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Negative Enrichment of Circulating Tumor Cells Using a Geometrically Activated Surface Interaction Chip
Abstract
Circulating tumor cells (CTCs) have attracted a great deal of attention, as they can be exploited to investigate metastasis. The molecular and cellular characteristics of these cells are little understood because they are rare and difficult to isolate. Many methods of isolation have centered on affinity-based positive enrichment (i.e., capturing target cells and eluting nontarget cells) using epithelial cell adhesion molecule (EpCAM) antibodies. It is known, however, that not all CTCs express the EpCAM antigen because they are heterogeneous by nature. In addition, negative enrichment (i.e., capturing nontarget cells and eluting target cells) has advantages over positive enrichment in isolating CTCs since the former can collect the target cells in an intact form. In this paper, we introduce a geometrically activated surface interaction (GASI) chip with an asymmetric herringbone structure designed to generate enhanced mixing flows, increasing the surface interaction between the nontarget cells and the channel surface. CD45 antibodies were immobilized inside the channel to capture leukocytes and release CTCs to the outlet. Blood samples from breast, lung, and gastric cancer patients were analyzed. The number of isolated CTCs varied from 1 to 51 in 1 mL of blood. Because our device does not require any labeling processes (e.g., EpCAM antibodies), intact and heterogeneous CTCs can be isolated regardless of EpCAM expression.
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A high flow rate led to a high shear force, which detached the cell from the microchannel of the microfluidic chip.
“A high flow rate was found that led to a high shear force, which detached the cell from the microchannel of the microfluidic chip.36”
From Dynamic Halbach array magnet integrated microfluidic system for the continuous-flow separation of rare tumor cells (2019) · cites this paper as [36]
Citations
Cites
Isolation of rare circulating tumour cells in cancer patients by microchip technology
Nagrath, S., Sequist, L. V. D., Maheswaran, S., Bell, D. W., Irimia, D., Ulkus, L., Smith, M. R., Kwak, E. L., Digumarthy, S. R., Muzikansky, A., et al. (2007) · Nature · doi:10.1038/nature06385 · Cited by 3,595
Chaotic Mixer for Microchannels
Stroock, A. D., Dertinger, S. K. W., Ajdari, A., Mezić, I., Stone, H. A., & Whitesides, G. M. (2002) · Science · doi:10.1126/science.1066238 · Cited by 3,435
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
Stott, S. L., Hsu, C., Tsukrov, D. I., Yu, M., Miyamoto, D. T., Waltman, B. A., Rothenberg, S. M., Shah, A. M., Smas, M. E., Korir, G. K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012539107 · Cited by 1,657
Circulating tumor cells: approaches to isolation and characterization
Yu, M., Stott, S. L., Toner, M., Maheswaran, S., & Haber, D. A. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201010021 · Cited by 1,101
Pantel, K., Alix‐Panabières, C., & Riethdorf, S. (2009) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.44 · Cited by 652
Gorges, T. M., Tinhofer, I., Drosch, M., Röse, L., Zollner, T. M., Krahn, T., & von Ahsen, O. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-178 · Cited by 569
Barrell, M. J., Campaña, A. G., von Delius, M., Geertsema, E. M., & Leigh, D. A. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201006633 · Cited by 521
Circulating Tumor Cells and Circulating Tumor DNA
Alix‐Panabières, C., Schwarzenbach, H., & Pantel, K. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-062310-094219 · Cited by 492
Kang, J. H., Krause, S., Tobin, H., Mammoto, A., Kanapathipillai, M., & Ingber, D. E. (2012) · Lab on a Chip · doi:10.1039/c2lc40072c · Cited by 274
Rare Cell Separation and Analysis by Magnetic Sorting
Zborowski, M., & Chalmers, J. J. (2011) · Analytical Chemistry · doi:10.1021/ac200550d · Cited by 201
Lara, O., Tong, X., Zborowski, M., & Chalmers, J. J. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2004.07.007 · Cited by 200
A practical guide to the staggered herringbone mixer
Williams, M. S., Longmuir, K. J., & Yager, P. (2008) · Lab on a Chip · doi:10.1039/b802562b · Cited by 178
Prang, N. S., Preithner, S., Brischwein, K., Göster, P., Wöppel, A., Müller, J., Steiger, C., Peters, M. J., Baeuerle, P. A., & da Silva, A. J. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602310 · Cited by 143
Circulating tumor cells: the Grand Challenge
den Toonder, J. M. J. (2011) · Lab on a Chip · doi:10.1039/c0lc90100h · Cited by 138
Microsystems for the Capture of Low-Abundance Cells
Dharmasiri, U., Witek, M. A., Adams, A. A., & Soper, S. A. (2010) · Annual Review of Analytical Chemistry · doi:10.1146/annurev.anchem.111808.073610 · Cited by 132
Microvortex for focusing, guiding and sorting of particles
Hsu, C., Carlo, D. D., Chen, C., Irimia, D., & Toner, M. (2008) · Lab on a Chip · doi:10.1039/b813434k · Cited by 130
Sin, A., Murthy, S. K., Revzin, A., Tompkins, R. G., & Toner, M. (2005) · Biotechnology and Bioengineering · doi:10.1002/bit.20556 · Cited by 85
Walden, P. (1937) · Angewandte Chemie · doi:10.1002/ange.19370500102 · Cited by 84
Geng, Y., Marshall, J. R., & King, M. R. (2011) · Annals of Biomedical Engineering · doi:10.1007/s10439-011-0463-6 · Cited by 74
Separation and detection of rare cells in a microfluidic disk via negative selection
Chen, C.-L., Chen, K.-C., Pan, Y.-C., Lee, T.-P., Hsiung, L.-C., Lin, C.-M., Chen, C.-Y., Lin, C.-H., Chiang, B.-L., & Wo, A. M. (2011) · Lab Chip · doi:10.1039/c0lc00332h · Cited by 72
Self-citationMcKenney, D. W., Onodera, H., Gorman, L. Z., Mimura, T., & Rothstein, D. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.42.24949 · Cited by 62
Engineering and analysis of surface interactions in a microfluidic herringbone micromixer.
Forbes, T. P., & Kralj, J. (2012) · Lab on a Chip · doi:10.1039/c2lc40356k · Cited by 56
Li, P., Gao, Y., & Pappas, D. (2012) · Analytical Chemistry · doi:10.1021/ac302002a · Cited by 33
Circulating Tumor Cells: Detection Methods and Potential Clinical Application in Breast Cancer
Kim, S. I., & Jung, H. (2010) · Journal of Breast Cancer · doi:10.4048/jbc.2010.13.2.125 · Cited by 25
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Shields, C. W., Reyes, C. D., & López, G. P. (2015) · Lab on a Chip · doi:10.1039/c4lc01246a · Cited by 1,053
Current detection technologies for circulating tumor cells
Shen, Z., Wu, A., & Chen, X. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00803h · Cited by 433
Rare cell isolation and analysis in microfluidics
Chen, Y., Li, P., Huang, P., Xie, Y., Mai, J. D., Wang, L., Nguyen, N., & Huang, T. J. (2014) · Lab on a Chip · doi:10.1039/c3lc90136j · Cited by 314
Ali, E. S., Sharker, S. M., Islam, M. T., Khan, I. N., Shaw, S., Rahman, M. A., Uddin, S. J., Shill, M. C., Rehman, S., Das, N., et al. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.01.011 · Cited by 281
Grover, P. K., Cummins, A. G., Price, T. J., Roberts‐Thomson, I. C., & Hardingham, J. E. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu018 · Cited by 215
Enrichment and single-cell analysis of circulating tumor cells
Song, Y., Tian, T., Shi, Y., Liu, W., Zou, Y. W., Khajvand, T., Wang, S., Zhu, Z., & Yang, C. J. (2016) · Chemical Science · doi:10.1039/c6sc04671a · Cited by 170
Microfluidic technologies for circulating tumor cell isolation
Cho, H., Kim, J., Song, H., Sohn, K. Y., Jeon, M., & Han, K.-H. (2018) · The Analyst · doi:10.1039/c7an01979c · Cited by 167
Theranostic nanomedicine for cancer detection and treatment
Fan, Z., Fu, P. P., Yu, H., & Ray, P. C. (2014) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2014.01.001 · Cited by 163
Kashefi-Kheyrabadi, L., Kim, J., Chakravarty, S., Park, S., Gwak, H., Kim, S.-I., Mohammadniaei, M., Lee, M., Hyun, K.-A., & Jung, H. (2020) · Biosensors & bioelectronics · doi:10.1016/j.bios.2020.112622 · Cited by 92
Self-citationKang, Y., Kim, Y. J., Bu, J., Cho, Y.-H., Han, S., & Moon, B.-I. (2017) · Nanoscale · doi:10.1039/c7nr04557c · Cited by 146
Qian, W., Zhang, Y., & Chen, W. (2015) · Small · doi:10.1002/smll.201403658 · Cited by 135
Lin, Z., Luo, G., Du, W., Kong, T., Liu, C., & Liu, Z. (2019) · Small · doi:10.1002/smll.201903899 · Cited by 133
Kim, T. H., Wang, Y., Oliver, C. R., Thamm, D. H., Cooling, L. L. W., Paoletti, C., Smith, K. J., Nagrath, S., & Hayes, D. F. (2019) · Nature Communications · doi:10.1038/s41467-019-09439-9 · Cited by 122
Advances and critical concerns with the microfluidic enrichments of circulating tumor cells
Hyun, K.-A., & Jung, H. (2013) · Lab on a Chip · doi:10.1039/c3lc50582k · Cited by 116
Self-citationZhou, M.-D., Hao, S., Williams, A. J., Harouaka, R. A., Schrand, B., Rawal, S., Ao, Z., Brenneman, R., Gilboa, E., Lü, B., et al. (2014) · Scientific Reports · doi:10.1038/srep07392 · Cited by 110
Two-stage microfluidic chip for selective isolation of circulating tumor cells (CTCs)
Hyun, K.-A., Lee, T. Y., Lee, S. H., & Jung, H. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.07.019 · Cited by 97
Self-citationAn integrated microfluidic chip for one-step isolation of circulating tumor cells
Lee, T. Y., Hyun, K.-A., Kim, S.-I., & Jung, H.-I. (2017) · Sensors and Actuators B: Chemical · doi:10.1016/j.snb.2016.05.163 · Cited by 94
Self-citationIsolation and enrichment of circulating biomarkers for cancer screening, detection, and diagnostics
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Ruzycka-Ayoush, M., Cimpan, M. R., Ríos-Mondragón, I., & Grudziński, I. P. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0492-0 · Cited by 84
Wang, X., Gao, H., Qi, H., Gao, Q., & Zhang, C. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04359 · Cited by 80
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Leung, E. T. Y., Lee, C., Tian, X., Lam, K. K. W., Li, R., Ng, E. H. Y., Yeung, W. S. B., & Chiu, P. C. N. (2021) · Nature Reviews Urology · doi:10.1038/s41585-021-00530-9 · Cited by 75
Tang, W.-L., Jiang, D., Li, Z.-A., Zhu, L., Shi, J.-P., Yang, J.-Q., & Xiang, N. (2018) · Electrophoresis · doi:10.1002/elps.201800361 · Cited by 61
Circulating Tumor Cells Versus Circulating Tumor DNA in Colorectal Cancer: Pros and Cons
Tan, C. R. C., Zhou, L., & El‐Deiry, W. S. (2016) · Current Colorectal Cancer Reports · doi:10.1007/s11888-016-0320-y · Cited by 72
Microfluidic analysis of circulating tumor cells and tumor-derived extracellular vesicles
Tian, F., Liu, C., Lin, L., Chen, Q., & Sun, J. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.05.013 · Cited by 66
Min, H., Jo, S., & Kim, H. (2015) · Small · doi:10.1002/smll.201403126 · Cited by 65
Wang, M., Tan, Y., Li, D., Xu, G., Yin, D., Xiao, Y., Xu, T., Chen, X., Zhu, X., & Shi, X. (2021) · Advanced Fiber Materials · doi:10.1007/s42765-021-00075-x · Cited by 63
Novel approaches in cancer management with circulating tumor cell clusters
Rostami, P., Kashaninejad, N., Moshksayan, K., Saidi, M. S., Firoozabadi, B., & Nguyen, N. (2019) · Journal of Science Advanced Materials and Devices · doi:10.1016/j.jsamd.2019.01.006 · Cited by 65
Huang, L. J., Bian, S., Cheng, Y., Shi, G., Liu, P., Ye, X., & Wang, W. (2017) · Biomicrofluidics · doi:10.1063/1.4975666 · Cited by 62
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Chen, F., Wang, S., Fang, Y., Zheng, L., Zhi, X., Cheng, B., Chen, Y., Zhang, C., Shi, D., Song, H., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13823 · Cited by 59
Shi, W., Wang, S., Maarouf, A., Uhl, C. G., He, R., Yunus, D. E., & Liu, Y. (2017) · Lab on a Chip · doi:10.1039/c7lc00333a · Cited by 58
Recent advances in microfluidic methods in cancer liquid biopsy
Iliescu, F. S., Poenar, D. P., Yu, F., Ni, M., Chan, K. H., Cima, I., Taylor, H. K., Cima, I., & Iliescu, C. (2019) · Biomicrofluidics · doi:10.1063/1.5087690 · Cited by 51
Chu, C., Liu, R., Ozkaya‐Ahmadov, T., Boya, M., Swain, B. E., Owens, J. M., Burentugs, E., Bilen, M. A., McDonald, J. F., & Sarioglu, A. F. (2019) · Lab on a Chip · doi:10.1039/c9lc00575g · Cited by 53
Efficient microfluidic negative enrichment of circulating tumor cells in blood using roughened PDMS
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Some, S., Sohn, J. S., Kim, J., Lee, S.-H., Lee, S. C., Lee, J., Shackery, I., Kim, S. K., Ys, K., Choi, N., et al. (2016) · Scientific Reports · doi:10.1038/srep20015 · Cited by 50
Self-citationWu, X., Xiao, T., Luo, Z., He, R., Cao, Y., Guo, Z., Zhang, W., & Chen, Y. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0390-x · Cited by 50
Turetta, M., Ben, F. D., Brisotto, G., Biscontin, E., Bulfoni, M., Cesselli, D., Colombatti, A., Scoles, G., Gigli, G., & del Mercato, L. L. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180605122633 · Cited by 46
Chen, L., Wu, L., Zhang, Z., Hu, J., Tang, M., Qi, C., Li, N., & Pang, D. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.05.071 · Cited by 44
Dao, T. N. T., Lee, E. Y., Koo, B., Jin, C. E., Lee, T. Y., & Shin, Y. M. (2017) · Analytical Biochemistry · doi:10.1016/j.ab.2017.12.030 · Cited by 44
Self-citationKo, J., Bhagwat, N., Yee, S. S., Black, T. A., Redlinger, C., Romeo, J., O’Hara, M. H., Raj, A., Carpenter, E. L., Stanger, B. Z., et al. (2017) · Lab on a Chip · doi:10.1039/c7lc00703e · Cited by 44
A microfluidic electrochemical aptasensor for enrichment and detection of bisphenol A.
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Self-citationMicrofluidic Screening of Circulating Tumor Biomarkers toward Liquid Biopsy
Hao, N., & Zhang, J. X. J. (2017) · Separation and Purification Reviews · doi:10.1080/15422119.2017.1320763 · Cited by 43
Progress in Circulating Tumor Cell Research Using Microfluidic Devices
Gwak, H., Kim, J., Kashefi‐Kheyrabadi, L., Kwak, B., Hyun, K.-A., & Jung, H. (2018) · Micromachines · doi:10.3390/mi9070353 · Cited by 43
Self-citationApplication of Microfluidics in Detection of Circulating Tumor Cells
Li, C., He, W., Wang, N., Xi, Z., Deng, R., Liu, X., Kang, R., Xie, L., & Liu, X. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.907232 · Cited by 41
Dao, T. N. T., Yoon, J., Jin, C. E., Koo, B., Han, K., Shin, Y. M., & Lee, T. Y. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.12.190 · Cited by 38
Self-citationReal-time quantitative RT-PCR detection of circulating tumor cells from breast cancer patients
Guo, M., Li, X., Zhang, S., Song, H., Zhang, W., Shang, X., Zheng, Y., Jiang, H., Lv, Q., Jiang, Y., et al. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2732 · Cited by 36
Organ-on-a-Chip Platforms for Drug Screening and Tissue Engineering
Wang, Z., Samanipour, R., & Kim, K. (2015) · Biosystems & biorobotics · doi:10.1007/978-3-319-21813-7_10 · Cited by 35
Micro/nanofluidic technologies for efficient isolation and detection of circulating tumor cells
Yue, W.-Q., Tan, Z., Li, X.-P., Liu, F.-F., & Wang, C. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.06.009 · Cited by 34
Kwon, K., Gwak, H., Hyun, K.-A., Kwak, B., & Jung, H. (2019) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2019.05.007 · Cited by 33
Self-citationLab-on-a-chip technology and microfluidics
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Liu, Y., Li, R. Q., Zhang, L., & Guo, S. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.850241 · Cited by 31
Pappas, D. (2015) · The Analyst · doi:10.1039/c5an01778e · Cited by 32
Li, W., Zhang, Y., Reynolds, C. P., & Pappas, D. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b00377 · Cited by 30
Continuous enrichment of circulating tumor cells using a microfluidic lateral flow filtration chip
Lee, S.-W., Hyun, K.-A., Kim, S. I., Kang, J.-Y., & Jung, H. (2014) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.12.037 · Cited by 29
Self-citationBu, J., Kang, Y., Kim, Y. J., Cho, Y.-H., Chang, H. J., Kim, H., Moon, B.-I., & Kim, H. G. (2016) · Lab on a Chip · doi:10.1039/c6lc01179a · Cited by 29
Xue, M., Xiang, A., Guo, Y., Wang, L., Wang, R., Wang, W., Ji, G., & Lu, Z. (2019) · RSC Advances · doi:10.1039/c9ra08285a · Cited by 26
Zhang, H., Wang, Y., Li, Q., Zhang, F., & Tang, B. (2014) · Chemical Communications · doi:10.1039/c4cc02342k · Cited by 25
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Hao, N., Nie, Y., Tadimety, A., Shen, T., & Zhang, J. X. J. (2018) · Biomaterials Science · doi:10.1039/c8bm00851e · Cited by 21
Fu, X., Chen, B., He, M., Yuan, G., & Hu, B. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c06889 · Cited by 19
Zhao, P., Liu, Y.-Y., Chen, Y., Yang, M., Zhao, S.-X., Qi, N., Wang, Y.-Z., Huo, D., & Hou, C.-J. (2022) · ACS Applied Materials and Interfaces · doi:10.1021/acsami.2c07660 · Cited by 19
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Luo, W.-Y., Tsai, S.-C., Hsieh, K., & Lee, G.-B. (2015) · Journal of Micromechanics and Microengineering · doi:10.1088/0960-1317/25/8/084007 · Cited by 18
Kwon, K., Park, J. W., Hyun, K.-A., Kwak, B., Yong, D., Hwang, J., & Jung, H. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.04.043 · Cited by 18
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Kim, Y., Bu, J., Cho, Y.-H., Son, I. T., & Kang, S. (2016) · Journal of Micromechanics and Microengineering · doi:10.1088/1361-6439/aa53ff · Cited by 12
Goudar, V. S., Yeh, P.-H., Wu, S.-Y., Chu, C.-H., Lu, L., Yang, C.-H., Chiou, T.-J., & Tseng, F. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.128002 · Cited by 10
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Zhang, X., Hofmann, S., Rack, B. K., Harbeck, N., Jeschke, U., & Doisneau-Sixou, S. F. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061318 · Cited by 9
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Piri, A., Hyun, K., Jung, H., Nam, K. S., & Hwang, J. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.133249 · Cited by 8
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Chakraborty, S., Jaitpal, S., Acharya, S., & Paul, D. (2023) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2023.01.005 · Cited by 8
Yoon, Y., Lee, J., Yoo, K.-C., Sul, O., Lee, S.-J., & Lee, S.-B. (2018) · Micromachines · doi:10.3390/mi9030106 · Cited by 8
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Metadata
- Authors
- Hyun, K.-A., Lee, T. Y., & Jung, H.-I.
- Affiliations
- Yonsei University (KR)
- LG (South Korea) (KR)
- Corresponding author
- Lee, Tae Yoon
- Jung, Hyo-Il
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-04-09
- Volume
- 85
- Issue
- 9
- Pages
- 4439-4445
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2057992135
- Cited by
- 102
- References
- 24
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 8 · 2021: 3 · 2020: 4 · 2019: 13 · 2018: 15 · 2017: 13 · 2016: 13 · 2015: 10 · 2014: 10 · 2013: 2
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Analytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- circulating tumor cells, CTC heterogeneity, breast cancer, lung cancer, gastric cancer, metastasis, label-free cell isolation
- MeSH terms
- Humans, Neoplastic Cells, Circulating, Surface Properties, Cell Line, Tumor, Microfluidic Analytical Techniques, MCF-7 Cells
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