The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Microfluidic Temperature Gradient Focusing
Abstract
A new technique is described for the concentration and separation of ionic species in solution within microchannels or capillaries. Concentration is achieved by balancing the electrophoretic velocity of an analyte against the bulk flow of solution in the presence of a temperature gradient. With an appropriate buffer, the temperature gradient can generate a corresponding gradient in the electrophoretic velocity, so that the electrophoretic and bulk velocities sum to zero at a unique point, and the analyte will be focused at that point. The technique is demonstrated for a variety of analytes, including fluorescent dyes, amino acids, DNA, proteins, and particles, and is shown to be capable of greater than 10,000-fold concentration of a dilute analyte.
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Citations
Cites
Dispersion of soluble matter in solvent flowing slowly through a tube
Taylor, G. I. (1953) · Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences · doi:10.1098/rspa.1953.0139 · Cited by 5,109
Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip
Harrison, D. J., Fluri, K., Seiler, K., Fan, Z., Effenhauser, C. S., & Manz, A. (1993) · Science · doi:10.1126/science.261.5123.895 · Cited by 1,800
Exceeding 5000-Fold Concentration of Dilute Analytes in Micellar Electrokinetic Chromatography
Quirino, J. P., & Terabe, S. (1998) · Science · doi:10.1126/science.282.5388.465 · Cited by 644
Woolley, A. T., & Mathies, R. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11348 · Cited by 605
Fabrication of Plastic Microfluid Channels by Imprinting Methods
Martynova, L., Locascio, L. E., Gaitan, M., Kramer, G. W., Christensen, R. G., & MacCrehan, W. A. (1997) · Analytical Chemistry · doi:10.1021/ac970558y · Cited by 533
Self-citationHeterogeneity within MALDI Samples As Revealed by Mass Spectrometric Imaging
Garden, R. W., & Sweedler, J. V. (2000) · Analytical Chemistry · doi:10.1021/ac9908997 · Cited by 187
Cited by
Chen, Y., Guo, Z., Wang, X., & Qiu, C. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.10.026 · Cited by 316
Thermophoresis: moving particles with thermal gradients
Piazza, R. (2008) · Soft Matter · doi:10.1039/b805888c · Cited by 268
Metadata
- Authors
- Ross, D., & Locascio, L. E.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-04-26
- Volume
- 74
- Issue
- 11
- Pages
- 2556-2564
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2007133335
- Cited by
- 278
- References
- 6
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
