The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
External accumulation of ions for enhanced electrospray ionization fourier transform ion cyclotron resonance mass spectrometry
Abstract
Electrospray ionization (ESI) in combination with Fourier transform ion cyclotron resonance (FTICR) mass spectrometry provides for mass analysis of biological molecules with unrivaled mass accuracy, resolving power and sensitivity. However, ESI FTICR MS performance with on-line separation techniques such as liquid chromatography (LC) and capillary electrophoresis has to date been limited primarily by pulsed gas assisted accumulation and the incompatibility of the associated pump-down time with the frequent ion beam sampling requirement of on-line chromatographic separation. Here we describe numerous analytical advantages that accrue by trapping ions at high pressure in the first rf-only octupole of a dual octupole ion injection system before ion transfer to the ion trap in the center of the magnet for high performance mass analysis at low pressure. The new configuration improves the duty cycle for analysis of continuously generated ions, and is thus ideally suited for on-line chromatographic applications. LC/ESI FTICR MS is demonstrated on a mixture of 500 fmol of each of three peptides. Additional improvements include a fivefold increase in signal-to-noise ratio and resolving power compared to prior methods on our instrument.
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Cites
Electrospray ionization–principles and practice
Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1990) · Mass Spectrometry Reviews · doi:10.1002/mas.1280090103 · Cited by 1,569
Tailored excitation for Fourier transform ion cyclotron mass spectrometry
Marshall, A. G., Wang, T. C. L., & Ricca, T. L. (1985) · Journal of the American Chemical Society · doi:10.1021/ja00312a015 · Cited by 631
Self-citationSmith, R. D., Loo, J. A., Loo, R. R. O., Busman, M., & Udseth, H. R. (1991) · Mass Spectrometry Reviews · doi:10.1002/mas.1280100504 · Cited by 569
Micro-electrospray mass spectrometry: Ultra-high-sensitivity analysis of peptides and proteins
Emmett, M. R., & Caprioli, R. M. (1994) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(94)85001-1 · Cited by 510
Self-citationCovey, T. R., Huang, E. C., & Henion, J. D. (1991) · Analytical Chemistry · doi:10.1021/ac00013a003 · Cited by 446
Attomole Protein Characterization by Capillary Electrophoresis-Mass Spectrometry
Valaskovic, G. A., Kelleher, N. L., & McLafferty, F. W. (1996) · Science · doi:10.1126/science.273.5279.1199 · Cited by 398
An electrospray‐ionization mass spectrometer with new features
Chowdhury, S. K., Katta, V., & Chait, B. T. (1990) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1290040305 · Cited by 323
High-resolution electrospray mass spectra of large molecules
Henry, K. D., Quinn, J. P., & McLafferty, F. (1991) · Journal of the American Chemical Society · doi:10.1021/ja00014a043 · Cited by 309
Collisional Activation of Large Multiply Charged Ions Using Fourier Transform Mass Spectrometry
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Self-citationFourier-transform mass spectrometry of large molecules by electrospray ionization.
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Cited by
Proteomics by Mass Spectrometry: Approaches, Advances, and Applications
Yates, J. R., Ruse, C. I., & Nakorchevsky, A. (2009) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-061008-124934 · Cited by 1,078
High-Resolution Native Mass Spectrometry
Tamara, S., den Boer, M. A., & Heck, A. J. R. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00212 · Cited by 511
Top Down proteomics: Facts and perspectives
Catherman, A. D., Skinner, O. S., & Kelleher, N. L. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.02.041 · Cited by 507
“Significant advances to FT-ICR technology, often focused on improving the analysis of intact proteins, included increases in magnetic field [88,89], addition of a resolving quadrupole for mass selection [90], and an accumulation octupole for ion storage before transmission to the ICR cell [91,92].”
Hendrickson, C. L., Quinn, J. P., Kaiser, N. K., Smith, D. F., Blakney, G. T., Chen, T., Marshall, A. G., Weisbrod, C. R., & Beu, S. C. (2015) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-015-1182-2 · Cited by 278
Self-citationHigh Resolution Mass Spectrometry
Xian, F., Hendrickson, C. L., & Marshall, A. G. (2012) · Analytical Chemistry · doi:10.1021/ac203191t · Cited by 281
Self-citation
Metadata
- Authors
- Senko, M. W., Hendrickson, C. L., Emmett, M. R., Shi, S. D. H., & Marshall, A. G.
- Venue
- Journal of the American Society for Mass Spectrometry
- Publisher
- American Chemical Society (ACS)
- Published
- 1997-09-01
- Volume
- 8
- Issue
- 9
- Pages
- 970-976
- ISSN
- 1044-0305 (ISSN-L)
- OpenAlex
- W1981001077
- Cited by
- 462
- References
- 30
- FWCI
- 15.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Senko, M. W., Hendrickson, C. L., Emmett, M. R., Shi, S. D. H., & Marshall, A. G. (1997). External accumulation of ions for enhanced electrospray ionization fourier transform ion cyclotron resonance mass spectrometry. Journal of the American Society for Mass Spectrometry. https://doi.org/10.1016/s1044-0305(97)00126-8
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