L)
DOI
10.1001/archneur.1994.00540210094018
OpenAlex
W2104533643
Cited by
166
References
41
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 8 · 2015: 4 · 2014: 9 · 2013: 10 · 2012: 6
FWCI
1.21
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Epidemiology › Restless Legs Syndrome Research
Keywords
Parkinson's disease, sleep disruption, wrist-worn activity monitors, levodopa, dopamine agonists, sleep maintenance, sleep regulation, disease severity
MeSH terms
Adult, Aged, Aged, 80 and over, Antiparkinson Agents, Female, Humans, Male, Middle Aged, Monitoring, Physiologic, Motor Activity, Movement, Parkinson Disease, Sleep Wake Disorders

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