β2 Nicotinic acetylcholine receptor availability in post-traumatic stress disorder
Abstract
Availability of nicotinic acetylcholine receptors containing beta2 subunits (beta2-nAChRs) was studied in unmedicated, symptomatic patients with post-traumatic stress disorder (PTSD) and healthy control subjects, all current non-smokers. A subgroup of participants had a history of smoking. Availability of beta2-nAChRs in the mesiotemporal cortex, prefrontal cortex, thalamus and striatum was determined using the radiotracer [123I]5-IA-85380 ([123I]5-IA) and single-photon emission computed tomography (SPECT). PTSD symptoms were assessed using the Clinician-Administered PTSD Scale (CAPS). Never-smoking PTSD patients compared to never-smoking healthy controls showed significantly higher [123I]5-IA binding in the mesiotemporal cortex (ANOVA: F=6.21, d.f.=1, 11, p=0.030). Among all PTSD patients, there was a significant correlation between the re-experiencing symptom cluster and thalamic [123I]5-IA binding (R2=0.66, p=0.019, Bonferroni corrected). These findings not only suggest an involvement of beta2-nAChRs in the pathophysiology of PTSD but also raise the possibility that this receptor may be a novel molecular target for drug development.
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PTSD patients who never smoked showed significantly higher β2 nAChR density in the mesiotemporal cortex including the amygdala and hippocampus compared to healthy individuals who never smoked.
“Czermak et al. (2008) found that PTSD patients who never smoked showed significantly higher β2 nAChR density in the mesiotemporal cortex including the amygdala and hippocampus compared to healthy individuals who never smoked.”
From Nicotine addiction and psychiatric disorders (2015) · cites this paper as Czermak et al. (2008)
The effects of nicotine on hippocampus-dependent fear memories require activation and upregulation of high-affinity β2-containing nAChRs.
“results from the studies using acute, chronic, and withdrawal from chronic nicotine suggest that the effects of nicotine on hippocampus-dependent fear memories require the activation and upregulation of the high-affinity β2-containing nAChRs.”
From Nicotine addiction and psychiatric disorders (2015) · cites this paper as Czermak et al., 2008
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- Authors
- Czermak, C., Staley, J. K., Kasserman, S., Bois, F., Young, T., Henry, S., Tamagnan, G. D., Seibyl, J. P., Krystal, J. H., & Neumeister, A.
- Affiliations
- Yale University (US)
- Institute for Neurodegenerative Disorders (US)
- Corresponding author
- Neumeister, Alexander
- Venue
- The International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-01-11
- Volume
- 11
- Issue
- 03
- Pages
- 419-24
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W2166846775
- Cited by
- 31
- References
- 29
- Citations by year
- 2026: 1 · 2023: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 1
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- Eli Lilly and Company
- Max Kade Foundation
- National Research Foundation
- National Institutes of Health (5k05aa014906-03)
- Pfizer Pharmaceuticals
- National Institute on Alcohol Abuse and Alcoholism (K05 AA 14906-01)
- National Institute on Drug Abuse (R01DA015577)
- UCB Pharma
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- post-traumatic stress disorder, receptor availability, thalamus, re-experiencing symptoms, smoking history, PTSD pathophysiology
- MeSH terms
- Adult, Analysis of Variance, Azetidines, Brain, Female, Humans, Iodine Radioisotopes, Magnetic Resonance Imaging, Male, Middle Aged, Pyridines, Receptors, Nicotinic, Stress Disorders, Post-Traumatic, Trauma Severity Indices, Tomography, Emission-Computed, Single-Photon
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