Cited by 29Sleep and related disordersParkinson's Disease Mechanisms and TreatmentsRestless Legs Syndrome Research

Sleep disturbances in Parkinson's disease patients and management options

Open access
Claassen, Daniel·2011·Nature and Science of Sleep

Abstract

Sleep disturbances are among the most common nonmotor complaints of patients with Parkinson's disease (PD), and can have a great impact on quality of life. These disturbances manifest in a variety of ways; for instance, insomnia, sleep fragmentation, and excessive daytime sleepiness. Sleep-related movement disorders such as restless legs syndrome and periodic leg movements may share a common pathophysiology, and occurrence of rapid eye movement behavior disorder may predate the onset of PD or other synucleinopathies by several years. Medications for PD can have a significant impact on sleep, representing a great challenge to the treating physician. Awareness of the complex relationship between PD and sleep disorders, as well as the varied way in which sleep disturbances appear, is imperative for successful long-term management.

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  • In individuals with PD, sleep-wake symptoms often precede the development of motor or cognitive symptoms and may be useful as a diagnostic biomarker.

    “In individuals with PD, these sleep–wake symptoms often precede the development of motor or cognitive symptoms and may even be useful as a diagnostic biomarker259,260”

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  1. [80]Huete B Varona L Insomnia during treatment with amantadine Rev Neurol 1997 25 148 2062 9528067

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Authors
Claassen, D.
Affiliations
Vanderbilt University (US)
Corresponding author
Claassen, Daniel
Venue
Nature and Science of Sleep
Published
2011-12
Volume
3
Pages
125
ISSN
1179-1608 (ISSN-L)
OpenAlex
W2026413279
Cited by
29
References
108
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2021: 2 · 2020: 2 · 2019: 6 · 2018: 6 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1
FWCI
0.82
Type
journal article
Language
en
Open access
Locations
  • Nature and Science of Sleep (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Epidemiology › Restless Legs Syndrome Research
Keywords
Parkinson's disease, sleep disorders, insomnia, sleep fragmentation, excessive daytime sleepiness, restless legs syndrome, periodic limb movements, REM sleep behavior disorder, synucleinopathies, antiparkinsonian drugs, quality of life, sleep disorder management

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