Linguistic changes in verbal expression: A preclinical marker of Alzheimer's disease
Open accessAbstract
Despite the many studies examining linguistic deterioration in Alzheimer's disease (AD), very little is known about changes in verbal expression during the preclinical phase of this disease. The objective of this study was to determine whether changes in verbal expression occur in the preclinical phase of AD. The sample consisted of 40 healthy Spanish speakers from Antioquia, Colombia. A total of 19 were carriers of the E280A mutation in the Presenilin 1 gene, and 21 were noncarrier family members. The two groups were similar in age and education. All the participants were shown the Cookie Theft Picture Card from the Boston Diagnostic Aphasia Examination and were asked to describe the scene. Specific grammatical and semantic variables were evaluated. The performance of each group was compared using multivariate analyses of the variance for semantic and grammatical variables, and errors. Carriers of the mutation produced fewer semantic categories than noncarriers. In the preclinical phase of AD, changes in verbal expression are apparent and early detection of these differences may assist the early diagnosis of and intervention in this disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some of these linguistic deficits may occur preclinically in each of these neurodegenerative disorders.
“Some of these deficits may actually occur preclini cally in each of these disorders. 3,33-36”
From Speech and language markers of neurodegeneration: a call for global equity (2023) · cites this paper as [33]
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Moms, J. C., Heyman, A., Mohs, R. C., Hughes, J. P., van Belle, G., Fillenbaum, G., Mellits, E. D., & Clark, C. (1989) · Neurology · doi:10.1212/wnl.39.9.1159 · Cited by 4,130 · see citing works
The assessment of aphasia and related disorders
Goodglass, H., & Kaplan, E. (1972) · Medical Entomology and Zoology · Cited by 3,258 · see citing works
Snowdon, D. A. (1996) · JAMA · doi:10.1001/jama.1996.03530310034029 · Cited by 696 · see citing works
Alzheimer Disease and Associated Disorders
Post, S. G., & Whitehouse, P. J. (1992) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199205000-00001 · Cited by 461 · see citing works
Stability of the preclinical episodic memory deficit in Alzheimer's disease
Bäckman, L., Small, B. J., & Fratiglioni, L. (2001) · Brain · doi:10.1093/brain/124.1.96 · Cited by 449 · see citing works
Communication and Cognition in Normal Aging and Dementia
Bayles, K. A., Kaszniak, A. W., & Tomoeda, C. K. (1987) · Medical Entomology and Zoology · Cited by 398 · see citing works
Small, B. J., Fratiglioni, L., Viitanen, M., Winblad, B., & Bäckman, L. (2000) · Archives of Neurology · doi:10.1001/archneur.57.6.839 · Cited by 329 · see citing works
Empty Speech in Alzheimer's Disease and Fluent Aphasia
Nicholas, M. L., Obler, L. K., Albert, M. L., & Helm‐Estabrooks, N. (1985) · Journal of Speech Language and Hearing Research · doi:10.1044/jshr.2803.405 · Cited by 304 · see citing works
The effects of very early Alzheimer's disease on the characteristics of writing by a renowned author
Garrard, P. (2004) · Brain · doi:10.1093/brain/awh341 · Cited by 281 · see citing works
Language disintegration in dementia: Effects of etiology and severity
Hier, D. B., Hagenlocker, K., & Shindler, A. G. (1985) · Brain and Language · doi:10.1016/0093-934x(85)90124-5 · Cited by 279 · see citing works
Forbes-McKay, K. E., & Venneri, A. (2005) · Neurological Sciences · doi:10.1007/s10072-005-0467-9 · Cited by 261 · see citing works
Rapp, M. A., & Reischies, F. M. (2005) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200502000-00007 · Cited by 206 · see citing works
Cognitive predictors of incident Alzheimer's disease: A prospective longitudinal study.
Small, B. J., Herlitz, A., Fratiglioni, L., Almkvist, O., & al, E. (1997) · Neuropsychology · doi:10.1037//0894-4105.11.3.413 · Cited by 182 · see citing works
Snowdon, D. A., Greiner, L. H., & Markesbery, W. R. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06347.x · Cited by 148 · see citing works
LANGE, K. L., BONDI, M. W., SALMON, D. P., GALASKO, D., DELIS, D. C., THOMAS, R. G., & THAL, L. J. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617702870096 · Cited by 129 · see citing works
Cognitive predictors of incident Alzheimer's disease: A prospective longitudinal study.
Small, B. J., Herlitz, A., Fratiglioni, L., et al. (1997) · Neuropsychology · doi:10.1037/0894-4105.11.3.413 · Cited by 124 · see citing works
Common Pattern of Language Impairment in Vascular Dementia and in Alzheimer Disease
Vuorinen, E., Laine, M., & Rinne, J. O. (2000) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200004000-00005 · Cited by 116 · see citing works
Forbes‐McKay, K., Ellis, A. W., Shanks, M. F., & Venneri, A. (2005) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2005.01.008 · Cited by 108 · see citing works
Estévez-González, A., García‐Sánchez, C., Boltes, A., Otermín, P., Pascual‐Sedano, B., Gironell, A., & Kulisevsky, J. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000076355 · Cited by 98 · see citing works
Distinct Patterns of Spontaneous Speech Deterioration: An Early Predictor of Alzheimer's Disease
Forbes‐McKay, K., Venneri, A., & Shanks, M. F. (2002) · Brain and Cognition · doi:10.1006/brcg.2001.1377 · Cited by 95 · see citing works
Rapp, M. A. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.2.134 · Cited by 87 · see citing works
Longitudinal effects of Alzheimer disease on discourse production.
Tomoeda, C. K., & Bayles, K. A. (1993) · PubMed · Cited by 75 · see citing works
Jacobson, M. W., Delis, D. C., Bondi, M. W., & Salmon, D. P. (2002) · Neuropsychology · doi:10.1037//0894-4105.16.2.132 · Cited by 73 · see citing works
Comparison between Oral and Written Spelling in Alzheimer's Disease
Croisile, B., Brabant, M.-J., Carmoi, T., et al. (1996) · Brain and Language · doi:10.1006/brln.1996.0081 · Cited by 53 · see citing works
Jacobson, M. W., Delis, D. C., Bondi, M. W., et al. (2002) · Neuropsychology · doi:10.1037/0894-4105.16.2.132 · Cited by 52 · see citing works
Semantic abilities in dementia of the Alzheimer type. II. Grammatical semantics
Smith, S. R. (1989) · Brain and Language · doi:10.1016/0093-934x(89)90084-9 · Cited by 37 · see citing works
Impaired verbal description ability assessed by the Picture Description Task in Alzheimer's disease
Shimada, M., Meguro, K., Yamazaki, H., Horikawa, A., Hayasaka, C., Yamaguchi, S., Yamaguchi, K., Katsuyama, N., Nakano, M., & Yamadori, A. (1998) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(98)00099-5 · Cited by 27 · see citing works
Semenza, C., Borgo, F., Mondini, S., et al. (2000) · Brain and Cognition · doi:10.1006/brcg.1999.1136 · Cited by 22 · see citing works
Edwards, J. K., Larson, E. B., Hughes, J. P., & Kukull, W. A. (1991) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1991.tb02493.x · Cited by 20 · see citing works
The taxonomic perspective: The neuropsychological diagnosis of dementia
Venneri, A., Turnbull, O., & DELLASALA, S. (1996) · Cited by 14 · see citing works
La atención sostenida en la fase preclínica de la enfermedad de Alzheimer
González, A. E., Sánchez, C. G., Alandri, A. B., et al. (2003) · Revista de Neurología · doi:10.33588/rn.3609.2002613 · Cited by 12 · see citing works
Proper names in the early stages of Alzheimer\\'s disease
SEMENZA, C., F, B., S, M., et al. (1999) · ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) · Cited by 12 · see citing works
[Verbal fluency and Alzheimer's disease].
Alberca, R., Salas, D., Pérez-Gil, J. A., et al. (1999) · PubMed · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Connected Speech in Neurodegenerative Language Disorders: A Review
Boschi, V., Catricalà, E., Consonni, M., Chesi, C., Moro, A., & Cappa, S. F. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00269 · Cited by 362 · see citing works
Mueller, K. D., Hermann, B., Mecollari, J., & Turkstra, L. S. (2018) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2018.1446513 · Cited by 336 · see citing works
More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration
Lane-Donovan, C., Philips, G. T., & Herz, J. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.005 · Cited by 158 · see citing works
Speech and language markers of neurodegeneration: a call for global equity
García, A. M., de Leon, J., Tee, B. L., Blasi, D. E., & Gorno-Tempini, M. L. (2023) · Brain · doi:10.1093/brain/awad253 · Cited by 102 · see citing works
Orimaye, S. O., Wong, J. S.-M., & Wong, C. P. (2018) · PLOS ONE · doi:10.1371/journal.pone.0205636 · Cited by 52 · see citing works
Ivanova, O., Martínez‐Nicolás, I., & Meilán, J. J. G. (2024) · International Journal of Language & Communication Disorders · doi:10.1111/1460-6984.12888 · Cited by 38 · see citing works
Speech Processing Approach for Diagnosing Dementia in an Early Stage
Sadeghian, R., Schaffer, J. D., & Zahorian, S. A. (2017) · Interspeech 2017 · doi:10.21437/interspeech.2017-1712 · Cited by 40 · see citing works
Neurodegenerative Disorders of Speech and Language: Non-language-dominant Diseases
García, A. M., DeLeon, J., & Tee, B. L. (2022) · Encyclopedia of Behavioral Neuroscience, 2nd edition · doi:10.1016/b978-0-12-819641-0.00042-6 · Cited by 10 · see citing works
- Authors
- CUETOS, F., ARANGO-LASPRILLA, J. C., URIBE, C., VALENCIA, C., & LOPERA, F.
- Affiliations
- Universidad de Oviedo (ES)
- Universidad de Antioquia (CO)
- Venue
- Journal of the International Neuropsychological Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2007-03-20
- Volume
- 13
- Issue
- 3
- Pages
- 433-439
- ISSN
- 1355-6177 (ISSN-L)
- 1469-7661
- OpenAlex
- W2101435558
- Cited by
- 102
- References
- 34
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 8 · 2023: 12 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 13 · 2018: 8 · 2017: 7 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- www.cambridge.org/core/terms (unspecified)
- Locations
- Journal of the International Neuropsychological Society (publishedVersion)
- PubMed (publishedVersion)
- Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
- Repositorio Digital - Academia Colombiana de Ciencias Exactas, Fisicas y Naturales (submittedVersion)
- Funders
- National Academy of Neuropsychology
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, preclinical Alzheimer's disease, verbal expression, language impairment, presenilin 1, semantic categories, grammatical errors, early diagnosis, picture description, Spanish speakers
- MeSH terms
- Adult, Alzheimer Disease, Female, Humans, Language Tests, Linguistics, Male, Middle Aged, Neuropsychological Tests, Verbal Behavior, Multivariate Analysis, Presenilin-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
