The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
Akt/GSK3 Signaling in the Action of Psychotropic Drugs
Abstract
Psychotropic drugs acting on monoamine neurotransmission are major pharmacological treatments for neuropsychiatric conditions such as schizophrenia, depression, bipolar disorder, Tourette syndrome, ADHD, and Alzheimer disease. Independent lines of research involving biochemical and behavioral approaches in normal and/or genetically modified mice provide converging evidence for an involvement of the signaling molecules Akt and glycogen synthase kinase-3 (GSK3) in the regulation of behavior by dopamine and serotonin (5-HT). These signaling molecules have also received attention for their role in the actions of psychoactive drugs such as antidepressants, antipsychotics, lithium, and other mood stabilizers. Furthermore, investigations of the mechanism by which D2 dopamine receptors regulate Akt/GSK3 signaling strongly support the physiological relevance of a new modality of G protein–coupled receptor (GPCR) signaling involving the multifunctional scaffolding protein beta-arrestin 2. Elucidation of the contribution of multiple signaling pathways to the action of psychotropic drugs may provide a better biological understanding of psychiatric disorders and lead to more efficient therapeutics.
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Cites
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The physiology, signaling, and pharmacology of dopamine receptors
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Dopamine: Functions, Signaling, and Association with Neurological Diseases
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Trace Amines and Their Receptors
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Metadata
- Authors
- Beaulieu, J.-M., Gainetdinov, R. R., & Caron, M. G.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2009-02-01
- Volume
- 49
- Issue
- 1
- Pages
- 327-347
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2158321076
- Cited by
- 522
- References
- 142
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Beaulieu, J.-M., Gainetdinov, R. R., & Caron, M. G. (2009). Akt/GSK3 Signaling in the Action of Psychotropic Drugs. Annual Review of Pharmacology and Toxicology. https://doi.org/10.1146/annurev.pharmtox.011008.145634
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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