An examination of regional cerebral blood flow during object naming tasks
Abstract
The purpose of this study was to examine regional cerebral blood flow using positron emission tomography (PET) during the performance of tasks related to visual confrontation naming. Ten healthy, young participants were scanned twice in each of 5 conditions; blood flow was measured using standard PET [15O]-water technology. Two major findings have replicated previous studies. First, the naming of visually presented objects, whether covert or overt, requires a region of the left inferior cortex including the fusiform gyrus. Second, during overt naming, there is an increase in activity in the inferior or frontal cortex and insula as a consequence of generating speech code. These data are consistent with other studies demonstrating the importance of the inferior temporal regions for semantic processing, and the frontal cortex for word form generation.
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The left anterior insula is activated during overt picture naming.
“This explained why the left anterior insula was activated during a range of tasks including overt picture naming (Price et al., 1996b; Zelkowicz et al., 1998; Etard et al., 2000).”
From A review and synthesis of the first 20years of PET and fMRI studies of heard speech, spoken language and reading (2012) · cites this paper as Zelkowicz et al., 1998
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Imaging Cognition II: An Empirical Review of 275 PET and fMRI Studies
Cabeza, R., & Nyberg, L. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/08989290051137585 · Cited by 3,598 · see citing works
Price, C. J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.04.062 · Cited by 2,159 · see citing works
The spatial and temporal signatures of word production components
Indefrey, P., & Levelt, W. J. M. (2004) · Cognition · doi:10.1016/j.cognition.2002.06.001 · Cited by 2,144 · see citing works
Abrahams, S., Goldstein, L. H., Simmons, A., Brammer, M. J., Williams, S. C. R., Giampietro, V. P., Andrew, C. M., & Leigh, P. N. (2003) · Human Brain Mapping · doi:10.1002/hbm.10126 · Cited by 258 · see citing works
Barch, D. M., Sabb, F. W., Carter, C. S., Braver, T. S., Noll, D. C., & Cohen, J. D. (1999) · NeuroImage · doi:10.1006/nimg.1999.0500 · Cited by 186 · see citing works
- Authors
- Zelkowicz, B. J., Herbster, A. N., Nebes, R. D., Mintun, M. A., & Becker, A. J. T.
- Affiliations
- University of Pittsburgh Medical Center (US)
- Venue
- Journal of the International Neuropsychological Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 1998-03
- Volume
- 4
- Issue
- 2
- Pages
- 160-166
- ISSN
- 1355-6177 (ISSN-L)
- 1469-7661
- OpenAlex
- W2145333931
- Cited by
- 66
- References
- 0
- Citations by year
- 2025: 2 · 2023: 1 · 2021: 2 · 2016: 3 · 2014: 4 · 2012: 2
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the International Neuropsychological Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p30mh049815-05, 5k02mh000177-09, 5r01ag013669-03)
- Medical Center, University of Pittsburgh
- National Institute on Aging (AG13669)
- National Institute of Mental Health (MH 49815, K02-MH0177)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- regional cerebral blood flow, object naming, fusiform gyrus, inferior temporal cortex, left inferior frontal cortex, insula, semantic processing, 15O-water PET
- MeSH terms
- Adult, Cerebrovascular Circulation, Female, Humans, Male, Psychomotor Performance, Tomography, Emission-Computed, Visual Perception
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