The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Collisional Activation of Large Multiply Charged Ions Using Fourier Transform Mass Spectrometry
Abstract
For small singly charged ions, Fourier transform mass spectrometry (FTMS) has demonstrated the ability to perform multistage mass spectral experiments (MSn) with high resolution and high mass accuracy using collisionally activated dissociation (CAD). The combination of electrospray ionization (ESI) with the FTMS provides the potential to extend these capabilities for structural characterization of large biomolecules. The standard FTMS-CAD method is problematic in that it is inefficient and produces ions well away from the center of the cell. More efficient collisional methods have been demonstrated for small molecules (sustained off-resonance irradiation (SORI) CAD, very low energy (VLE) CAD, multiple excitation collisional activation (MECA)) that provide the additional benefit of producing product ions closer to the center of the trapped ion cell. The efficiency (> 92%) for producing sequence-informative peaks from large multiply charged ions is far better than standard CAD. Disadvantages, such as blind spots where no product ions are observed, and isotopic distortions which can cause an incorrect mass assignment, must be considered when methods designed for small singly charged ions are applied to large multiply charged ions. SORI provided the highest efficiency, selectivity, and resolving power (9 x 10(5)) for product ion spectra and is recommended for most applications because of its ease of implementation.
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Cites
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Cited by
Senko, M. W., Hendrickson, C. L., Emmett, M. R., Shi, S. D. H., & Marshall, A. G. (1997) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(97)00126-8 · Cited by 462
Self-citationGe, Y., Rybakova, I. N., Xu, Q., & Moss, R. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813369106 · Cited by 154
Proteomics in heart failure: top-down or bottom-up?
Gregorich, Z. R., Chang, Y.-H., & Ge, Y. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1471-9 · Cited by 69
Patrie, S. M., Ferguson, J. T., Robinson, D. E., Whipple, D., Rother, M., Metcalf, W. W., & Kelleher, N. L. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500219-mcp200 · Cited by 62
In-depth proteomic analysis of human tropomyosin by top-down mass spectrometry
Peng, Y., Yu, D., Gregorich, Z., Chen, X., Beyer, A. M., Gutterman, D. D., & Ge, Y. (2013) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-013-9352-y · Cited by 42
Metadata
- Authors
- Senko, M. W., Speir, J. P., & McLafferty, F. W.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1994-09-15
- Volume
- 66
- Issue
- 18
- Pages
- 2801-2808
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2085145164
- Cited by
- 263
- References
- 25
- FWCI
- 9.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Senko, M. W., Speir, J. P., & McLafferty, F. W. (1994). Collisional Activation of Large Multiply Charged Ions Using Fourier Transform Mass Spectrometry. Analytical Chemistry. https://doi.org/10.1021/ac00090a003
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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