Sleep disturbances in Parkinson's disease patients and management options
Open accessAbstract
Sleep disturbances are among the most common nonmotor complaints of patients with Parkinson's disease (PD), and can have a great impact on quality of life. These disturbances manifest in a variety of ways; for instance, insomnia, sleep fragmentation, and excessive daytime sleepiness. Sleep-related movement disorders such as restless legs syndrome and periodic leg movements may share a common pathophysiology, and occurrence of rapid eye movement behavior disorder may predate the onset of PD or other synucleinopathies by several years. Medications for PD can have a significant impact on sleep, representing a great challenge to the treating physician. Awareness of the complex relationship between PD and sleep disorders, as well as the varied way in which sleep disturbances appear, is imperative for successful long-term management.
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In individuals with PD, sleep-wake symptoms often precede the development of motor or cognitive symptoms and may be useful as a diagnostic biomarker.
“In individuals with PD, these sleep–wake symptoms often precede the development of motor or cognitive symptoms and may even be useful as a diagnostic biomarker259,260”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [259]
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Flagged first, then by citations
Research works printed but not linked: 1
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Rhythms of life: circadian disruption and brain disorders across the lifespan
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- Authors
- Claassen, D.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Claassen, Daniel
- ORCID
- Claassen, Daniel
- Venue
- Nature and Science of Sleep
- Publisher
- Informa UK Limited
- Published
- 2011-12
- Volume
- 3
- Pages
- 125
- ISSN
- 1179-1608 (ISSN-L)
- PMC
- PMC3630958
- OpenAlex
- W2026413279
- Cited by
- 29
- References
- 108
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2021: 2 · 2020: 2 · 2019: 6 · 2018: 6 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nature and Science of Sleep (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Epidemiology › Restless Legs Syndrome Research
- Keywords
- Parkinson's disease, sleep disorders, insomnia, sleep fragmentation, excessive daytime sleepiness, restless legs syndrome, periodic limb movements, REM sleep behavior disorder, synucleinopathies, antiparkinsonian drugs, quality of life, sleep disorder management
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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