The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Pinched Flow Fractionation: Continuous Size Separation of Particles Utilizing a Laminar Flow Profile in a Pinched Microchannel
Abstract
A concept of "pinched flow fractionation" for the continuous size separation and analysis of particles in microfabricated devices has been proposed and demonstrated. In this method, particles suspended in liquid were continuously introduced into a microchannel having a pinched segment and were aligned to one sidewall in the pinched segment by another liquid flow without particles. The particles were then separated perpendicularly to the flow direction according to their sizes by the spreading flow profile inside the microchannel. Polymer microbeads were successfully separated, and the effects of the flow rate and channel shapes on the separation performance were examined. Also, separated particles were collected independently by making branches at the end of the pinched segment. Since this method utilizes only the laminar flow profile inside a microchannel, complicated outer field control could be eliminated, which is usually required for other kinds of particle separation methods such as field flow fractionation. Also, this method can be applied both for particle size analysis and for preparation of monodispersed particles, since separation can be rapidly and continuously performed.
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Cites
Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane)
Duffy, D. C., McDonald, J. C., Schueller, O. J. A., & Whitesides, G. M. (1998) · Analytical Chemistry · doi:10.1021/ac980656z · Cited by 5,288
Micro Total Analysis Systems. 1. Introduction, Theory, and Technology
Reyes, D. R., Iossifidis, D., Auroux, P.-A., & Manz, A. (2002) · Analytical Chemistry · doi:10.1021/ac0202435 · Cited by 2,191
Micro Total Analysis Systems. 2. Analytical Standard Operations and Applications
Auroux, P.-A., Iossifidis, D., Reyes, D. R., & Manz, A. (2002) · Analytical Chemistry · doi:10.1021/ac020239t · Cited by 1,532
Field-Flow Fractionation: Analysis of Macromolecular, Colloidal, and Particulate Materials
Giddings, J. C. (1993) · Science · doi:10.1126/science.8502990 · Cited by 1,141
Cited by
Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications
Mark, D., Haeberle, S., Roth, G., von Stetten, F., & Zengerle, R. (2010) · Chemical Society Reviews · doi:10.1039/b820557b · Cited by 1,647
Point-of-Care Diagnostics for Global Health
Yager, P., Domingo, G. J., & Gerdes, J. (2008) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.10.061807.160524 · Cited by 1,076
Microfluidics for cell separation
Bhagat, A. A. S., Bow, H., Hou, H. W., Tan, S. J., Han, J., & Lim, C. T. (2010) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-010-0611-4 · Cited by 632
Hydrodynamic mechanisms of cell and particle trapping in microfluidics
Karimi, A., Yazdi, S., & Ardekani, A. M. (2013) · Biomicrofluidics · doi:10.1063/1.4799787 · Cited by 384
Inertial microfluidics for continuous particle filtration and extraction
Bhagat, A. A. S., Kuntaegowdanahalli, S. S., & Papautsky, I. (2009) · Microfluidics and Nanofluidics · doi:10.1007/s10404-008-0377-2 · Cited by 334
Metadata
- Authors
- Yamada, M., Nakashima, M., & Seki, M.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-08-12
- Volume
- 76
- Issue
- 18
- Pages
- 5465-5471
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2089919997
- Cited by
- 746
- References
- 4
- FWCI
- 10.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yamada, M., Nakashima, M., & Seki, M. (2004). Pinched Flow Fractionation: Continuous Size Separation of Particles Utilizing a Laminar Flow Profile in a Pinched Microchannel. Analytical Chemistry. https://doi.org/10.1021/ac049863r
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