The DOI matches its Crossref record; 190 of the 190 references it cites were found in a registry or an index.
Emerging role of the cannabinoid receptor CB 2 in immune regulation: therapeutic prospects for neuroinflammation
Open accessAbstract
There is now a large body of data indicating that the cannabinoid receptor type 2 (CB 2 ) is linked to a variety of immune events. This functional relevance appears to be most salient in the course of inflammation, a process during which there is an increased number of receptors that are available for activation. Studies aimed at elucidating signal transduction events resulting from CB 2 interaction with its native ligands, and of the role of exogenous cannabinoids in modulating this process, are providing novel insights into the role of CB 2 in maintaining a homeostatic immune balance within the host. Furthermore, these studies suggest that the CB 2 may serve as a selective molecular target for therapeutic manipulation of untoward immune responses, including those associated with a variety of neuropathies that exhibit a hyperinflammatory component.
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“Endocannabinoids mediate inflammation by regulating cytokines at different steps throughout the inflammatory response (Cabral and Griffin-Thomas, 2009).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Cabral and Griffin-Thomas, 2009
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“For example, THC and AEA suppress proinflammatory cytokines and enhance anti-inflammatory cytokines in both innate and adaptive immune responses (Cabral and Griffin-Thomas, 2009).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Cabral and Griffin-Thomas, 2009
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“Cannabinoids also inhibit the cell-specific proliferation of B and T cells (Cabral and Griffin-Thomas, 2009;Klein and Cabral, 2006).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Cabral and Griffin-Thomas, 2009
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Cites
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Research works printed but not linked: 4
- http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=105400 (amyotrophic lateral sclerosis)
- http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=114610 (CB1)
- http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605051 (CB2) The National Institute of Drug Abuse website includes listings of clinical trials:
- http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=126200 (multiple sclerosis)
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CB2: a cannabinoid receptor with an identity crisis
Atwood, B. K., & Mackie, K. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00729.x · Cited by 659
“Indeed, CB2 activation affects a myriad of immune responses from inflammation to neuroprotection (Cabral and Griffin-Thomas, 2009).”
BackgroundThe serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors
Marrs, W., Blankman, J. L., Horne, E. A., Thomazeau, A., Lin, Y. H., Coy, J. W., Bodor, Á. L., Muccioli, G. G., Hu, S. S., Woodruff, G., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2601 · Cited by 460
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Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs
Gamble, L.-J., Boesch, J. M., Frye, C. W., Schwark, W. S., Mann, S., Wolfe, L. M., Brown, H., Berthelsen, E. S., & Wakshlag, J. J. (2018) · Frontiers in Veterinary Science · doi:10.3389/fvets.2018.00165 · Cited by 354
Metadata
- Authors
- Cabral, G. A., & Griffin-Thomas, L.
- Affiliations
- Virginia Commonwealth University (US)
- Corresponding author
- Cabral, Guy A.
- Venue
- Expert Reviews in Molecular Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-01
- Volume
- 11
- Pages
- e3-e3
- ISSN
- 1462-3994 (ISSN-L)
- PMC
- PMC2768535
- OpenAlex
- W2023366312
- Cited by
- 408
- References
- 190
- Citations by year
- 2026: 25 · 2025: 37 · 2024: 22 · 2023: 24 · 2022: 23 · 2021: 29 · 2020: 34 · 2019: 24 · 2018: 28 · 2017: 37 · 2016: 13 · 2015: 15 · 2014: 22 · 2013: 22 · 2012: 17
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Expert Reviews in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Cambridge
- National Institutes of Health
- National Institute on Drug Abuse (DA005832, R01DA005832, R01DA029532)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- CB2 receptor, immune regulation, neuroinflammation, signal transduction, exogenous cannabinoids, immune homeostasis, neuropathy, hyperinflammation, therapeutic target
- MeSH terms
- Amino Acid Sequence, Animals, Humans, Inflammation, Molecular Sequence Data, Nervous System, Research, Neuroimmunomodulation, Receptor, Cannabinoid, CB2
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