The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Label-Free Protein Biosensor Based on Aptamer-Modified Carbon Nanotube Field-Effect Transistors
Abstract
We have fabricated label-free protein biosensors based on aptamer-modified carbon nanotube field-effect transistors (CNT-FETs) for the detection of immunoglobulin E (IgE). After the covalent immobilization of 5'-amino-modified 45-mer aptamers on the CNT channels, the electrical properties of the CNT-FETs were monitored in real time. The introduction of target IgE at various concentrations caused a sharp decrease in the source-drain current, and a gradual saturation was observed at lower concentrations. The amount of the net source-drain current before and after IgE introduction on the aptamer-modified CNT-FETs increased as a function of IgE concentration. The detection limit for IgE was determined as 250 pM. We have also prepared CNT-FET biosensors using a monoclonal antibody against IgE (IgE-mAb). The electrical properties of the aptamer- and antibody-modified CNT-FETs were compared. The performance of aptamer-modified CNT-FETs provided better results than the ones obtained using IgE-mAb-modified CNT-FETs under similar conditions. Thus, we suggest that the aptamer-modified CNT-FETs are promising candidates for the development of label-free protein biosensors.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Drummond, T. G., Hill, M. G., & Barton, J. K. (2003) · Nature Biotechnology · doi:10.1038/nbt873 · Cited by 2,214
Cited by
Electrically-Transduced Chemical Sensors Based on Two-Dimensional Nanomaterials
Meng, Z., Stolz, R. M., Mendecki, L., & Mirica, K. A. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00311 · Cited by 773
Supersensitive, Fast‐Response Nanowire Sensors by Using Schottky Contacts
Hu, Y., Zhou, J., Yeh, P., Li, Z., Wei, T., & Wang, Z. L. (2010) · Advanced Materials · doi:10.1002/adma.201000278 · Cited by 346
Flexible nanoporous tunable electrical double layer biosensors for sweat diagnostics
Munje, R. D., Muthukumar, S., Panneer Selvam, A., & Prasad, S. (2015) · Scientific Reports · doi:10.1038/srep14586 · Cited by 138
Effect of Nanowire Number, Diameter, and Doping Density on Nano-FET Biosensor Sensitivity
Li, J., Zhang, Y., To, S., You, L., & Sun, Y. (2011) · ACS Nano · doi:10.1021/nn202182p · Cited by 138
Detection of Orexin A Neuropeptide in Biological Fluids Using a Zinc Oxide Field Effect Transistor
Hagen, J., Lyon, W., Chushak, Y., Tomczak, M., Naik, R., Stone, M., & Kelley-Loughnane, N. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn300159e · Cited by 22
Metadata
- Authors
- Maehashi, K., Katsura, T., Kerman, K., Takamura, Y., Matsumoto, K., & Tamiya, E.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-12-09
- Volume
- 79
- Issue
- 2
- Pages
- 782-787
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2030205465
- Cited by
- 660
- References
- 1
- FWCI
- 14.86
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Label-Free Protein Biosensor Based on Aptamer-Modified Carbon Nanotube Field-Effect Transistors. https://app.cochat.ai/papers/10.1021/ac060830g
- The paper
- Maehashi, K., Katsura, T., Kerman, K., Takamura, Y., Matsumoto, K., & Tamiya, E. (2007). Label-Free Protein Biosensor Based on Aptamer-Modified Carbon Nanotube Field-Effect Transistors. Analytical Chemistry. https://doi.org/10.1021/ac060830g
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
