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MALDI-FTICR Imaging Mass Spectrometry of Drugs and Metabolites in Tissue
Open accessAbstract
A new approach is described for imaging mass spectrometry analysis of drugs and metabolites in tissue using matrix-assisted laser desorption ionization-Fourier transform ion cyclotron resonance (MALDI-FTICR). The technique utilizes the high resolving power to produce images from thousands of ions measured during a single mass spectrometry (MS)-mode experiment. Accurate mass measurement provides molecular specificity for the ion images on the basis of elemental composition. Final structural confirmation of the targeted compound is made from accurate mass fragment ions generated in an external quadrupole-collision cell. The ability to image many small molecules in a single measurement with high specificity is a significant improvement over existing MS/MS based technologies. Example images are shown for olanzapine in kidney and liver and imatinib in glioma.
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Cited by
A concise review of mass spectrometry imaging
Amstalden van Hove, E. R., Smith, D. F., & Heeren, R. M. A. (2010) · Journal of Chromatography A · doi:10.1016/j.chroma.2010.01.033 · Cited by 416
MALDI Imaging of Lipid Biochemistry in Tissues by Mass Spectrometry
Zemski Berry, K. A., Hankin, J. A., Barkley, R. M., Spraggins, J. M., Caprioli, R. M., & Murphy, R. C. (2011) · Chemical Reviews · doi:10.1021/cr200280p · Cited by 386
Self-citationBioimaging of metals by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
Becker, J. S., Zoriy, M., Matusch, A., Wu, B., Salber, D., Palm, C., & Becker, J. S. (2010) · Mass Spectrometry Reviews · doi:10.1002/mas.20239 · Cited by 287
Mass spectrometry imaging for drug distribution studies
Prideaux, B., & Stoeckli, M. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.07.028 · Cited by 279
Proteomic analysis of formalin-fixed paraffin-embedded tissue by MALDI imaging mass spectrometry
Casadonte, R., & Caprioli, R. M. (2011) · Nature Protocols · doi:10.1038/nprot.2011.388 · Cited by 279
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Metadata
- Authors
- Cornett, D. S., Frappier, S. L., & Caprioli, R. M.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-06-20
- Volume
- 80
- Issue
- 14
- Pages
- 5648-5653
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2165553407
- Cited by
- 343
- References
- 0
- FWCI
- 11.55
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: MALDI-FTICR Imaging Mass Spectrometry of Drugs and Metabolites in Tissue. https://app.cochat.ai/papers/10.1021/ac800617s
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- Cornett, D. S., Frappier, S. L., & Caprioli, R. M. (2008). MALDI-FTICR Imaging Mass Spectrometry of Drugs and Metabolites in Tissue. Analytical Chemistry. https://doi.org/10.1021/ac800617s
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