Visuospatial, Visuoperceptual, and Visuoconstructive Abilities in Congenital Hypothyroidism
Abstract
Individuals with congenital hypothyroidism (CH), even those diagnosed and treated early, experience selective cognitive deficits, the most striking of which involves the visuocognitive domain. However, the range and nature of their visuocognitive disturbances is not fully understood. We assessed a range of higher-order visuocognitive abilities in 19 children and adolescents with CH and 19 age- and sex-matched typically developing peers (TD) using a battery of neuropsychological tests and a novel self-report measure of sense of direction. CH scored lower than TD on direct tests of visuocognitive function (judging line orientation, parts-to-whole localization, copying three-dimensional block towers, discriminating designs, and matching unfamiliar faces in ¾ profile-view) as well as on self-reported problems in spatial ability. Visuocognitive problems were not global as CH and TD did not differ at copying two-dimensional block designs, mentally rotating and matching abstract shapes, or at matching unfamiliar front-view faces, design features, or designs that engaged either figure-ground segregation, visual constancy, or closure. Early and concurrent thyroid stimulating hormone (TSH) levels were associated with visuocognitive ability, although attention and working memory were not. Individuals with CH exhibit selective visuocognitive weaknesses, some of which are related to early and concurrent TSH levels. (JINS, 2013, 19, 1–9)
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- Authors
- Simic, N., Khan, S., & Rovet, J.
- Affiliations
- Hospital for Sick Children (CA)
- University of Toronto (CA)
- ORCID
- Rovet, Joanne
- Venue
- Journal of the International Neuropsychological Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2013-10-15
- Volume
- 19
- Issue
- 10
- Pages
- 1119-1127
- ISSN
- 1355-6177 (ISSN-L)
- 1469-7661
- OpenAlex
- W2123253863
- Cited by
- 28
- References
- 49
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 2
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the International Neuropsychological Society (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Keywords
- congenital hypothyroidism, visuoperception, visuoconstruction, spatial ability, sense of direction, thyroid-stimulating hormone, thyroid hormone replacement, children and adolescents, face matching, figure-ground segregation, visual constancy, closure, mental rotation, working memory, attention
- MeSH terms
- Adolescent, Attention, Child, Developmental Disabilities, Cognition Disorders, Congenital Hypothyroidism, Female, Humans, Male, Memory, Short-Term, Neuropsychological Tests, Orientation, Perceptual Disorders, Photic Stimulation, Space Perception, Thyroid Hormones, Visual Acuity, Case-Control Studies, Statistics, Nonparametric
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