Signal Enhancement in Antibody Microarrays Using Quantum Dots Nanocrystals: Application to Potential Alzheimer’s Disease Biomarker Screening
Abstract
The performance of cadmium-selenide/zinc-sulfide (CdSe@ZnS) quantum dots (QDs) and the fluorescent dye Alexa 647 as reporter in an assay designed to detect apolipoprotein E (ApoE) has been compared. The assay is a sandwich immunocomplex microarray that functions via excitation by visible light. ApoE was chosen for its potential as a biomarker for Alzheimer's disease. The two versions of the microarray (QD or Alexa 647) were assessed under the same experimental conditions and then compared to a conventional enzyme-linked immunosorbent assay (ELISA) targeting ApoE. The QDs proved to be highly effective reporters in the microarrays, although their performance strongly varied in function of the excitation wavelength. At 633 nm, the QD microarray gave a limit of detection (LOD) of ~247 pg mL(-1); however, at an excitation wavelength of 532 nm, it provided a LOD of ~62 pg mL(-1), five times more sensitive than that of the Alexa microarray (~307 pg mL(-1)) and seven times more than that of the ELISA (~470 pg mL(-1)). Finally, serial dilutions from a human serum sample were assayed with high sensitivity and acceptable precision and accuracy.
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A minimal volume of human serum was sufficient for assay with high sensitivity and good precision.
“A minimal volume of human serum was sufficient for assay with high sensitivity and good precision.”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [115]
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- Authors
- Morales-Narváez, E., Montón, H., Fomicheva, A., & Merkoçi, A.
- Affiliations
- Nanobioelectronics & Biosensors Group, Catalan Institute of Nanotechnology, 08193, Bellaterra, Barcelona, Spain
- Universitat Autònoma de Barcelona (ES)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Corresponding author
- Merkoçi, Arben
- ORCID
- Merkoçi, Arben
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-07-09
- Volume
- 84
- Issue
- 15
- Pages
- 6821-6827
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2330767905
- Cited by
- 79
- References
- 38
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 3 · 2017: 6 · 2016: 2 · 2015: 10 · 2014: 10 · 2013: 11 · 2012: 1
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Analytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universidad de Alicante
- Ministerio de Ciencia e Innovación
- Universitat de Barcelona
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced Biosensing Techniques and Applications
- Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Keywords
- quantum dots, CdSe/ZnS, antibody microarrays, apolipoprotein E, Alzheimer's disease biomarkers, sandwich immunoassay, signal amplification, Alexa 647, excitation wavelength, detection limit, human serum, ELISA comparison
- MeSH terms
- Alzheimer Disease, Antibodies, Apolipoproteins E, Fluorescent Dyes, Humans, Immunoassay, Sulfides, Biomarkers, Zinc Compounds, Selenium Compounds, Cadmium Compounds, Protein Array Analysis, Quantum Dots
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