Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
Abstract
A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2-6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.
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Recently, multiple studies have shown that reduced levels of platelet-derived growth factors (PDGFs) in plasma significantly correlate with mild cognitive impairment and have proposed PDGFs as a potential biomarker for AD.
“Recently, multiple studies have shown that reduced levels of platelet-derived growth factors (PDGFs) in plasma significantly correlate with mild cognitive impairment and have proposed PDGFs as a potential biomarker for AD [95, 96].”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [96]
Ray et al. found 18 signalling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control patients with close to 90% accuracy and to identify patients with mild cognitive impairment that progressed to AD 2-6 years later.
“Ray et al.[145] have found 18 signalling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control patients with close to 90% accuracy and to identify patients with mild cognitive impairment that progressed to AD 2–6 years later.”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [145]
Biological analysis of the 18 proteins points to systemic deregulation of haematopoiesis, immune responses, apoptosis and neuronal support in pre-symptomatic AD.
“Biological analysis of the 18 proteins points to systemic deregulation of haematopoiesis, immune responses, apoptosis and neuronal support in pre-symptomatic AD [145].”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [145]
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- Authors
- Ray, S., Britschgi, M., Herbert, C., Takeda-Uchimura, Y., Boxer, A., Blennow, K., Friedman, L. F., Galasko, D. R., Jutel, M., Karydas, A., Kaye, J. A., Leszek, J., Miller, B. L., Minthon, L., Quinn, J. F., Rabinovici, G. D., Robinson, W. H., Sabbagh, M. N., So, Y. T., Sparks, D. L., Tabaton, M., Tinklenberg, J., Yesavage, J. A., Tibshirani, R., & Wyss-Coray, T.
- Affiliations
- Stanford Medicine (US)
- Sahlgrenska University Hospital (SE)
- University of California San Diego (US)
- Wroclaw Medical University (PL)
- Oregon Health & Science University (US)
- Lund University (SE)
- University of Genoa (IT)
- ORCID
- Venue
- Nature Medicine
- Published
- 2007-10-14
- Volume
- 13
- Issue
- 11
- Pages
- 1359-1362
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2017260345
- Cited by
- 1,048
- References
- 6
- Citations by year
- 2026: 11 · 2025: 26 · 2024: 27 · 2023: 30 · 2022: 40 · 2021: 41 · 2020: 36 · 2019: 34 · 2018: 47 · 2017: 48 · 2016: 56 · 2015: 63 · 2014: 77 · 2013: 95 · 2012: 94
- FWCI
- 51.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- National Institute on Aging (AG 08017, AG05131, AG20603, P50AG005131, R01AG020603, P30AG008017)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, biomarkers, mild cognitive impairment, disease progression prediction, immune response, apoptosis, blood-based diagnosis
- MeSH terms
- Alzheimer Disease, Cognition Disorders, Humans, Phenotype, Predictive Value of Tests, Biomarkers, Intercellular Signaling Peptides and Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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