CoChat
Sign Up
Cited by 132Multiple Sclerosis Research StudiesDementia and Cognitive Impairment ResearchCancer-related cognitive impairment studies

The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.

Cognitive reserve moderates the negative effect of brain atrophy on cognitive efficiency in multiple sclerosis

SUMOWSKI, JAMES F., CHIARAVALLOTI, NANCY, WYLIE, GLENN, DELUCA, JOHN·2009·Journal of the International Neuropsychological Society
DOI 10.1017/s1355617709090912
Open this paper in CoChat — free account

Abstract

According to the cognitive reserve hypothesis, neuropsychological expression of brain disease is attenuated among persons with higher education or premorbid intelligence. The current research examined cognitive reserve in multiple sclerosis (MS) by investigating whether the negative effect of brain atrophy on information processing (IP) efficiency is moderated by premorbid intelligence. Thirty-eight persons with clinically definite MS completed a vocabulary-based estimate of premorbid intelligence (Wechsler Vocabulary) and a composite measure of IP efficiency (Symbol Digit Modalities Test and Paced Auditory Serial Addition Task). Brain atrophy was estimated from measurements of third ventricle width using high-resolution anatomical brain magnetic resonance imaging (magnetization-prepared rapid gradient echo). In a hierarchical regression analysis controlling for age and depressive symptomatology, brain atrophy predicted worse IP efficiency (R2 = .23, p = .003) and cognitive reserve predicted better IP efficiency (R2 = .13, p = .013), but these effects were moderated by an Atrophy x Cognitive Reserve interaction (R2 = .15, p = .004). The negative effect of brain atrophy on IP efficiency was attenuated at higher levels of reserve, such that MS subjects with higher reserve were better able to withstand MS neuropathology without suffering cognitive impairment. Results help explain the incomplete and inconsistent relationship between brain atrophy and IP efficiency in previous res…

Overview

Integrity signals

Registry

Crossref · 10.1017/s1355617709090912

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 4

  1. 10.1097/00002093-200607001-00010 · DOI · Paper page
  2. Smith, 1982, Symbol Digit Modalities Test manual
  3. Lezak, 2004, Neuropsychological assessment
  4. Rao, 1990, A manual for the Brief Repeatable Battery of Neuropsychological Tests in multiple sclerosis

Cited by

Sorted by citations

See all 132

Related

See all

Metadata

Authors
SUMOWSKI, J. F., CHIARAVALLOTI, N., WYLIE, G., & DELUCA, J.
Affiliations
Kessler Foundation (US)
Corresponding author
SUMOWSKI, JAMES F.
ORCID
Venue
Journal of the International Neuropsychological Society
Publisher
Cambridge University Press (CUP)
Published
2009-07
Volume
15
Issue
4
Pages
606-612
ISSN
  • 1355-6177 (ISSN-L)
  • 1469-7661
DOI
10.1017/s1355617709090912
OpenAlex
W2090481814
Cited by
132
References
50
Citations by year
2026: 4 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 10 · 2017: 6 · 2016: 15 · 2015: 11 · 2014: 11 · 2013: 16 · 2012: 10
FWCI
6.06
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified)
Locations
  • Journal of the International Neuropsychological Society (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of Cambridge
Topics
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords
cognitive reserve, multiple sclerosis, brain atrophy, processing efficiency, premorbid intelligence, third ventricle width, cognitive impairment, moderation, Symbol Digit Modalities Test, Paced Auditory Serial Addition Test
MeSH terms
Adolescent, Adult, Atrophy, Brain, Cognition Disorders, Female, Humans, Intelligence, Male, Middle Aged, Multiple Sclerosis, Neuropsychological Tests, Regression Analysis, Vocabulary, Models, Statistical, Imaging, Three-Dimensional, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review