Prefrontal cortex glutathione S-transferase levels in patients with bipolar disorder, major depression and schizophrenia
Open accessAbstract
Antioxidant defence systems have received increasing attention in the pathophysiology of psychiatric disorders, including: bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SCZ). Recently, we reported decreased glutathione (GSH) levels in post-mortem prefrontal cortex from patients with BD, MDD, and SCZ. To explore this further, we evaluated the levels of two glutathione S-transferase (GST) isoforms via immunoblotting: GST Pi and GST Mu. GST Pi levels were not affected in any of the patients groups vs. controls. GST Mu levels were significantly decreased in patients with MDD and SCZ but not BD. Compared to controls, GST Mu levels were not different in BD patients who had been treated with mood stabilizers at the time of death but were significantly lower in those not taking mood stabilizers at the time of death. These data suggest that GST Mu may be a target for mood stabilizers.
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Reduced oxidized and total GSH are found in the prefrontal cortex of MDD subjects as compared to controls.
“Two recent studies showed reduced oxidized and total GSH in the prefrontal cortex of MDD subjects as compared to controls [31, 36].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [36]
GST levels are reduced in MDD patients and no effects of antidepressant treatment were observed.
“In a subsequent study with the same cohort, GST levels were also reduced in MDD patients and no effects of antidepressant treatment were observed [36].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [36]
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- Authors
- Gawryluk, J. W., Wang, J.-F., Andreazza, A. C., Shao, L., Yatham, L. N., & Young, L. T.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Young, L. Trevor
- Venue
- The International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-05-09
- Volume
- 14
- Issue
- 08
- Pages
- 1069-1074
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W2313660162
- Cited by
- 99
- References
- 27
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 9 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 7 · 2014: 10 · 2013: 11 · 2012: 9
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Sanofi
- Stanley Medical Research Institute
- National Alliance for Research on Schizophrenia and Depression
- Canadian Psychiatric Research Foundation
- Michael Smith Health Research BC
- Servier
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- glutathione S-transferase, GST mu, glutathione S-transferase pi, prefrontal cortex, bipolar disorder, major depressive disorder, schizophrenia, antioxidant defense, mood stabilizers, postmortem brain, glutathione
- MeSH terms
- Adult, Bipolar Disorder, Brain, Major Depressive Disorder, Depressive Disorder, Major, Female, Glutathione Transferase, Humans, Male, Middle Aged, Schizophrenia, Prefrontal Cortex, Control Groups
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