The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Lithium neuroprotection: molecular mechanisms and clinical implications
Abstract
Lithium has emerged as a neuroprotective agent efficacious in preventing apoptosis-dependent cellular death. Lithium neuroprotection is provided through multiple, intersecting mechanisms, although how lithium interacts with these mechanisms is still under investigation. Lithium increases cell survival by inducing brain-derived neurotrophic factor and thereby stimulating activity in anti-apoptotic pathways, including the phosphatidylinositol 3-kinase/Akt and the mitogen-activated protein kinase pathways. In addition, lithium reduces pro-apoptotic function by directly and indirectly inhibiting glycogen synthase kinase-3β activity and indirectly inhibiting N-methyl-D-aspartate (NMDA)-receptor-mediated calcium influx. Lithium-induced regulation of anti- and pro-apoptotic pathways alters a wide variety of downstream effectors, including β-catenin, heat shock factor 1, activator protein 1, cAMP-response-element-binding protein, and the Bcl-2 protein family. Lithium neuroprotection has a wide variety of clinical implications. Beyond its present use in bipolar mood disorder, lithium's neuroprotective abilities imply that it could be used to treat or prevent brain damage following traumatic injury, such as stroke, and neurodegenerative diseases such as Huntington's and Alzheimer's diseases.
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Cites
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Regulation of Mammalian Autophagy in Physiology and Pathophysiology
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Allostatic load in bipolar disorder: Implications for pathophysiology and treatment
Kapczinski, F., Vieta, E., Andreazza, A. C., Frey, B. N., Gomes, F. A., Tramontina, J., Kauer-Sant’Anna, M., Grassi-Oliveira, R., & Post, R. M. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.10.005 · Cited by 480
Therapeutic potential of mood stabilizers lithium and valproic acid:Beyond bipolar disorder
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Metadata
- Authors
- Rowe, M. K., & Chuang, D.-M.
- Venue
- Expert Reviews in Molecular Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2004-10-08
- Volume
- 6
- Issue
- 21
- Pages
- 1-18
- ISSN
- 1462-3994 (ISSN-L)
- OpenAlex
- W1979533444
- Cited by
- 197
- References
- 11
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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