The DOI matches its Crossref record.
Attomole-Sensitivity Electrospray Source for Large-Molecule Mass Spectrometry
Abstract
Full mass spectra of high resolving power are obtained from 0.2 nL sample volumes of large (> 10 kDa) nucleotides and proteins using a new electrospray ionization (ESI) system combined with Fourier transform mass spectrometry. The ESI needles are fabricated by laser-heated pulling of fused-silica tubing (5-20 microns i.d.), followed by chemical etching and surface metalization. Total analyte loaded at the instrument of 8.6 fmol and 216 amol produces signal-to-noise ratios of 400:1 and 60:1, respectively, and resolving power of > 10(5) for full mass spectra, while the total amount of material consumed is approximately 150 and 10 amol, respectively.
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Citations
Cited by
Attomole Protein Characterization by Capillary Electrophoresis-Mass Spectrometry
Valaskovic, G. A., Kelleher, N. L., & McLafferty, F. W. (1996) · Science · doi:10.1126/science.273.5279.1199 · Cited by 398
Self-citationMartin, S. E., Shabanowitz, J., Hunt, D. F., & Marto, J. A. (2000) · Analytical Chemistry · doi:10.1021/ac000497v · Cited by 276
Data storage using peptide sequences
Ng, C. C. A., Tam, W. M., Yin, H., Wu, Q., So, P.-K., Wong, M. Y.-M., Lau, F. C. M., & Yao, Z.-P. (2021) · Nature Communications · doi:10.1038/s41467-021-24496-9 · Cited by 41
Metadata
- Authors
- Valaskovic, G. A., Kelleher, N. L., Little, D. P., Aaserud, D. J., & McLafferty, F. W.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1995-10-01
- Volume
- 67
- Issue
- 20
- Pages
- 3802-3805
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2015153974
- Cited by
- 217
- References
- 0
- FWCI
- 10.97
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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