Data storage using peptide sequences
Open accessAbstract
Humankind is generating digital data at an exponential rate. These data are typically stored using electronic, magnetic or optical devices, which require large physical spaces and cannot last for a very long time. Here we report the use of peptide sequences for data storage, which can be durable and of high storage density. With the selection of suitable constitutive amino acids, designs of address codes and error-correction schemes to protect the order and integrity of the stored data, optimization of the analytical protocol and development of a software to effectively recover peptide sequences from the tandem mass spectra, we demonstrated the feasibility of this method by successfully storing and retrieving a text file and the music file Silent Night with 40 and 511 18-mer peptides respectively. This method for the first time links data storage with the peptide synthesis industry and proteomics techniques, and is expected to stimulate the development of relevant fields.
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Apart from DNA, other organic molecules have been proposed for data storage, including peptide sequences and urethanes.
“Apart from DNA, other organic molecules have been recently proposed.133,134 Two interesting examples are the use of peptide sequences for data storage, as reported by Ng et al.133 and the use of urethanes as reported by Dahlhauser et al.134”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [133]
In both peptide and urethane data storage cases, reading required the use of mass spectroscopy, with consequent limitations in costs and speed.
“Unfortunately in both these cases, reading required the use of mass spectroscopy, with the consequent limitation in terms of costs and speed.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [133]
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Self-citation
- Authors
- Ng, C. C. A., Tam, W. M., Yin, H., Wu, Q., So, P.-K., Wong, M. Y.-M., Lau, F. C. M., & Yao, Z.-P.
- Affiliations
- Hong Kong Polytechnic University (HK)
- Corresponding author
- Lau, Francis C. M.
- Yao, Zhong-Ping
- Venue
- Nature Communications
- Published
- 2021-07-13
- Volume
- 12
- Issue
- 1
- Pages
- 4242-4242
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC8277807
- OpenAlex
- W3173530340
- Cited by
- 41
- References
- 41
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 8 · 2023: 6 · 2022: 11 · 2021: 1
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- PolyU Institutional Research Archive (Hong Kong Polytechnic University) (submittedVersion, cc-by)
- Funders
- National Natural Science Foundation of China (81874306, 81601828)
- Jinan University
- Hong Kong Polytechnic University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Biological Computing
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Physical Sciences › Computer Science › Artificial Intelligence › Algorithms and Data Compression
- Keywords
- peptide sequences, data storage density, error correction, address codes, tandem mass spectrometry, peptide synthesis, long-term data preservation
- MeSH terms
- Algorithms, Animals, Humans, Software, Databases, Protein, Proteomics
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