Determinants of compliance with iron supplementation among pregnant women in Senegal

Seck, Binetou C; Jackson, Robert T

doi:10.1017/s1368980007000924

Cited by 154Medication Adherence and ComplianceGlobal Maternal and Child HealthPublic Health and Nutrition

Determinants of compliance with iron supplementation among pregnant women in Senegal

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Seck, Binetou C, Jackson, Robert T·2008·Public Health Nutrition

DOI 10.1017/s1368980007000924

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Abstract

Background: Community iron supplementation programmes for pregnant women have lacked effectiveness, partly because of low compliance. Objective: To determine factors that influence compliance among pregnant women in Senegal. Design: Two hundred and twenty-one pregnant women, recruited from six health centres in Dakar during their first prenatal visit, were randomly assigned to receive either a prescription to purchase iron/folic acid tablets (control, n = 112) to be taken daily, according to official policy, or to receive free tablets (treatment, n = 109). Compliance was assessed 20 weeks after enrolment through interviews and pill count. Women with low or high compliance (<70% or ≥70%) were asked to explain what influenced their adherence to supplementation. Results: Overall compliance was 69%; it was significantly higher in the treatment than in the control group (86% vs. 48%; P < 0.0001). Women with high compliance (58%) were motivated by: (1) the perception of improved health upon taking the tablets (treatment = 24%, control = 10%); (2) the insistence by midwives that they take the tablets; and (3) the mention that the tablets would improve health. Women with low compliance (42%) reported: (1) the experience of side-effects that they associated with the tablets (treatment = 13%, control = 14%); (2) misunderstanding that they needed to continue taking the tablets throughout pregnancy (treatment = 0%, control = 18%); and (3) forgetfulness. Conclusion: Compliance with iron/folic acid supplementation in Senegal can be increased by providing women with clear instructions about tablet intake and educating them on the health benefits of the tablets.

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Side-effect is frequently considered as a major obstacle to compliance.
“Side-effect is frequently considered as a major obstacle to compliance.”
From Coverage, compliance and factors associated with utilization of iron supplementation during pregnancy in eight rural districts of Ethiopia: a cross-sectional study (2014) · cites this paper as [26]

Iron status during pregnancy: setting the stage for mother and infant
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Galloway, R., & McGuire, J. (1994) · Social Science & Medicine · doi:10.1016/0277-9536(94)90135-x · Cited by 277 · see citing works

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“Seck BC, Jackson RT: Determinants of compliance with iron supplementation among pregnant women in Senegal.”
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“According to studies conducted in the Philippines [14], Senegal [15], and India [16], it was reported as a reason for missing doses of iron-folate supplementation among pregnantmothers by 20.”
BackgroundResultInfluential
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Keats, E., Haider, B. A., Tam, E., & Bhutta, Z. A. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004905.pub6 · Cited by 92 · see citing works
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“compliance and adherence of pregnant women to the iron and folic acid supplementation [11-16].”
Background
Magnitude and factors associated with adherence to Iron-folic acid supplementation among pregnant women in Eritrean refugee camps, northern Ethiopia
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“Pregnant women who reported that they took at least 70% of the expected dose of the IFA tablets in the previous two weeks before the data collection, which is equivalent to consuming at least five tablets per week, were considered as adhered to IFA supplementation, and the opposite is true for non-adherence [15, 17, 1…”
Background
High Adherence to Iron/Folic Acid Supplementation during Pregnancy Time among Antenatal and Postnatal Care Attendant Mothers in Governmental Health Centers in Akaki Kality Sub City, Addis Ababa, Ethiopia: Hierarchical Negative Binomial Poisson Regression
Gebreamlak, B., Dadi, A. F., & Atnafu, A. (2017) · PLOS ONE · doi:10.1371/journal.pone.0169415 · Cited by 80 · see citing works
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“Conversely, higher levels of adherence to iron supplements has been reported in Nigeria and Senegal of 88 and 58% respectively [5, 7].”
Background
Social determinants of iron supplementation among women of reproductive age: a systematic review of qualitative data
Nagata, J. M., Gatti, L. R., & Barg, F. K. (2011) · Maternal and Child Nutrition · doi:10.1111/j.1740-8709.2011.00338.x · Cited by 65 · see citing works
“For instance, study respondents reported fearing iron supplements because they believed they may lead to miscarriage (Ghanekar et al., 2002), a big baby (Ejidokun, 2000, Galloway et al., 2002, Ghanekar et al., 2002), or harm to their baby (Seck and Jackson, 2008).”
BackgroundInfluential
Compliance with iron folic acid and associated factors among pregnant women through pill count in Hawassa city, South Ethiopia: a community based cross-sectional study
Kassa, Z. Y., Awraris, T., Daba, A. K., & Tenaw, Z. (2019) · Reproductive Health · doi:10.1186/s12978-019-0679-8 · Cited by 68 · see citing works
“But lower than the study done in Senegal 69% through pill count [27].”
Background
Organoleptic Properties, Ease of Use, and Perceived Health Effects Are Determinants of Acceptability of Micronutrient Supplements among Poor Mexican Women
Young, S. L., Blanco, I., Hernández‐Cordero, S., Pelto, G. H., & Neufeld, L. M. (2010) · Journal of Nutrition · doi:10.3945/jn.109.113498 · Cited by 53 · see citing works
“The relatively greater acceptability of tablets among women in this study may seem surprising given the low compliance with consumption found in other studies (6,9,13) and reported barriers to tablet use, including perceived adverse effects (10,13,25).”
Result
Compliance with Iron-folic acid (IFA) therapy among pregnant women in an urban area of South India
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Role of family support and women’s knowledge on pregnancy-related risks in adherence to maternal iron–folic acid supplementation in Indonesia
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“reasons for women not taking Fe tablets as recommended is forgetfulness((7,8,20,38)).”
BackgroundResultInfluential
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“As with other studies [18,24,31], we found the lack of awareness of the benefits of IFA supplements, lack of knowledge to continue the supplements or feeling better and stopping the supplementation were also considered as barriers to the use of IFA supplements.”
BackgroundResultInfluential
Individual and Facility-Level Determinants of Iron and Folic Acid Receipt and Adequate Consumption among Pregnant Women in Rural Bihar, India
Wendt, A., Stephenson, R., Young, M., Webb-Girard, A., Hogue, C., Ramakrishnan, U., & Martorell, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120404 · Cited by 59 · see citing works
“It is also possible that the presence of IFA at antenatal care visits improved IFA counseling, which may have increased IFA compliance, as suggested by a study in Senegal[20].”
BackgroundResultInfluential
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“The main reasons for low compliance were the experience of side effects, the misunderstanding of the treatment duration, and oversight.(39)”
T rial of feasibility and acceptability of routine low-dose aspirin versus E arly S creening T est indicated aspirin for pre-eclampsia prevention ( TEST study): a multicentre randomised controlled trial
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“These reasons are similar to the findings from Senegal [7] Nepal [17] and Mali [14].”
BackgroundResult
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How can formative research inform the design of an iron-folic acid supplementation intervention starting in first trimester of pregnancy in Bangladesh?
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“In addition to being sources of information, family members play a role in deciding whether or not a pregnant woman will take the supplements, as seen in others settings also [26,37].”
Background
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“In a study in Senegal, counselling by midwives to pregnant women regarding the transient nature of side-effects with Fe–folic acid supplements and specifically explaining to them that the tablets would improve health were also important determinants of compliance((33)).”
Background
Improving Adherence to Oral Iron Supplementation During Pregnancy
Bilimale, A. (2010) · australasian medical journal · doi:10.4066/amj.2010.291 · Cited by 50 · see citing works
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“Though HCPs have traditionally been the main source of health information for clients and patients [47], CHVs have emerged as an important source of health information as well [11, 14, 48].”
Background
Intermittent oral iron supplementation during pregnancy
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Programmatic Effects of a Large-Scale Multiple-Micronutrient Supplementation Trial in Indonesia: Using Community Facilitators as Intermediaries for Behavior Change
Shankar, A. V., Asrilla, Z., Kadha, J. K., Sebayang, S. K., Apriatni, M., Sulastri, A., Sunarsih, E., & Shankar, A. (2009) · Food and Nutrition Bulletin · doi:10.1177/15648265090302s204 · Cited by 49 · see citing works
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Result
Demand and supply factors of iron-folic acid supplementation and its association with anaemia in North Indian pregnant women
Varghese, J. S., Swaminathan, S., Kurpad, A. V., & Thomas, T. S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210634 · Cited by 57 · see citing works
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“These gastrointestinal side effects are well known to affect he general wellbeing of women and therefore represent the main reason for low compliance with oral iron therapy [6,10,42-46].”
Background
Iron Supplementation Affects Hematologic Biomarker Concentrations and Pregnancy Outcomes among Iron-Deficient Tanzanian Women.
Abioye, A., Aboud, S., Premji, Z., Etheredge, A. J., Gunaratna, N. S., Sudfeld, C., Mongi, R., Meloney, L. G., Darling, A., Noor, R., et al. (2016) · Journal of NutriLife · doi:10.3945/jn.115.225482 · Cited by 46 · see citing works
“3) Occupation Unemployed 288 (48) Unskilled 191 (32) Skilled informal 7 (1) Skilled formal 51 (9) Business/professional 61 (10) Meat consumption, g/wk ,75 129 (22) $75 462 (78) Number of household assets(2) 0–5 34 (6) 6–8 263 (44) 9–10 298 (50) Hemoglobinopathy Suggestive of thalassemia 48 (8) Not suggestive 552 (92)…”
Background
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Bottleneck analysis at district level to illustrate gaps within the district health system in Uganda
Henriksson, D. K., Fredriksson, M., Waiswa, P., Selling, K., & Peterson, S. S. (2017) · Global Health Action · doi:10.1080/16549716.2017.1327256 · Cited by 45 · see citing works
“Indonesia [42] and Senegal [43,44], and as this is a demand-side determinant, it calls for increased awareness among pregnant women as well as the community at large in order to support long-term use to improve women’s iron levels during pregnancy.”
Background
A rapid, simple questionnaire to assess gastrointestinal symptoms after oral ferrous sulphate supplementation
Pereira, D. I. A., Irving, S. C., Lomer, M. C. E., & Powell, J. J. (2014) · BMC Gastroenterology · doi:10.1186/1471-230x-14-103 · Cited by 61 · see citing works
“Gastrointestinal symptoms impact on the general wellbeing of individuals [30-37] and are known to affect compliance with oral iron therapy and, therefore, treatment efficacy [7,19,38-40].”
Background
Assessment of adherence to iron supplementation among pregnant women in the Yaounde gynaeco-obstetric and paediatric hospital
Fouelifack, F. Y., Sama, J., & Sone, C. (2019) · The Pan African Medical Journal · doi:10.11604/pamj.2019.34.211.16446 · Cited by 43 · see citing works
“According to studies in Saudi Arabia [18], Senegal [15] and India [19], side effect was reported as”
BackgroundInfluential
Multiple-micronutrient supplementation for women during pregnancy.
Haider, B., & Bhutta, Z. A. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004905.pub4 · Cited by 43 · see citing works
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Psychological and Social Factors Associated with Late Pregnancy Iron Deficiency Anaemia in Rural Viet Nam: A Population-Based Prospective Study
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“The important role of education about iron supplementation during antenatal consultations in maximizing compliance has been reported in other low- and lower-middle-income countries [38,39].”
Background
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Christides, T., Wray, D. S., McBride, R., Fairweather, R., & Sharp, P. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0815-8 · Cited by 38 · see citing works
“Current strategies for the treatment of IDA are based on oral ferrous iron supplements; however, these are poorly tolerated by patients due to a range of GI side-effects [6-9].”
Background
Trials of Improved Practices (TIPs) to Enhance the Dietary and Iron-Folate Intake during Pregnancy- A Quasi Experimental Study among Rural Pregnant Women of Varanasi, India
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Community-based distribution of iron–folic acid supplementation in low- and middle-income countries: a review of evidence and programme implications
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“on a daily basis was reported as a primary reason for noncompliance in settings such as India, Mali, Pakistan, the Philippines and Senegal((19,21,25,28)).”
BackgroundInfluential
Multiple Micronutrient Supplements Are More Cost-effective Than Iron and Folic Acid: Modeling Results from 3 High-Burden Asian Countries
Kashi, B., Godin, C., Kurzawa, Z., Verney, A., Busch‐Hallen, J., & De‐Regil, L. M. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz052 · Cited by 38 · see citing works
Adherence partners are an acceptable behaviour change strategy to support calcium and iron‐folic acid supplementation among pregnant women in Ethiopia and Kenya
Martin, S., Omotayo, M. O., Chapleau, G. M., Stoltzfus, R. J., Birhanu, Z., Ortolano, S. E., Pelto, G. H., & Dickin, K. L. (2016) · Maternal and Child Nutrition · doi:10.1111/mcn.12331 · Cited by 32 · see citing works
“…to supplements, they often experience inadequate counselling (Galloway et al. 2002) and more proximal barriers to adherence such as family disapproval (Aguayo et al. 2005; Taye et al. 2015) and forgetting (Gebremedhin et al. 2014; Kulkarni et al. 2010; Zavaleta et al. 2014; Seck and Jackson 2008).”
Background
A Qualitative Study of Factors Influencing Initiation and Adherence to Micronutrient Supplementation Among Women of Reproductive Age in Vietnam
Nechitilo, M., Nguyen, P. H., Girard, A. W., González-Casanova, I., Martorell, R., DiGirolamo, A. M., & Ramakrishnan, U. (2016) · Food and Nutrition Bulletin · doi:10.1177/0379572116647830 · Cited by 33 · see citing works
“Previous research on factors affecting prenatal iron supplementation have identified the barriers of negative side effects and forgetting as having a negative impact on adherence,(3,17-20) while others have found a positive association between high perceived health benefits of supplements and consistent adherence.(1,3…”
Background
Adherence to multiple micronutrient powder among young children in rural Bangladesh: a cross-sectional study
Angdembe, M. R., Choudhury, N., Haque, M. R., & Ahmed, T. (2015) · BMC Public Health · doi:10.1186/s12889-015-1752-z · Cited by 33 · see citing works
“Other studies have reported similar results where the advice of a health worker, in this case midwife positively affected adherence to iron supplementation among women of reproductive age [27] and among pregnant women [28].”
BackgroundResult
Process evaluation of a national school-based iron supplementation program for adolescent girls in Iran
Kheirouri, S., & Alizadeh, M. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-959 · Cited by 31 · see citing works
“A high rate of non-compliance has also been reported in similar intervention programs targeting pregnant women [17-20].”
Is it Time to Replace Iron Folate Supplements in Pregnancy with Multiple Micronutrients?
Bhutta, Z. A., Imdad, A., Ramakrishnan, U., & Martorell, R. (2012) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2012.01313.x · Cited by 33 · see citing works
Determinants of Iron Consumption among Pregnant Women in Southern Senegal
Niang, K., Faye, A., Diégane Tine, J. A., Diongue, F. B., Ndiaye, B., Ndiaye, M. B., Ndiaye, P., & Tal-Dia, A. (2017) · Open Journal of Obstetrics and Gynecology · doi:10.4236/ojog.2017.71005 · Cited by 32 · see citing works
“In Senegal, there are 392 deaths per 100,000 NV against 723 deaths per 100,000 NV in the region of Kolda where the health care situation is unsatisfactory [4].”
ResultInfluential
Individual and Structural Environmental Influences on Utilization of Iron and Folic Acid Supplementation among Pregnant Women in Harare, Zimbabwe
Tinago, C. B., Ingram, L., Blake, C., & Frongillo, E. (2016) · Maternal and Child Nutrition · doi:10.1111/mcn.12350 · Cited by 32 · see citing works
“…lack of knowledge, side effects and difficult access and underutilization of ANC services, while utilization was enhanced by improved health for mother and baby, less fatigue, and improved appetite (Galloway &McGuire 1994; Galloway et al. 2002; Seck & Jackson 2008; Nisar et al. 2014).”
Background
Patterns of compliance with prenatal iron supplementation among Peruvian women.
Zavaleta, N., Caulfield, L., Figueroa, A., & Chen, P. (2014) · Maternal and Child Nutrition · doi:10.1111/j.1740-8709.2012.00407.x · Cited by 31 · see citing works
“These included maternal age, education, income, marital status, caste, smoking and drinking (Ekstrom et al. 1996; Aguayo et al. 2005; Seck & Jackson 2007; Lutsey et al. 2008; Kulkarni et al. 2009).”
BackgroundResultInfluential
With adaptation, the WHO guidelines on calcium supplementation for prevention of pre‐eclampsia are adopted by pregnant women
Omotayo, M. O., Martin, S., Stoltzfus, R. J., Ortolano, S. E., Mwanga, E., & Dickin, K. L. (2017) · Maternal and Child Nutrition · doi:10.1111/mcn.12521 · Cited by 33 · see citing works
“…of micronutrient recommendations have focused on iron supplementation among end‐users in low‐income settings (Aguayo et al., 2005; Dairo & Lawoyin, 2006; Galloway et al., 2002; Galloway & McGuire, 1994; Seck & Jackson, 2008; Tessema, Jefferds, Cogswell, & Carlton, 2009; Young & Ali, 2005).”
Adherence-Specific Social Support Enhances Adherence to Calcium Supplementation Regimens among Pregnant Women
Martin, S., Omotayo, M. O., Pelto, G. H., Chapleau, G. M., Stoltzfus, R. J., & Dickin, K. L. (2017) · Journal of Nutrition · doi:10.3945/jn.116.242503 · Cited by 27 · see citing works
Reproductive morbidity among Iranian women; issues often inappropriately addressed in health seeking behaviors
Tehrani, F. R., Simbar, M., & Abedini, M. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-863 · Cited by 26 · see citing works
“Active screening of these women and referring of complicated cases could significantly reduce secondary complications such as anemia, a major indirect cause of maternal mortality [38] In the present study, the majority of women with reproductive morbidities had not sought appropriate care except for infertility; this…”
Background
Maternal knowledge on iron and folic acid supplementation and associated factors among pregnant women in a rural County in Kenya
Kamau, M., Mirie, W., & Kimani, S. (2019) · International Journal of Africa Nursing Sciences · doi:10.1016/j.ijans.2019.01.005 · Cited by 27 · see citing works
Compliance with the consumption of iron and folate supplements by pregnant women in Mafikeng local municipality, North West province, South Africa
Mbhenyane, X., & Cherane, M. (2017) · African Health Sciences · doi:10.4314/ahs.v17i3.8 · Cited by 25 · see citing works
Time to start and adherence to iron-folate supplement for pregnant women in antenatal care follow up; Northern Ethiopia
Gebremichael, T. G., Haftu, H., & Gereziher, T. A. (2019) · Patient Preference and Adherence · doi:10.2147/ppa.s184168 · Cited by 26 · see citing works
Antenatal care and mothers’ education improved iron-folic acid adherence at Denbiya district health centers, Northwest Ethiopia: using pills count method
Tarekegn, M., Wubshet, M., Atenafu, A., Derso, T., & Woretaw, A. (2019) · Archives of Public Health · doi:10.1186/s13690-019-0356-y · Cited by 24 · see citing works
Acceptability and Utilization of Three Nutritional Supplements during Pregnancy: Findings from a Longitudinal, Mixed-Methods Study in Niger
Clermont, A., Kodish, S. R., Seck, A. M., Salifou, A., Rosen, J. G., Grais, R. F., & Isanaka, S. (2018) · Nutrients · doi:10.3390/nu10081073 · Cited by 23 · see citing works
“A large number of individual and program-related factors have been identified as influencing adherence, including organoleptic properties of the supplements [13,16,20,22], provision of the supplement at no cost [14,21], reminders to take the supplement [15,16,21], and perceptions of supplement benefits [14,15,17,20].”
Background
The Experience of Anaemia and Ingesting Oral Iron Supplementation in Pregnancy: A Qualitative Study
O’Toole, F., Hokey, E., McAuliffe, F. M., & Walsh, J. (2024) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2024.03.005 · Cited by 14 · see citing works
Impact of Hypertensive Disorders of Pregnancy on Stillbirth and Other Perinatal Outcomes: A Multi-Center Retrospective Study
Basta, M., Hanif, K., Zafar, S., Khabazeh, A., Amin, F., Khan, S. S., Ghaffar, U., Muthanna, F. M. S., & Wali, S. (2022) · Cureus · doi:10.7759/cureus.22788 · Cited by 24 · see citing works
Treatment response to standard of care for severe anemia in pregnant women and effect of multivitamins and enhanced anthelminthics.
Christian, P., Shahid, F., Rizvi, A., Klemm, R., & Bhutta, Z. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26826 · Cited by 21 · see citing works
Barriers and facilitators of micronutrient supplementation among non-pregnant women of reproductive age in Johannesburg, South Africa
Silubonde, T. M., Draper, C. E., Baumgartner, J., Ware, L. J., Smuts, C. M., & Norris, S. A. (2022) · PLOS Global Public Health · doi:10.1371/journal.pgph.0001310 · Cited by 24 · see citing works
Adherence to Iron with Folic Acid Supplementation Among Pregnant Women Attending Antenatal Care in Public Health Centers in Simada District, Northwest Ethiopia: Using Health Belief Model Perspective
Mekonnen, A., Alemnew, W., Abebe, Z., & Demissie, G. D. (2021) · Patient Preference and Adherence · doi:10.2147/ppa.s299294 · Cited by 21 · see citing works
“This result is supported by other studies in Ethiopia(17,31,32) and West Africa, Senegal.(33) The possible justifications for these may be getting advice may increase the level of knowledge, attitude and practice toward IFAS adherence.”
Result
Adherence to recommendations on lipid‐based nutrient supplement and iron and folic acid tablet consumption among pregnant and lactating women participating in a community health programme in northwest Bangladesh
Harding, K. L., Matias, S. L., Mridha, M. K., Moniruzzaman, M., Vosti, S. A., Hussain, S., Dewey, K. G., & Stewart, C. P. (2016) · Maternal and Child Nutrition · doi:10.1111/mcn.12252 · Cited by 21 · see citing works
“…Seck & Jackson 2008; Shankar et al. 2009; Kulkarni et al. 2010; Mridha et al. 2012), perceived benefits of the supplement (Ghanekar et al. 2002; Seck & Jackson 2008; Tessema et al. 2009; Oriji et al. 2011; Zavaleta et al. 2012) and remembering to take supplements (Ghanekar et al. 2002; Seck &…”
BackgroundResultInfluential
Factors associated with socio‐demographic characteristics and antenatal care and iron supplement use in Ethiopia, Kenya, and Senegal
Verney, A., Reed, B. A., Lumumba, J. B., & Kung’u, J. K. (2018) · Maternal and Child Nutrition · doi:10.1111/mcn.12565 · Cited by 15 · see citing works
“…school longer or reach higher levels of education are better informed about health services available to them and are in a better position to make decisions about their own health (Houweling, Ronsmans, Campbell, & Kunst, 2007; Seck & Jackson, 2008; Simkhada, Teijlingen, Porter, & Simkhada, 2008).”
Background
Predictors of optimum antenatal iron-folate supplementation in a low resource rural set-up in Eastern Kenya
Juma, M., Oiye, S., & Konyole, S. O. (2015) · Journal of Public Health and Epidemiology · doi:10.5897/jphe2015.0770 · Cited by 19 · see citing works
“One of the pathways in which spouse influence can positively affect iron supplementation is through the spouses acting as active reminders (Seck and Jackson, 2008; Nisar et al., 2014), and it is thus evident that the spouses of the study mothers are not playing this role in a significant manner.”
Background
Perinatal outcomes of women with hypertensive disorders of pregnancy in Jimma Medical Center, southwest Ethiopia: Retrospective cohort study
Jaleta, D. D., Gebremedhin, T., & Gerbaba, M. J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256520 · Cited by 22 · see citing works
Compliance to Iron-Folic Acid Supplementation and Its Association with the Number of ANC Visits in Ethiopia: Systematic Review and Meta-Analysis
Workineh, Y., Kasa, A. S., Ayalew, E., & Temesgen, W. A. (2019) · Advances in Preventive Medicine · doi:10.1155/2019/3602585 · Cited by 18 · see citing works
PROTOCOL: Nutrition interventions and programs for reducing mortality and morbidity in pregnant and lactating women and women of reproductive age: a systematic review
Middleton, P., Crowther, C. A., Bubner, T., Flenady, V., Bhutta, Z. A., Trach, T. S., & Lassi, Z. S. (2012) · Campbell Systematic Reviews · doi:10.1002/cl2.84 · Cited by 4 · see citing works
Maternal Knowledge Associated with the Prevalence of Iron and Folic Acid Supplementation Among Pregnant Women in Muntinlupa, Philippines: A Cross-Sectional Study
Yamashita, T., Roces, R. E. D., Llave, C., Tuliao, M. T. R., Kamau, M. W., Yamada, C., Tanaka, Y., Shimazawa, K., Iwamoto, S., & Matsuo, H. (2021) · Patient Preference and Adherence · doi:10.2147/ppa.s291939 · Cited by 17 · see citing works
Home consumption of two fortified balanced energy protein supplements by pregnant women in Burkina Faso
de Kok, B., Moore, K., Jones, L., Vanslambrouck, K., Toe, L. C., Ouédraogo, M., Ganaba, R., de Pee, S., Bedford, J., Lachat, C., et al. (2021) · Maternal and Child Nutrition · doi:10.1111/mcn.13134 · Cited by 17 · see citing works
“Overall, the need for clear instructions and educational message is often mentioned as a key element to ensure appropriate utilization (Aguayo et al., 2005; Kodish, Aburto, Hambayi, Kennedy, & Gittelsohn, 2015; Seck & Jackson, 2008).”
Background
Utilization and compliance with iron supplementation and predictors among pregnant women in Southeast Ethiopia
Beressa, G., Lencha, B., Bosha, T., & Egata, G. (2022) · Scientific Reports · doi:10.1038/s41598-022-20614-9 · Cited by 20 · see citing works
“94 Gestational age ≤ 12 3 (75) 1 (25) 1 1 13–24 92 (92) 8 (8) 3.”
Sorption behavior and release kinetics of iron (II) ions by oleoyl chitosan polymeric nanoparticles
Jaber, N., & Aiedeh, K. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.101354 · Cited by 16 · see citing works
An approach to Hemequity: Identifying the barriers and facilitators of iron deficiency reduction strategies in low‐ to middle‐income countries
Ge, S., Ali, S. H., Haldane, V. E., Bekdache, C., Tang, G. H., & Sholzberg, M. (2025) · British Journal of Haematology · doi:10.1111/bjh.19984 · Cited by 17 · see citing works
“43,51,53,56 62”
Factors associated with non-adherence to prescribed iron supplement use: a study with pregnant women in the city of Rio de Janeiro
Niquini, R. P., Bittencourt, S. D. D. A., Lacerda, E. M. D. A., Saunders, C., & Leal, M. D. C. (2016) · Revista Brasileira de Saúde Materno Infantil · doi:10.1590/1806-93042016000200007 · Cited by 14 · see citing works
Non-invasive hemoglobin screening device: a promising digital method for reducing anemia prevalence through routine screening and timely intervention
Mahapatra, P. P. D., Roy, C., Agarwal, K., Sharma, S. D., Chowdhury, S. R., Sharma, S., Rajagopal, H., & Meher, D. (2024) · Hematology · doi:10.1080/16078454.2024.2365078 · Cited by 9 · see citing works
“Also, another study found that the tablet’s unappealing taste, smell, or color, nausea, difficulty in swallowing and form of injection/liquid were some of the major deciding factors for women to discontinue taking iron supplements [33–37].”
Compliance with and acceptability of two fortified balanced energy protein supplements among pregnant women in rural Nepal
Lama, T., Moore, K., Isanaka, S., Jones, L., Bedford, J., de Pee, S., Katz, J., Khatry, S., Leclerq, S., & Tielsch, J. (2021) · Maternal and Child Nutrition · doi:10.1111/mcn.13306 · Cited by 13
Predictors of iron consumption for at least 90 days during pregnancy: Findings from National Demographic Health Survey, Pakistan (2017–2018)
Ali, S. A., Ali, S. A., Razzaq, S., Khowaja, N., Gutkind, S., Raheman, F. U., & Suhail, N. (2021) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-021-03825-2 · Cited by 11 · see citing works
“Likewise, 44% of preterm births, 25% of babies with low birth weight, and 21% of perinatal mortality are due to anemia during pregnancy in LMICs [10].”
ResultInfluential
Dietary diversity cutoff values predicting anemia varied between mid and term of pregnancy: a prospective cohort study
Zerfu, T., Baye, K., & Faber, M. (2019) · Journal of Health, Population and Nutrition · doi:10.1186/s41043-019-0196-y · Cited by 13 · see citing works
Routine Iron Supplementation and Anaemia by Third Trimester in a Nigerian Hospital
Adanikin, A. I., Awoleke, J., Olofinbiyi, B., Adanikin, P., & Ogundare, O. R. (2015) · Ethiopian Journal of Health Sciences · doi:10.4314/ejhs.v25i4.3 · Cited by 15 · see citing works
“Our compliance rate, however, is comparable with studies from India and Senegal where compliance was 65% and 69% respectively (23,24).”
Result
Compliance and patterns of iron-folic acid intake among adolescent girls and antenatal women in rural Tamil Nadu
Selvaraj, K., Arumugasamy, P., & Sarkar, S. (2017) · CHRISMED Journal of Health and Research · doi:10.4103/cjhr.cjhr_88_16 · Cited by 12 · see citing works
“[15,16] Compared to Indian settings studies reported from Africa had shown poor compliance among pregnant women.[22,23] A study conducted among adolescent tribal girls of Madhya Pradesh had shown 89% compliance, but this was an interventional study conducted under trial design.”
Result
Iron deficiency anemia status in Iranian pregnant women and children: an umbrella systematic review and meta-analysis
Dehghani, A., Molani-Gol, R., Rafraf, M., Mohammadi‐Nasrabadi, F., & Khodayari-zarnaq, R. (2024) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-024-06575-z · Cited by 12 · see citing works
“Adherence to supplements is very different and influenced by demographic, social and health factors [83–88] and this reason can cause differences in different regions of Iran.”
Background
Predictors of prenatal iron folic acid supplement utilization in Wolaita, South Ethiopia: a community based cross-sectional study (quantitative and qualitative approach)
Wana, E. W. (2020) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-020-02883-2 · Cited by 12 · see citing works
Using formative research to promote antenatal care attendance and iron folic acid supplementation in Zinder, Niger
Hess, S., Ouédraogo, C., Bamba, I., Wessells, K., Keith, N., Faye, T., Ndiaye, B., Doudou, M., & Nielsen, J. (2018) · Maternal and Child Nutrition · doi:10.1111/mcn.12525 · Cited by 12 · see citing works
Better-Educated, Older, or Unmarried Pregnant Women Comply Less with Iron–Folic Acid Supplementation in Southern Ethiopia
Seifu, C., Whiting, S., & Hailemariam, T. (2020) · Journal of Dietary Supplements · doi:10.1080/19390211.2019.1629145 · Cited by 11 · see citing works
“As reported by different studies (Seck and Jackson 2008; Gebremedhin et al. 2014), our findings also show that side effects impede compliance of IFA supplementation; similar results were observed in India (Bilimale et al. 2010) and the Philippines (Aikawa et al. 2006; Lutsey et al. 2008).”
Result
Prenatal anemia control and anemia in children aged 6–23 months in sub‐Saharan Africa
Wilunda, C., Tanaka, S., Esamai, F., & Kawakami, K. (2017) · Maternal and Child Nutrition · doi:10.1111/mcn.12375 · Cited by 10 · see citing works
“There is also need to improve compliance with iron supplementation as this may be a problem (Gebremedhin et al., 2014; Seck and Jackson, 2008), and to promote initiation of iron supplementation as early as possible during pregnancy to maximize the chance of taking the supplements for at least 6 months.”
Background
Survey of women's perceptions of information provided in the prevention or treatment of iron deficiency anaemia in an Australian tertiary obstetric hospital.
Vosnacos, E., & Pinchon, D. (2015) · Women and Birth · doi:10.1016/j.wombi.2014.11.004 · Cited by 9 · see citing works
ADHERENCE IN PREGNANCY: A SYSTEMATIC REVIEW OF THE LITERATURE
Oladejo, M., & Bewley, S. (2012) · Fetal and Maternal Medicine Review · doi:10.1017/s0965539512000113 · Cited by 10 · see citing works
Family-centered Health Education Intervention for Improving Iron−folic Acid Adherence and Anemia Reduction among Antenatal Mothers in Rural Jodhpur: A Quasi-experimental Study
Singh, G. P., Ranjitha, R., Baskaran, P., Goel, A. D., Gupta, M. K., Dileepan, S., Choudhary, Y., Rehana, V. R., & Raghav, P. R. (2024) · Indian Journal of Public Health · doi:10.4103/ijph.ijph_844_23 · Cited by 7 · see citing works
Prevalence and factors associated with compliance to iron and folic acid supplementation in pregnancy in Tamale Metropolis, Ghana
Wemakor, A., Garti, H., Akai, M. M., Napari, A. A., & Dankyi-Frimpomaa, J. (2020) · Nutrire · doi:10.1186/s41110-020-00120-6 · Cited by 8 · see citing works
“I have remained strong because of that food”: Acceptability and use of lipid-based nutrient supplements among pregnant HIV-infected Ugandan women receiving combination antiretroviral therapy
Young, S., Natamba, B., Luwedde, F., Nyafwono, D., Okia, B., Osterbauer, B., Natureeba, P., Johnson, L. M., Michel, C., Zheng, A., et al. (2015) · Aids and Behavior · doi:10.1007/s10461-014-0947-0 · Cited by 8 · see citing works
Adherence to iron folic acid supplementation and associated factors among antenatal CARE attending women in Sire district primary health care units, South-East Ethiopia: A facility based cross-sectional study
Berarti, A. E., Bore, M. G., & Beyene, B. (2023) · International Journal of Africa Nursing Sciences · doi:10.1016/j.ijans.2023.100526 · Cited by 5 · see citing works

Authors: Seck, B. C., & Jackson, R. T.
Affiliations: University of Maryland, College Park (US)
Corresponding author: Seck, Binetou C
Venue: Public Health Nutrition
Publisher: Cambridge University Press (CUP)
Published: 2008-06
Volume: 11
Issue: 6
Pages: 596-605
ISSN: 1368-9800 (ISSN-L)
1475-2727
DOI: 10.1017/s1368980007000924
OpenAlex: W2035452438
Cited by: 154
References: 0
Citations by year: 2026: 4 · 2025: 1 · 2024: 12 · 2023: 2 · 2022: 13 · 2021: 9 · 2020: 5 · 2019: 20 · 2018: 8 · 2017: 14 · 2016: 11 · 2015: 13 · 2014: 14 · 2013: 5 · 2012: 12
FWCI: 2.12
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Public Health Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Global Maternal and Child Health
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Public Health and Nutrition
Keywords: iron supplementation, folic acid, medication adherence, pregnant women, prenatal care, free medication, pill count, adverse effects, health education, midwife counseling, Senegal
MeSH terms: Adult, Female, Folic Acid, Folic Acid Deficiency, Humans, Patient Acceptance of Health Care, Patient Compliance, Patient Education as Topic, Pregnancy, Prenatal Care, Surveys and Questionnaires, Senegal, Anemia, Iron-Deficiency, Iron, Dietary, Dietary Supplements, Maternal Nutritional Physiological Phenomena

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Determinants of compliance with iron supplementation among pregnant women in Senegal

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