The DOI matches its Crossref record.
Application of Liquid Chromatography/Quadrupole-Linear Ion Trap Mass Spectrometry and Time-of-Flight Mass Spectrometry to the Determination of Pharmaceuticals and Related Contaminants in Wastewater
Abstract
This paper describes an enhanced liquid chromatography-mass spectrometry (LC-MS) strategy for the analysis of a selected group of 56 organic pollutants in wastewater. This group comprises 38 pharmaceuticals and 10 of their most frequent metabolites, 6 pesticides, and 2 disinfectants. The LC-MS methodology applied is based in the use of a hybrid triple-quadrupole linear ion trap mass spectrometer (QTRAP) in combination with time-of-flight mass spectrometry (TOF-MS). The join application of both techniques provided very good results in terms of accurate quantification and unequivocal confirmation. Quantification was performed by LC-QTRAP-MS operating under selected reaction monitoring (SRM) mode in both positive and negative electrospray ionization. Unequivocal identification was provided by the acquisition of three SRM transitions per compound in most of the cases and by LC-TOF-MS analysis, which allows obtaining accurate mass measurements of the identified compounds with errors lower than 2 ppm. Additionally, the use of TOF-MS permits retrospective analysis, since the full spectrum is recorded at all times with a high sensitivity. Thus, review of recorded chromatograms looking for new compounds or transformation products suspected to be present in the samples is feasible allowing one to increase the scope of the method along the monitoring program. The analytical performance of the quantitative LC-QTRAP-MS method was evaluated in effluent wastewater samples. Linearity of response over 3 orders of magnitude was demonstrated for most compounds (R(2) > 0.99). Method limits of detection were between 0.04 and 50 ng L(-1). Finally, the methodology was successfully applied to a monitoring study intended to characterize wastewater effluents of six sewage treatment plants in Spain. The presence of most of compounds was detected at concentrations ranging from 9 ng L(-1) (atrazine) to 15 microg L(-1) (paraxanthine).
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Citations
Cited by
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Van Doorslaer, X., Dewulf, J., Van Langenhove, H., & Demeestere, K. (2014) · Science of The Total Environment · doi:10.1016/j.scitotenv.2014.08.075 · Cited by 819
Krauss, M., Singer, H., & Hollender, J. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3608-9 · Cited by 743
Wastewater-based epidemiology biomarkers: Past, present and future
Choi, P. M., Tscharke, B. J., Donner, E., O'Brien, J. W., Grant, S. C., Kaserzon, S. L., Mackie, R., O'Malley, E., Crosbie, N. D., Thomas, K. V., et al. (2018) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2018.06.004 · Cited by 486
Bueno, M. J. M., Gomez, M. J., Herrera, S., Hernando, M. D., Agüera, A., & Fernández-Alba, A. R. (2012) · Environmental Pollution · doi:10.1016/j.envpol.2012.01.038 · Cited by 465
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Trovó, A. G., Nogueira, R. F. P., Agüera, A., Fernandez-Alba, A. R., Sirtori, C., & Malato, S. (2009) · Water Research · doi:10.1016/j.watres.2009.04.006 · Cited by 356
Self-citationMiranda-García, N., Suárez, S., Sánchez, B., Coronado, J. M., Malato, S., & Maldonado, M. I. (2011) · Applied Catalysis B: Environmental · doi:10.1016/j.apcatb.2011.01.030 · Cited by 323
Trovó, A. G., Nogueira, R. F. P., Agüera, A., Sirtori, C., & Fernández-Alba, A. R. (2009) · Chemosphere · doi:10.1016/j.chemosphere.2009.09.065 · Cited by 323
Self-citationPrieto-Rodríguez, L., Oller, I., Klamerth, N., Agüera, A., Rodríguez, E. M., & Malato, S. (2013) · Water Research · doi:10.1016/j.watres.2012.11.002 · Cited by 306
Self-citationKlamerth, N., Rizzo, L., Malato, S., Maldonado, M. I., Agüera, A., & Fernández-Alba, A. R. (2010) · Water Research · doi:10.1016/j.watres.2009.09.059 · Cited by 302
Self-citationde Oliveira, M., Frihling, B. E. F., Velasques, J., Filho, F. J. C. M., Cavalheri, P. S., & Migliolo, L. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135568 · Cited by 258
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Metadata
- Authors
- Martínez Bueno, M. J., Agüera, A., Gómez, M. J., Hernando, M. D., García-Reyes, J. F., & Fernández-Alba, A. R.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-11-15
- Volume
- 79
- Issue
- 24
- Pages
- 9372-9384
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2069539977
- Cited by
- 312
- References
- 0
- FWCI
- 22.24
- Type
- journal article
- Language
- en
- Open access
- closed
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