The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Primary Sequence Information from Intact Proteins by Electrospray Ionization Tandem Mass Spectrometry
Abstract
Tandem mass spectrometry has been used to obtain information related to portions of the primary sequence for an intact protein, bovine ribonuclease A. Multiply charged molecular ions, generated by electrospray ionization, were collisionally dissociated at low energies in a triple quadrupole mass spectrometer to yield singly and multiply charged fragment ions that can be assigned to the known sequence of the protein. Dissociation of the highly charged molecular ions resulted in pairs of complementary product ions. The higher order (gas-phase) protein structure affects the dissociation processes, as observed in comparisons of tandem mass spectra of the native and disulfide-reduced forms of ribonuclease A.
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Citations
Cites
Electrospray Ionization for Mass Spectrometry of Large Biomolecules
Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1989) · Science · doi:10.1126/science.2675315 · Cited by 7,634
Cited by
Extending Top-Down Mass Spectrometry to Proteins with Masses Greater Than 200 Kilodaltons
Han, X., Jin, M., Breuker, K., & McLafferty, F. W. (2006) · Science · doi:10.1126/science.1128868 · Cited by 328
Collisional Activation of Large Multiply Charged Ions Using Fourier Transform Mass Spectrometry
Senko, M. W., Speir, J. P., & McLafferty, F. W. (1994) · Analytical Chemistry · doi:10.1021/ac00090a003 · Cited by 263
Deconvolution and Database Search of Complex Tandem Mass Spectra of Intact Proteins
Liu, X., Inbar, Y., Dorrestein, P. C., Wynne, C., Edwards, N., Souda, P., Whitelegge, J. P., Bafna, V., & Pevzner, P. A. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.002766 · Cited by 170
Roberts, D. S., Loo, J. A., Tsybin, Y. O., Liu, X., Wu, S., Chamot-Rooke, J., Agar, J. N., Paša-Tolić, L., Smith, L. M., & Ge, Y. (2024) · Nature Reviews Methods Primers · doi:10.1038/s43586-024-00318-2 · Cited by 161
Self-citationProtein Identification Using Top-Down Spectra
Liu, X., Sirotkin, Y., Shen, Y., Anderson, G., Tsai, Y. S., Ting, Y. S., Goodlett, D. R., Smith, R. D., Bafna, V., & Pevzner, P. A. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.008524 · Cited by 153
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Metadata
- Authors
- Loo, J. A., Edmonds, C. G., & Smith, R. D.
- Venue
- Science
- Published
- 1990-04-13
- Volume
- 248
- Issue
- 4952
- Pages
- 201-204
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2023887263
- Cited by
- 300
- References
- 1
- FWCI
- 11.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Loo, J. A., Edmonds, C. G., & Smith, R. D. (1990). Primary Sequence Information from Intact Proteins by Electrospray Ionization Tandem Mass Spectrometry. Science. https://doi.org/10.1126/science.2326633
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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