The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test
Open accessAbstract
The mechanism by which lithium exerts either its anti-manic or antidepressant effects remains to be fully elucidated. Although lithium inhibits the enzyme glycogen synthase kinase-3 (GSK-3) at concentrations that are relevant for treatment of bipolar disorder, it is unclear whether GSK-3-related mechanisms are responsible for its therapeutic effects in the treatment of this disease. We report that AR-A014418 (a selective GSK-3 inhibitor) induces behavioural changes that are consistent with the effects of antidepressant medications. Subacute intraperitoneal injections of AR-A014418 reduced immobility time in rats exposed to the forced swim test, a well-established model for antidepressant efficacy. In addition, the specificity of this effect is supported by our finding that AR-A014418 decreased spontaneous as well as amphetamine-induced activity. Taken together, these data support the hypothesis that lithium may exert its antidepressant effects through inhibition of GSK-3, and that novel small-molecule GSK-3 inhibitors may be useful for the treatment of bipolar disorder and depression.
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Cites
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GSK3 takes centre stage more than 20 years after its discovery
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Self-citationKaidanovich-Beilin, O., Milman, A., Weizman, A., Pick, C. G., & Eldar-Finkelman, H. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.01.008 · Cited by 276
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Self-citationGlycogen Synthase Kinase 3: A Target for Novel Mood Disorder Treatments
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Self-citationA molecular mechanism for the effect of lithium on development
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Self-citationAnimal Models of Bipolar Disorder: From a Single Episode to Progressive Cycling Models
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Cited by
The physiology, signaling, and pharmacology of dopamine receptors
Beaulieu, J.-M., & Gainetdinov, R. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.002642 · Cited by 2,763
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Akt/GSK3 Signaling in the Action of Psychotropic Drugs
Beaulieu, J.-M., Gainetdinov, R. R., & Caron, M. G. (2009) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.011008.145634 · Cited by 522
Dopamine receptors –IUPHAR R eview 13
Beaulieu, J., Espinoza, S., & Gainetdinov, R. R. (2015) · British Journal of Pharmacology · doi:10.1111/bph.12906 · Cited by 521
Therapeutic potential of mood stabilizers lithium and valproic acid:Beyond bipolar disorder
Chiu, C.-T., Wang, Z., Hunsberger, J. G., & Chuang, D.-M. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005512 · Cited by 404
Metadata
- Authors
- Gould, T. D., Einat, H., Bhat, R., & Manji, H. K.
- Venue
- The International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-12
- Volume
- 7
- Issue
- 4
- Pages
- 387-390
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W1998772348
- Cited by
- 314
- References
- 10
- FWCI
- 10.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gould, T. D., Einat, H., Bhat, R., & Manji, H. K. (2004). AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. The International Journal of Neuropsychopharmacology. https://doi.org/10.1017/s1461145704004535
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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