Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment

The Epidemiology of Major Depressive Disorder: Results From the National Comorbidity Survey Replication (NCS-R)

Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988 · see citing works

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633 · see citing works

A Neurotrophic Model for Stress-Related Mood Disorders

Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works

2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain

Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A., & Waku, K. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2437 · Cited by 2,196 · see citing works

The Corticosteroid Receptor Hypothesis of Depression

Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181 · see citing works

Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study

Herkenham, M., Lynn, A., Johnson, M., Melvin, L., de Costa, B., & Rice, K. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00563.1991 · Cited by 2,159 · see citing works

Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993 · see citing works

The endogenous cannabinoid system controls extinction of aversive memories

Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728 · see citing works

Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS

Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605 · see citing works

Limbic-cortical dysregulation: a proposed model of depression

(1997) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.9.3.471 · Cited by 1,585 · see citing works

Role of Endogenous Cannabinoids in Synaptic Signaling

Freund, T. F., Katona, I., & Piomelli, D. (2003) · Physiological Reviews · doi:10.1152/physrev.00004.2003 · Cited by 1,567 · see citing works

The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

Cota, D., Marsicano, G., Tschöp, M. H., Grübler, Y., Flachskamm, C., Schubert, M. I., Auer, D. P., Yassouridis, A., Thöne‐Reineke, C., Ortmann, S., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17725 · Cited by 1,168 · see citing works

Chronic mild stress-induced anhedonia: A realistic animal model of depression

Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160 · cited 4× · see citing works

ENDOCANNABINOID-MEDIATED SYNAPTIC PLASTICITY IN THE CNS

Chevaleyre, V., Takahashi, K. A., & Castillo, P. E. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112834 · Cited by 779 · see citing works

Depression as a risk factor for cardiac mortality and morbidity

Carney, R. M., Freedland, K. E., Miller, G. E., & Jaffe, A. S. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00311-2 · Cited by 746 · see citing works

Regulation of Serotonin1A, Glucocorticoid, and Mineralocorticoid Receptor in Rat and Human Hippocampus: Implications for the Neurobiology of Depression

López, J. F., Chalmers, D. T., Little, K. Y., & Watson, S. J. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00484-8 · Cited by 700 · see citing works

Glucocorticoids, depression, and mood disorders: Structural remodeling in the brain

McEwen, B. S. (2005) · Metabolism · doi:10.1016/j.metabol.2005.01.008 · Cited by 687 · see citing works

Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis

Gobbi, G., Bambico, F. R., Mangieri, R. A., Bortolato, M., Campolongo, P., Solinas, M., Cassano, T., Morgese, M. G., Debonnel, G., Duranti, A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509591102 · Cited by 676 · see citing works

Exploring the association between cannabis use and depression.

Degenhardt, L., Hall, W., & Lynskey, M. (2003) · Addiction · doi:10.1046/j.1360-0443.2003.00437.x · Cited by 587 · see citing works

CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity

Ravinet‐Trillou, C., Delgorge, C., Menet, C., Arnone, M., & Soubrié, P. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802583 · Cited by 583 · see citing works

Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: Relation to hypercortisolism and corticotropin-releasing hormone

Wong, M., Kling, M. A., Munson, P. J., Listwak, S. J., Licinio, J., Prolo, P., Karp, B., McCutcheon, I. E., Geracioti, T. D., DeBellis, M. D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.325 · Cited by 567 · see citing works

Preclinical models: status of basic research in depression

Nestler, E. J., Gould, E., & Manji, H. K. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01405-1 · Cited by 559 · see citing works

The cannabinoid receptors

Howlett, A. C. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00060-6 · Cited by 536 · see citing works

The cannabinoid system and immune modulation

Klein, T., Newton, C. A., Larsen, K. A., Lu, L. D., Perkins, I., Nong, L., & Friedman, H. P. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0303101 · Cited by 524 · see citing works

Endocannabinoid Signaling Negatively Modulates Stress-Induced Activation of the Hypothalamic-Pituitary-Adrenal Axis

Patel, S., Roelke, C. T., Rademacher, D. J., Cullinan, W. E., & Hillard, C. J. (2004) · Endocrinology · doi:10.1210/en.2004-0638 · Cited by 475 · see citing works

Regulatory Changes in Neuroendocrine Stress-Integrative Circuitry Produced by a Variable Stress Paradigm

Herman, J. P., Adams, D. J., & Prewitt, C. M. (2008) · Neuroendocrinology · doi:10.1159/000126839 · Cited by 458 · see citing works

Cannabis Abuse as a Risk Factor for Depressive Symptoms

BOVASSO, G. B. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.12.2033 · Cited by 455 · see citing works

Endocannabinoid Hedonic Hotspot for Sensory Pleasure: Anandamide in Nucleus Accumbens Shell Enhances ‘Liking’ of a Sweet Reward

Mahler, S. V., Smith, K. S., & Berridge, K. C. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301376 · Cited by 377 · see citing works

Downregulation of Endocannabinoid Signaling in the Hippocampus Following Chronic Unpredictable Stress

Hill, M. N., Patel, S., Carrier, E. J., Rademacher, D. J., Ormerod, B. K., Hillard, C. J., & Gorzalka, B. B. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300601 · Cited by 363 · see citing works

Dexamethasone Suppression Tests in Antidepressant Treatment of Melancholia

Greden, J. F. (1983) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790050019002 · Cited by 354 · see citing works

Antidepressant-like Activity of the Fatty Acid Amide Hydrolase Inhibitor URB597 in a Rat Model of Chronic Mild Stress

Bortolato, M., Mangieri, R. A., Fu, J., Kim, J. H., Arguello, O., Duranti, A., Tontini, A., Mor, M., Tarzia, G., & Piomelli, D. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.001 · Cited by 347 · see citing works

Comparative analysis of fatty acid amide hydrolase and cb1 cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling

Egertová, M., Cravatt, B. F., & Elphick, M. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00145-3 · Cited by 347 · see citing works

Cannabinoids Elicit Antidepressant-Like Behavior and Activate Serotonergic Neurons through the Medial Prefrontal Cortex

Bambico, F. R., Katz, N., Debonnel, G., & Gobbi, G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1636-07.2007 · Cited by 325 · see citing works

The DST as a predictor of outcome in depression: a meta-analysis

Ribeiro, S. C. M., Tandon, R., Grunhaus, L. J., & Greden, J. F. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.11.1618 · Cited by 321 · see citing works

Brain Regional Distribution of Endocannabinoids: Implications for Their Biosynthesis and Biological Function

Bisogno, T., Berrendero, F., Ambrosino, G., Cebeira, M., Ramos, J. A., Fernández‐Ruíz, J., & Marzo, V. D. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0254 · Cited by 313 · see citing works

Cytokine imbalance in the pathophysiology of major depressive disorder

Kim, Y., Na, K.-S., Shin, K.-H., Jung, H., Choi, S., & Kim, J.-B. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.03.004 · Cited by 312 · see citing works

Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling

Patel, S., Roelke, C. T., Rademacher, D. J., & Hillard, C. J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03916.x · Cited by 297 · see citing works

Serum Endocannabinoid Content is Altered in Females with Depressive Disorders: A Preliminary Report

Hill, M., Miller, G., Ho, W.-S., Gorzalka, B., & Hillard, C. (2008) · Pharmacopsychiatry · doi:10.1055/s-2007-993211 · Cited by 292 · see citing works

Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats

Xu, Y., Ku, B., Cui, L., Li, X.-J., Barish, P. A., Foster, T. C., & Ogle, W. O. (2007) · Brain Research · doi:10.1016/j.brainres.2007.05.071 · Cited by 288 · see citing works

Chronic Mild Stress and Sucrose Consumption: Validity as a Model of Depression

Forbes, N., Stewart, C. A., Matthews, K., & REID, I. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00305-8 · Cited by 281 · see citing works

Specific alterations of extracellular endocannabinoid levels in the nucleus accumbens by ethanol, heroin, and cocaine self-administration

Caillé, S., Alvarez-Jaimes, L., Polis, I., Stouffer, D. G., & Parsons, L. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4403-06.2007 · Cited by 280 · see citing works

The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions

Tzavara, E. T., Davis, R. J., Perry, K. W., Li, X., Salhoff, C. R., Bymaster, F. P., Witkin, J. M., & Nomikos, G. G. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705100 · Cited by 270 · see citing works

Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol

Hillard, C. J. (2000) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(00)00051-4 · Cited by 255 · see citing works

Effects of the cannabinoid CB1 receptor antagonist rimonabant in models of emotional reactivity in rodents

Griebel, G., Stemmelin, J., & Scatton, B. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.032 · Cited by 253 · see citing works

Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain

Hillard, C. J., Wilkison, D. M., Edgemond, W. S., & Campbell, W. B. (1995) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00087-s · Cited by 233 · see citing works

Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test

Hill, M. N., & Gorzalka, B. B. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.03.003 · Cited by 231 · see citing works

Upregulation of CB1 receptors and agonist-stimulated [35S]GTPγS binding in the prefrontal cortex of depressed suicide victims

Hungund, B. L., Vinod, K. Y., Kassir, S. A., Basavarajappa, B. S., Yalamanchili, R., Cooper, T. B., Mann, J. J., & Arango, V. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001376 · Cited by 226 · see citing works

Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors

Urigüen, L., Pérez-Rial, S., Ledent, C., Palomo, T., & Manzanares, J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.01.003 · Cited by 218 · see citing works

Regulation of endocannabinoid signaling by stress: Implications for stress-related affective disorders

Gorzalka, B. B., Hill, M. N., & Hillard, C. J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.004 · Cited by 211 · see citing works

Requirement of Cannabinoid Receptor Type 1 for the Basal Modulation of Hypothalamic-Pituitary-Adrenal Axis Function

Cota, D., Steiner, M.-A., Marsicano, G., Cervino, C., Herman, J. P., Grübler, Y., Stalla, J., Pasquali, R., Lutz, B., Stalla, G. K., et al. (2007) · Endocrinology · doi:10.1210/en.2005-1649 · Cited by 205 · see citing works

Major Depressive Disorder, Suicidal Ideation, and Suicide Attempt inTwins Discordant for Cannabis Dependence and Early-Onset Cannabis Use

Lynskey, M. T., Glowinski, A. L., Todorov, A. A., Bucholz, K. K., Madden, P. A. F., Nelson, E. C., Statham, D. J., Martin, N. G., & Heath, A. C. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.10.1026 · Cited by 198 · see citing works

Is there a role for the endocannabinoid system in the etiology and treatment of melancholic depression?

Hill, M. N., & Gorzalka, B. B. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00006 · Cited by 193 · see citing works

Lipid signaling: Sleep, synaptic plasticity, and neuroprotection

Chen, C., & Bazan, N. G. (2005) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2005.07.001 · Cited by 193 · see citing works

Cannabinoids potentiate emotional learning plasticity in neurons of the medial prefrontal cortex through basolateral amygdala inputs

Laviolette, S. R., & Grace, A. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0707-06.2006 · Cited by 189 · see citing works

Expression of CB1 cannabinoid receptor in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression

Koethe, D., Llenos, I. C., Dulay, J. R., Hoyer, C., Torrey, Ε. F., Leweke, F. M., & Weis, S. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0660-5 · Cited by 187 · see citing works

Antidepressant-like and anorectic effects of the cannabinoid CB1 receptor inverse agonist AM251 in mice

Shearman, L. P., Rosko, K., Fleischer, R., Wang, J., Xu, S., Tong, X., & Rocha, B. A. G. (2003) · Behavioural Pharmacology · doi:10.1097/00008877-200312000-00001 · Cited by 186 · see citing works

Prefrontal-subcortical and limbic circuit mediation of major depressive disorder

Brody, A. L., Barsom, M. W., Bota, R. G., & Saxena, S. (2001) · Seminars in Clinical Neuropsychiatry · doi:10.1053/scnp.2001.21837 · Cited by 181 · see citing works

Endocannabinoids and Vascular Function

Hillard, C. J. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39035-4 · Cited by 181 · see citing works

Neuromodulatory functions of the endocannabinoid system.

Marsicano, G., & Lutz, B. (2006) · PubMed · Cited by 167 · see citing works

Genetic Impairment of Frontocortical Endocannabinoid Degradation and High Alcohol Preference

Hansson, A. C., Bermúdez‐Silva, F. J., Malinen, H., Hyytiä, P., Sánchez-Vera, I., Rimondini, R., de Fonseca, F. R., Kunos, G., Sommer, W. H., & Heilig, M. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301034 · Cited by 164 · see citing works

Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropinreleasing hormone

Wrong, M. (2000) · Medical Entomology and Zoology · Cited by 159 · see citing works

Reduced sensitivity to reward in CB1 knockout mice

Sanchis‐Segura, C., Cline, B. H., Marsicano, G., Lutz, B., & Spanagel, R. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1877-8 · Cited by 158 · see citing works

Endocannabinoids as cardiovascular modulators

Kunos, G., Járai, Z., Bátkai, S., Goparaju, S. K., Ishac, E. J. N., Liu, J., Wang, L., & Wagner, J. A. (2000) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(00)00194-8 · Cited by 158 · see citing works

Differential Regulation of the Endocannabinoids Anandamide and 2-Arachidonylglycerol within the Limbic Forebrain by Dopamine Receptor Activity

Patel, S., Rademacher, D. J., & Hillard, C. J. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.054270 · Cited by 153 · see citing works

Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice

Steiner, M. A., Marsicano, G., Nestler, E. J., Holsboer, F., Lutz, B., & Wotjak, C. T. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.09.008 · Cited by 142 · see citing works

Estrogen recruits the endocannabinoid system to modulate emotionality.

Hill, M., Karacabeyli, E., & Gorzalka, B. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.02.003 · Cited by 141 · see citing works

Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain

Valenti, M., Vigan�, D., Casico, M. G., Rubino, T., Steardo, L., Parolaro, D., & Marzo, V. D. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3453-5 · Cited by 135 · see citing works

Animal models of depression: are there any?

O'Neil, M. F., & Moore, N. A. (2003) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.496 · Cited by 133 · see citing works

Role of the endocannabinoid system in depression and suicide

Vinod, K. Y., & Hungund, B. L. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.08.006 · Cited by 132 · see citing works

Elevated levels of endocannabinoids and CB1 receptor-mediated G-protein signaling in the prefrontal cortex of alcoholic suicide victims

Vinod, K. Y., Arango, V., Xie, S., Kassir, S. A., Mann, J. J., Cooper, T. B., & Hungund, B. L. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.033 · Cited by 127 · see citing works

Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice

Steiner, M. A., Wanisch, K., Monory, K., Marsicano, G., Borroni, E., Bächli, H., Holsboer, F., Lutz, B., & Wotjak, C. T. (2007) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500466 · Cited by 123 · see citing works

The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity

Patel, S., Carrier, E. J., Ho, W. ‐. V., Rademacher, D. J., Cunningham, S., Reddy, D. S., Falck, J. R., Cravatt, B. F., & Hillard, C. J. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400377-jlr200 · Cited by 123 · see citing works

Functional classification of antidepressants based on antagonism of swim stress-induced fos-like immunoreactivity.

Duncan, G. E., Knapp, D. J., Johnson, K. B., & Breese, G. R. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12895-4 · Cited by 117 · see citing works

Involvement of the Endocannabinoid System in the Ability of Long-Term Tricyclic Antidepressant Treatment to Suppress Stress-Induced Activation of the Hypothalamic–Pituitary–Adrenal Axis

Hill, M. N., Ho, W. ‐. V., Sinopoli, K. J., Viau, V., Hillard, C. J., & Gorzalka, B. B. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301092 · Cited by 116 · see citing works

Enhancement of anxiety-like responsiveness to the cannabinoid CB1 receptor agonist HU-210 following chronic stress

Hill, M. N., & Gorzalka, B. B. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.06.069 · Cited by 114 · see citing works

A therapeutic role for cannabinoid CB1 receptor antagonists in major depressive disorders

Witkin, J. M., Tzavara, E. T., Davis, R. J., Li, X., & Nomikos, G. G. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.10.006 · Cited by 110 · see citing works

The endogenous cannabinoid receptor ligand, anandamide, inhibits the motor behavior: role of nigrostriatal dopaminergic neurons

Romero, J., Garcia, L., Cebeira, M., Zadrozny, D., Fernández‐Ruíz, J., & Ramos, J. A. (1995) · Life Sciences · doi:10.1016/0024-3205(95)00186-a · Cited by 108 · see citing works

Sexual Dysfunction in Major Depression

Williams, K., & Reynolds, M. F. (2006) · CNS Spectrums · doi:10.1017/s1092852900026729 · Cited by 107 · see citing works

Arachidonoyl ethanolamide-[1,2-14C] as a substrate for anandamide amidase

Omeir, R. L., Chin, S. A., Hong, Y. H., Ahern, D. G., & Deutsch, D. G. (1995) · Life Sciences · doi:10.1016/0024-3205(95)00181-5 · Cited by 99 · see citing works

Prolonged glucocorticoid treatment decreases cannabinoid CB 1 receptor density in the hippocampus

Hill, M. N., Carrier, E. J., Ho, W. ‐. V., Shi, L., Patel, S., Gorzalka, B. B., & Hillard, C. J. (2007) · Hippocampus · doi:10.1002/hipo.20386 · Cited by 96 · see citing works

Endocannabinoid Metabolic Pathways and Enzymes

Ligresti, A., Cascio, M. G., & Marzo, V. D. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/156800705774933104 · Cited by 81 · see citing works

Characterization of Ligand Binding to the Cannabinoid Receptor of Rat Brain Membranes Using a Novel Method: Application to Anandamide

Hillard, C. J., Edgemond, W. S., & Campbell, W. B. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64020677.x · Cited by 80 · see citing works

Interactions between endocannabinoids and stress-induced decreased sensitivity to natural reward

Rademacher, D. J., & Hillard, C. J. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.12.013 · Cited by 79 · see citing works

CB1 knockout mice display impaired functionality of 5‐HT1A and 5‐HT2A/C receptors

Mato, S., Aso, E., Castro, E., Martín, M., Valverde, O., Maldonado, R. J., & Pazos, Á. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04961.x · Cited by 79 · see citing works

Antidepressive Treatment with Amitriptyline and Paroxetine: Effects on Saliva Cortisol Concentrations

Deuschle, M., Hamann, B., Meichel, C., Krumm, B., Lederbogen, F., Kniest, A., Colla, M., & Heuser, I. (2003) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200304000-00014 · Cited by 77 · see citing works

Brain monoamine receptors in a chronic unpredictable stress model in rats

Ossowska, G., Nowak, G., Kata, R., Klenk-Majewska, B., Danilczuk, Z., & Żebrowska-Łupina, I. (2001) · Journal of Neural Transmission · doi:10.1007/s007020170077 · Cited by 76 · see citing works

Enhancement of endocannabinoid signaling and the pharmacotherapy of depression

Mangieri, R. A., & Piomelli, D. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.09.003 · Cited by 71 · see citing works

Differential regulation of corticotropin-releasing factor1 receptor expression by stress and agonist treatments in brain and cultured cells.

Iredale, P. A., Terwilliger, R. Z., Widnell, K. L., Nestler, E. J., & Duman, R. S. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09538-0 · Cited by 67 · see citing works

Chronic mild stress and depressive disorder: a useful new model?

Reid, I., Forbes, N., Stewart, C. A., & Matthews, K. (1997) · Psychopharmacology · doi:10.1007/s002130050471 · Cited by 58 · see citing works

Effects of antidepressants on monoamine transporters

Langer, S. Z., & Schoemaker, H. E. (1988) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(88)90037-1 · Cited by 58 · see citing works

Melatonin protects against the effects of chronic stress on sexual behaviour in male rats

Brotto, L. A., Gorzalka, B. B., & LaMarre, A. K. (2001) · Neuroreport · doi:10.1097/00001756-200111160-00018 · Cited by 56 · see citing works

Time course of opioid and cannabinoid gene transcription alterations induced by repeated administration with fluoxetine in the rat brain

Oliva, J. M., Urigüen, L., Pérez-Rial, S., & Manzanares, J. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.04.014 · Cited by 50 · see citing works

Electroconvulsive shock treatment differentially modulates cortical and subcortical endocannabinoid activity

Hill, M. N., Barr, A. M., Ho, W. ‐. V., Carrier, E. J., Gorzalka, B. B., & Hillard, C. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04688.x · Cited by 49 · see citing works

Regulation of axonal development by plasma membrane gangliosides

Abad‐Rodríguez, J., & Robotti, A. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04713.x · Cited by 28 · see citing works

Effect of imipramine on brain D-1 and 5-HT-2A receptors in a chronic unpredictable stress model in rats.

Ossowska, G., Nowak, G., Klenk-Majewska, B., Danilczuk, Z., & Zebrowska-Łupina, I. (2002) · PubMed · Cited by 21 · see citing works

P.3.033 Acute and chronic stress alter cannabinoid CB1 receptor function and POMC gene expression in the rat brain

Pérez-Rial, S., Urigüen, L., Palomo, T., & Manzanares, J. (2004) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(04)80413-9 · Cited by 2 · see citing works

P.2.d.016 Effects of combined administration of a selective inhibitor of the FAAH (URB597) and imipramine or citalopram in the forced swimming test in rats

Filip, M., Frankowska, M., Wydra, K., Nowak, E., & McCreary, A. C. (2006) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(06)70387-x · Cited by 1 · see citing works

Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders

(2000) · doi:10.1002/1520-6394(2000)12:1+

The endocannabinoid system and the brain.

Mechoulam, R., & Parker, L. A. (2013) · Annual Review of Psychology · doi:10.1146/annurev-psych-113011-143739 · Cited by 1,090 · see citing works

Neurobiological Interactions Between Stress and the Endocannabinoid System

Morena, M., Patel, S., Bains, J. S., & Hill, M. N. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.166 · Cited by 663 · see citing works

Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?

Hillard, C. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.130 · Cited by 449 · see citing works

Neurobiology of chronic mild stress: parallels to major depression

Hill, M. N., Hellemans, K. G. C., Verma, P., Gorzalka, B. B., & Weinberg, J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.001 · Cited by 420 · see citing works

Antidepressant‐like effects of cannabidiol in mice: possible involvement of 5‐HT_1Areceptors

Zanelati, T., Biojone, C., Moreira, F., Guimarães, F., & Joca, S. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00521.x · Cited by 366 · see citing works

Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: A positron emission tomography study

Neumeister, A., Normandin, M. D., Pietrzak, R. H., Piomelli, D., Zheng, M. Q., Gujarro-Anton, A., Potenza, M. N., Bailey, C. R., Lin, S. F., Najafzadeh, S., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.61 · Cited by 361 · see citing works

Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic–pituitary–adrenal axis

Hill, M. N., McLaughlin, R. J., Morrish, A. C., Viau, V., Floresco, S. B., Hillard, C. J., & Gorzalka, B. B. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.114 · Cited by 304 · see citing works

Neuroplasticity Underlying the Comorbidity of Pain and Depression

Doan, L., Manders, T. R., & Wang, J. (2015) · Neural Plasticity · doi:10.1155/2015/504691 · Cited by 284 · see citing works

Functional Interactions between Stress and the Endocannabinoid System: From Synaptic Signaling to Behavioral Output

Hill, M. N., Patel, S., Campolongo, P., Tasker, J. G., Wotjak, C. T., & Bains, J. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4283-10.2010 · Cited by 255 · see citing works

Differential effects of chronic unpredictable stress on hippocampal CB1 receptors in male and female rats

Reich, C. G., Taylor, M. E., & McCarthy, M. M. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.05.013 · Cited by 244 · see citing works

Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder

Hill, M. N., Campolongo, P., Yehuda, R., & Patel, S. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.162 · Cited by 239 · see citing works

Reinforcement learning in depression: a review of computational research

Chen, C., Takahashi, T., Nakagawa, S., Inoue, T., & Kusumi, I. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.005 · Cited by 233 · see citing works

Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure

Hill, M. N., Kumar, S. A., Filipski, S. B., Iverson, M., Stuhr, K. L., Keith, J. M., Cravatt, B. F., Hillard, C. J., Chattarji, S., & McEwen, B. S. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.90 · Cited by 222 · see citing works

The anxiolytic effects of cannabidiol in chronically stressed mice are mediated by the endocannabinoid system: Role of neurogenesis and dendritic remodeling

Fogaça, M. V., Campos, A. C., Coelho, L. D., Duman, R. S., & Guimarães, F. S. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.03.001 · Cited by 208 · see citing works

Depression‐resistant endophenotype in mice overexpressing cannabinoid CB ₂ receptors

García‐Gutiérrez, M., Pérez‐Ortiz, J., Gutiérrez‐Adán, A., & Manzanares, J. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00819.x · Cited by 196 · see citing works

Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence

Hillard, C. J., Weinlander, K. M., & Stuhr, K. L. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.020 · Cited by 186 · see citing works

Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors

Serrano, A., & Parsons, L. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.06.005 · Cited by 180 · see citing works

The Therapeutic Potential of the Endocannabinoid System for the Development of a Novel Class of Antidepressants

Hill, M. N., Hillard, C. J., Bambico, F. R., Patel, S., Gorzalka, B. B., & Gobbi, G. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.06.006 · Cited by 172 · see citing works

Endocannabinoid system, stress and HPA axis

Micale, V., & Drago, F. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.07.039 · Cited by 189 · see citing works

Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System

McPartland, J. M., Guy, G. W., & Marzo, V. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089566 · Cited by 161 · see citing works

Abnormal reward functioning across substance use disorders and major depressive disorder: Considering reward as a transdiagnostic mechanism

Baskin-sommers, A. R., & Foti, D. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.01.011 · Cited by 155 · see citing works

The endocannabinoid system and psychiatric disorders

Parolaro, D., Realini, N., Viganò, D., Guidali, C., & Rubino, T. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.03.018 · Cited by 150 · see citing works

Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation

Wang, M., Hill, M. N., Zhang, L., Gorzalka, B. B., Hillard, C. J., & Alger, B. E. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111409606 · Cited by 137 · see citing works

Stress regulates endocannabinoid-CB1 receptor signaling

Hillard, C. J. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.04.001 · Cited by 136 · see citing works

Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects

Marco, E. M. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00063 · Cited by 136 · see citing works

Endocannabinoid System Components as Potential Biomarkers in Psychiatry

Navarrete, F., García‐Gutiérrez, M. S., Barba, R. J., Rubio, G., Gasparyan, A., Austrich-Olivares, A., & Manzanares, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00315 · Cited by 134 · see citing works

A critical role for prefrontocortical endocannabinoid signaling in the regulation of stress and emotional behavior

McLaughlin, R. J., Hill, M. N., & Gorzalka, B. B. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.006 · Cited by 130 · see citing works

Alterations in Corticolimbic Dendritic Morphology and Emotional Behavior in Cannabinoid CB1 Receptor-Deficient Mice Parallel the Effects of Chronic Stress

Hill, M. N., Hillard, C. J., & McEwen, B. S. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq280 · Cited by 127 · see citing works

Deficiency in Endocannabinoid Signaling in the Nucleus Accumbens Induced by Chronic Unpredictable Stress

Wang, W., Sun, D., Pan, B., Roberts, C. J., Sun, X., Hillard, C. J., & Liu, Q.-S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.99 · Cited by 124 · see citing works

Endocannabinoid signals in the control of emotion

Lutz, B. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.12.001 · Cited by 124 · see citing works

Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants

Gorzalka, B. B., & Hill, M. N. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.11.021 · Cited by 118 · see citing works

CB1 Cannabinoid Receptor Signaling and Biased Signaling

Leo, L. M., & Abood, M. E. (2021) · Molecules · doi:10.3390/molecules26175413 · Cited by 117 · see citing works

Translational evidence for the involvement of the endocannabinoid system in stress-related psychiatric illnesses

Hill, M. N., & Patel, S. (2013) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-3-19 · Cited by 117 · see citing works

Animal models of post-traumatic stress disorder and recent neurobiological insights

Whitaker, A. M., Gilpin, N. W., & Edwards, S. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000069 · Cited by 110 · see citing works

The endocannabinoid system and the regulation of neural development: potential implications in psychiatric disorders

Galve‐Roperh, I., Palazuelos, J., Aguado, T., & Guzmán, M. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-009-0028-y · Cited by 110 · see citing works

Long Term Sex-Dependent Psychoneuroendocrine Effects of Maternal Deprivation and Juvenile Unpredictable Stress in Rats

Llorente, R., Miguel-Blanco, C., Aisa, B., Lachize, S., Borcel, É., Meijer, O. C., Ramírez, M. J., de Kloet, E. R., & Viveros, M. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02109.x · Cited by 101 · see citing works

Physical exercise and depression

Rot, M. A. H., Collins, K. A., & Fitterling, H. (2009) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20094 · Cited by 99 · see citing works

Sex-dependent alterations in response to maternal deprivation in rats

Viveros, M., Llorente, R., López‐Gallardo, M., Suárez, J., Bermúdez‐Silva, F. J., la Fuente, M. D., de Fonseca, F. R., & García‐Segura, L. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.015 · Cited by 99 · see citing works

Dysfunction in Fatty Acid Amide Hydrolase Is Associated with Depressive-Like Behavior in Wistar Kyoto Rats

Vinod, K. Y., Xie, S., Psychoyos, D., Hungund, B. L., Cooper, T. B., & Tejani‐Butt, S. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036743 · Cited by 97 · see citing works

Mechanism of Repetitive Transcranial Magnetic Stimulation for Depression.

Peng, Z., Zhou, C., Xue, S., Bai, J., Yu, S.-F., Li, X., Wang, H., & Tan, Q. (2018) · Europe PMC (PubMed Central) · doi:10.11919/j.issn.1002-0829.217047 · Cited by 96 · see citing works

Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice

Umathe, S. N., Manna, S. S. S., & Jain, N. S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.031 · Cited by 96 · see citing works

Antidepressant‐like effects of fenofibrate in mice via the hippocampal brain‐derived neurotrophic factor signalling pathway

Jiang, B., Wang, Y., Wang, H., Song, L., Huang, C., Zhu, Q., Wu, F., & Zhang, W. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13668 · Cited by 96 · see citing works

Endocannabinoid-mediated synaptic plasticity and addiction-related behavior

Sidhpura, N., & Parsons, L. H. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.05.034 · Cited by 92 · see citing works

Cannabinoid CB1 receptors in the medial prefrontal cortex modulate the expression of contextual fear conditioning

Lisboa, S. F. D. S., dos Reis, D. G., da Silva, A. L., Corrêa, F. M. D. A., Guimarães, F. S., & Resstel, L. B. M. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000684 · Cited by 91 · see citing works

Recent Progress in Understanding the Pathophysiology of Post-Traumatic Stress Disorder: Implications for Targeted Pharmacological Treatment

Bailey, C. R., Cordell, E., Sobin, S. M., & Neumeister, A. (2013) · CNS Drugs · doi:10.1007/s40263-013-0051-4 · Cited by 89 · see citing works

Sex differences in the chronic mild stress model of depression

Franceschelli, A., Herchick, S., Thelen, C., Papadopoulou‐Daifoti, Z., & Pitychoutis, P. M. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000062 · Cited by 89 · see citing works

Endocannabinoid-mediated modulation of stress responses: Physiological and pathophysiological significance

Finn, D. P. (2009) · Immunobiology · doi:10.1016/j.imbio.2009.05.011 · Cited by 88 · see citing works

Brain CB2 Receptors: Implications for Neuropsychiatric Disorders

Roche, M., & Finn, D. P. (2010) · Pharmaceuticals · doi:10.3390/ph3082517 · Cited by 87 · see citing works

The effects of trauma on brain and body: A unifying role for the midbrain periaqueductal gray

Terpou, B. A., Harricharan, S., McKinnon, M. C., Frewen, P., Jetly, R., & Lanius, R. A. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24447 · Cited by 82 · see citing works

Cannabinoids and emotionality: a neuroanatomical perspective

McLaughlin, R. J., & Gobbi, G. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.052 · Cited by 82 · see citing works

Endocannabinoid Signaling in the Etiology and Treatment of Major Depressive Illness

Hillard, C. J., & Liu, Q.-S. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660735 · Cited by 79 · see citing works

Endocannabinoids: Effectors of glucocorticoid signaling

Balsevich, G., Petrie, G. N., & Hill, M. N. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.07.005 · Cited by 78 · see citing works

Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents

Hill, M. N., Ho, W.-S. V., Hillard, C. J., & Gorzalka, B. B. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0131-7 · Cited by 75 · see citing works

Translational evidence for a role of endocannabinoids in the etiology and treatment of posttraumatic stress disorder

Neumeister, A., Seidel, J., Ragen, B., & Pietrzak, R. H. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.012 · Cited by 76 · see citing works

2-Arachidonoylglycerol Modulation of Anxiety and Stress Adaptation: From Grass Roots to Novel Therapeutics

Bedse, G., Hill, M. N., & Patel, S. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.01.015 · Cited by 75 · see citing works

Anti-depressive mechanism of repetitive transcranial magnetic stimulation in rat: the role of the endocannabinoid system.

Wang, H.-N., Wang, L., Zhang, R.-G., Chen, Y.-C., Liu, L., Gao, F., Nie, H., Hou, W.-G., Peng, Z., & Tan, Q.-R. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.01.004 · Cited by 70 · see citing works

Endocannabinoids and Mental Disorders

Rubino, T., Zamberletti, E., & Parolaro, D. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-20825-1_9 · Cited by 71 · see citing works

Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review

Hasbi, A., Madras, B. K., & George, S. R. (2023) · Brain Sciences · doi:10.3390/brainsci13020325 · Cited by 68 · see citing works

Altered CB1receptor‐signaling in prefrontal cortex from an animal model of depression is reversed by chronic fluoxetine

Rodríguez‐Gaztelumendi, A., Rojo, M. L., Pazos, Á., & Díaz, Á. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05898.x · Cited by 68 · see citing works

Upregulation of CB1 receptor binding in the ventromedial prefrontal cortex promotes proactive stress-coping strategies following chronic stress exposure

McLaughlin, R. J., Hill, M. N., Dang, S. S., Wainwright, S. R., Galea, L. A. M., Hillard, C. J., & Gorzalka, B. B. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.09.053 · Cited by 65 · see citing works

Crosstalk between endocannabinoid and immune systems: a potential dysregulation in depression?

Boorman, E., Zajkowska, Z., Ahmed, R., Pariante, C. M., & Zunszain, P. A. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4105-9 · Cited by 66 · see citing works

Age of stress exposure modulates the immediate and sustained effects of repeated stress on corticolimbic cannabinoid CB1 receptor binding in male rats

Lee, T. T. Y., & Hill, M. N. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.11.017 · Cited by 67 · see citing works

Animal models of post-traumatic stress disorder and novel treatment targets

Aspesi, D., & Pinna, G. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000467 · Cited by 65 · see citing works

Chronic, noninvasive glucocorticoid administration suppresses limbic endocannabinoid signaling in mice

Bowles, N. P., Hill, M. N., Bhagat, S. M., Karatsoreos, I. N., Hillard, C. J., & McEwen, B. S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.048 · Cited by 63 · see citing works

Cannabinoid Modulation of the Stressed Hippocampus

Scarante, F. F., Vila-Verde, C., Lopes, V. D., Ferreira‐Junior, N. C., Guimarães, F. S., & Campos, A. C. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00411 · Cited by 64 · see citing works

Long-Term Fluoxetine Treatment Modulates Cannabinoid Type 1 Receptor-Mediated Inhibition of Adenylyl Cyclase in the Rat Prefrontal Cortex through 5-Hydroxytryptamine1A Receptor-Dependent Mechanisms

Mato, S., Vidal, R., Castro, E., Díaz, Á., Pazos, Á., & Valdizán, E. M. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.060079 · Cited by 63 · see citing works

Endocannabinoid signaling in the amygdala: anatomy, synaptic signaling, behavior, and adaptations to stress

Ramikie, T. S., & Patel, S. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.037 · Cited by 62 · see citing works

Early life stress alters the developmental trajectory of corticolimbic endocannabinoid signaling in male rats

Hill, M. N., Eiland, L. R., Lee, T. T.-Y., Hillard, C. J., & McEwen, B. S. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.036 · Cited by 62 · see citing works

Antidepressants and Changes in Concentration of Endocannabinoids and N-Acylethanolamines in Rat Brain Structures

Smaga, I., Bystrowska, B., Gawliński, D., Pomierny, B., Stankowicz, P., & Filip, M. (2014) · Neurotoxicity Research · doi:10.1007/s12640-014-9465-0 · Cited by 61 · see citing works

Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial prefrontal cortex 5-HT1A and CB1 receptors

Malvestio, R. B., de Medeiros, P. S., Negrini-Ferrari, S. E., Oliveira-Silva, M., Medeiros, A. C., Padovan, C. M., Luongo, L., Maione, S., Coimbra, N. C., & de Freitas, R. L. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.06.017 · Cited by 60 · see citing works

High Times for Painful Blues: The Endocannabinoid System in Pain-Depression Comorbidity

Fitzgibbon, M., Finn, D. P., & Roche, M. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv095 · Cited by 57 · see citing works

The Endocannabinoid System and Anxiety

Lisboa, S. F. D. S., Gomes, F. V., Terzian, A. L. B., de Aguiar, D. C., Moreira, F. A., Resstel, L. B. M., & Guimarães, F. S. (2016) · Vitamins and hormones · doi:10.1016/bs.vh.2016.09.006 · Cited by 56 · see citing works

Maternal separation increases alcohol-drinking behaviour and reduces endocannabinoid levels in the mouse striatum and prefrontal cortex

Portero-Tresserra, M., Gracia-Rubio, I., Cantacorps, L., Pozo, O. J., Gómez-Gómez, A., Pastor, A., López-Arnau, R., de la Torre, R., & Valverde, O. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.02.003 · Cited by 55 · see citing works

Cannabinoids in depressive disorders

Poleszak, E., Wośko, S., Sławińska, K., Szopa, A., Wróbel, A., & Serefko, A. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.09.058 · Cited by 55 · see citing works

Down and High: Reflections Regarding Depression and Cannabis

Langlois, C. C., Potvin, S., Khullar, A., & Tourjman, V. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.625158 · Cited by 51 · see citing works

Reductions in circulating endocannabinoid 2-arachidonoylglycerol levels in healthy human subjects exposed to chronic stressors

Yi, B., Ничипорук, И. А., Nicolas, M., Schneider, S., Feuerecker, M., Vassilieva, G. Y., Thieme, D., Schelling, G., & Choukèr, A. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.01.004 · Cited by 51 · see citing works

Schizophrenia and depression, two poles of endocannabinoid system deregulation

Rodríguez-Muñoz, M., Sánchez‐Blázquez, P., Callado, L. F., Meana, J. J., & Garzón-Niño, J. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0029-y · Cited by 52 · see citing works

Chronic stress differentially regulates cannabinoid CB1 receptor binding in distinct hippocampal subfields

Hill, M. N., Hunter, R. G., & McEwen, B. S. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.04.048 · Cited by 48 · see citing works

Role of the Endocannabinoid System in Depression: from Preclinical to Clinical Evidence

Micale, V., Tabiová, K., Kučerová, J., & Drago, F. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2294-9_5 · Cited by 47 · see citing works

Depression, Selective Serotonin Reuptake Inhibitors, and Osteoporosis

Bab, I., & Yirmiya, R. (2010) · Current Osteoporosis Reports · doi:10.1007/s11914-010-0026-z · Cited by 46 · see citing works

Adolescent chronic mild stress alters hippocampal CB1 receptor-mediated excitatory neurotransmission and plasticity

Reich, C. G., Mihalik, G. R., Iskander, A. N., Seckler, J. C., & Weiss, M. S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.066 · Cited by 46 · see citing works

Abnormalities in neuroendocrine stress response in psychosis: the role of endocannabinoids

Appiah‐Kusi, E., Leyden, E., Parmar, S. R., Mondelli, V., McGuire, P. K., & Bhattacharyya, S. (2015) · Psychological Medicine · doi:10.1017/s0033291715001786 · Cited by 45 · see citing works

Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance

Balsevich, G., Sticht, M. A., Bowles, N. P., Singh, A., Lee, T. T.-Y., Li, Z., Chelikani, P. K., Lee, F. S., Borgland, S. L., Hillard, C. J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802251115 · Cited by 46 · see citing works

Endocannabinoid System Alterations in Posttraumatic Stress Disorder: A Review of Developmental and Accumulative Effects of Trauma

Nia, A. B., Bender, R. L., & Harpaz‐Rotem, I. (2019) · Chronic Stress · doi:10.1177/2470547019864096 · Cited by 47 · see citing works

Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology

Rodrigues, R., Lourenço, D., Paulo, S., Mateus, J., Ferreira, M. A., Mouro, F. M., Moreira, J. B., Ribeiro, F., Sebastião, A., & Xapelli, S. (2019) · Molecules · doi:10.3390/molecules24071350 · Cited by 44 · see citing works

A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy

Eisenstein, S. A., Clapper, J. R., Holmes, P. V., Piomelli, D., & Hohmann, A. G. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2009.12.013 · Cited by 45 · see citing works

Changes in the Brain Endocannabinoid System in Rat Models of Depression

Smaga, I., Jastrzębska, J., Zaniewska, M., Bystrowska, B., Gawliński, D., Faron‐Górecka, A., Broniowska, Ż., Miszkiel, J., & Filip, M. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9708-y · Cited by 44 · see citing works

Molecular Alterations of the Endocannabinoid System in Psychiatric Disorders

Navarro, D., Gasparyan, A., Navarrete, F., Torregrosa, A. B., Rubio, G., Marín, M., Acosta, G. B., García‐Gutiérrez, M. S., & Manzanares, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094764 · Cited by 45 · see citing works

Depression and bone mass

Bab, I., & Yirmiya, R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05218.x · Cited by 42 · see citing works

New Perspectives on the Use of Cannabis in the Treatment of Psychiatric Disorders

Scherma, M., Masia, P., Deidda, M. L., Fratta, W., Tanda, G., & Fadda, P. (2018) · Medicines · doi:10.3390/medicines5040107 · Cited by 41 · see citing works

Endocannabinoid reactivity to acute stress: Investigation of the relationship between salivary and plasma levels

Ney, L. J., Stone, C., Nichols, D. S., Felmingham, K. L., Bruno, R., & Matthews, A. J. (2021) · Biological Psychology · doi:10.1016/j.biopsycho.2021.108022 · Cited by 41 · see citing works

Endocannabinoid Regulation of Neuroendocrine Systems

Tasker, J. G., Chen, C., Fisher, M. O., Fu, X., Rainville, J. R., & Weiss, G. L. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.09.003 · Cited by 41 · see citing works

Anandamide reverses depressive-like behavior, neurochemical abnormalities and oxidative-stress parameters in streptozotocin-diabetic rats: Role of CB1 receptors

Morais, H., de Souza, C. P., da Silva, L. M., Ferreira, D. M., Baggio, C. H., Vanvossen, A. C., de Carvalho, M. C., da Silva‐Santos, J. E., Bertoglio, L. J., da Cunha, J. M., et al. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.08.007 · Cited by 40 · see citing works

Early exposure to environmental enrichment alters the expression of genes of the endocannabinoid system

Rawas, R. E., Thiriet, N., Nader, J., Lardeux, V., Jaber, M., & Solinas, M. (2011) · Brain Research · doi:10.1016/j.brainres.2011.03.025 · Cited by 40 · see citing works

The Endocannabinoid/Endovanilloid System and Depression

Smaga, I., Bystrowska, B., Gawliński, D., Przegaliński, E., & Filip, M. (2014) · Current Neuropharmacology · doi:10.2174/1570159x12666140923205412 · Cited by 39 · see citing works

Sex-dimorphism in human serum endocannabinoid and n-acyl ethanolamine concentrations across the lifespan

Hamzah, K. A., Toms, L.-M. L., Kucharski, N., Orr, J. S., Turner, N. P., Hobson, P., Nichols, D. S., & Ney, L. J. (2023) · Scientific Reports · doi:10.1038/s41598-023-50426-4 · Cited by 35 · see citing works

Relationships between serotonergic and cannabinoid system in depressive‐like behavior: a PET study with [11C]‐ DASB

Burokas, A., Martín‐García, E., Cuesta, J., Rojas, S., Herance, J. R., Gispert, J. D., Serra, M., & Maldonado, R. J. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12716 · Cited by 38 · see citing works

The fatty acid amide hydrolase inhibitor URB597 modulates serotonin-dependent emotional behaviour, and serotonin1A and serotonin2A/C activity in the hippocampus

Bambico, F. R., Duranti, A., Nóbrega, J. N., & Gobbi, G. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.12.027 · Cited by 38 · see citing works

Cannabinoid modulation of chronic mild stress-induced selective enhancement of trace fear conditioning in adolescent rats

Reich, C. G., Iskander, A. N., & Weiss, M. S. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113499207 · Cited by 38 · see citing works

Sex-dependent influence of chronic mild stress (CMS) on voluntary alcohol consumption; study of neurobiological consequences

Marco, E. M., Ballesta, J. A., Irala, C., Hernández, M.-D., Navacerrada, M. E. S., Mela, V., López‐Gallardo, M., & Viveros, M. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.11.005 · Cited by 36 · see citing works

The endocannabinoid system as a novel target in the pathophysiology and treatment of depressive illness

Hill, M. N. (2009) · cIRcle (University of British Columbia) · doi:10.14288/1.0066984

Changes in the cannabinoids receptors in rats following treatment with antidepressants

Smaga, I., Zaniewska, M., Gawliński, D., Faron‐Górecka, A., Szafrański, P. W., Cegla, M. T., & Filip, M. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.08.012 · Cited by 30 · see citing works

A possible role for the endocannabinoid system in the neurobiology of depression

Serra, G., & Fratta, W. (2007) · Clinical Practice and Epidemiology in Mental Health · doi:10.1186/1745-0179-3-25 · Cited by 51 · see citing works

Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants

Gorzalka, B. B., & Hill, M. N. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.11.021 · Cited by 118 · see citing works

Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents

Hill, M. N., Ho, W.-S. V., Hillard, C. J., & Gorzalka, B. B. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0131-7 · Cited by 75 · see citing works