The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
A New Dynamic in Mass Spectral Imaging of Single Biological Cells
Abstract
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) has unique capabilities in the area of high-resolution mass spectrometric imaging of biological samples. The technique offers parallel detection of native and non-native molecules at physiological concentrations with potentially submicrometer spatial resolution. Recent advances in SIMS technology have been focused on generating new ion sources that can in turn be used to eject more intact molecular and biological characteristic species from a sample. The introduction of polyatomic ion beams, particularly C60, for TOF-SIMS analysis has created a whole new application of molecular depth profiling and 3D molecular imaging. However, such analyses, particularly at high lateral resolution, are severely hampered by the accompanying mass spectrometry associated with current TOF-SIMS instruments. Hence, we have developed an instrument that overcomes many of the drawbacks of current TOF-SIMS spectrometers by removing the need to pulse the primary ion beam. The instrument samples the secondary ions using a buncher that feeds into a specially designed time-of-flight analyzer. We have validated this new instrumental concept by analyzing a number of biological samples generating 2D and 3D images showing molecular localization on a subcellular scale, over a practical time frame, while maintaining high mass resolution. We also demonstrate large area mapping and the MS/MS capability of the instrument.
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Cites
Weibel, D., Wong, S., Lockyer, N., Blenkinsopp, P., Hill, R., & Vickerman, J. C. (2003) · Analytical Chemistry · doi:10.1021/ac026338o · Cited by 543
Self-citationTouboul, D., Kollmer, F., Niehuis, E., Brunelle, A., & Laprévote, O. (2005) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2005.06.005 · Cited by 364
Mass Spectrometric Imaging of Highly Curved Membranes During Tetrahymena Mating
Ostrowski, S. G., Van Bell, C. T., Winograd, N., & Ewing, A. G. (2004) · Science · doi:10.1126/science.1099791 · Cited by 330
Mass Spectrometric Imaging of Lipids in Brain Tissue
Sjövall, P., Lausmaa, J., & Johansson, B. (2004) · Analytical Chemistry · doi:10.1021/ac049389p · Cited by 313
Fletcher, J. S., Lockyer, N. P., Vaidyanathan, S., & Vickerman, J. C. (2007) · Analytical Chemistry · doi:10.1021/ac061370u · Cited by 302
Self-citationDevelopment and experimental application of a gold liquid metal ion source
Davies, N., Weibel, D. E., Blenkinsopp, P., Lockyer, N., Hill, R., & Vickerman, J. C. (2003) · Applied Surface Science · doi:10.1016/s0169-4332(02)00631-1 · Cited by 223
Self-citationMahoney, C. M., Roberson, S. V., & Gillen, G. J. (2004) · Analytical Chemistry · doi:10.1021/ac035532n · Cited by 139
Jones, E. A., Lockyer, N. P., & Vickerman, J. C. (2006) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2006.09.015 · Cited by 131
Self-citationBreitenstein, D., Rommel, C. E., Möllers, R., Wegener, J., & Hagenhoff, B. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604468 · Cited by 109
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Cited by
A concise review of mass spectrometry imaging
Amstalden van Hove, E. R., Smith, D. F., & Heeren, R. M. A. (2010) · Journal of Chromatography A · doi:10.1016/j.chroma.2010.01.033 · Cited by 416
Lipid imaging with time-of-flight secondary ion mass spectrometry (ToF-SIMS)
Passarelli, M. K., & Winograd, N. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.05.007 · Cited by 314
Porta Siegel, T., Hamm, G., Bunch, J., Cappell, J., Fletcher, J. S., & Schwamborn, K. (2018) · Molecular Imaging and Biology · doi:10.1007/s11307-018-1267-y · Cited by 187
Self-citationHancock, S. E., Ding, E., Johansson Beves, E., Mitchell, T., & Turner, N. (2023) · Journal of Lipid Research · doi:10.1016/j.jlr.2023.100341 · Cited by 13
Metadata
- Authors
- Fletcher, J. S., Rabbani, S., Henderson, A., Blenkinsopp, P., Thompson, S. P., Lockyer, N. P., & Vickerman, J. C.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-10-25
- Volume
- 80
- Issue
- 23
- Pages
- 9058-9064
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2078181849
- Cited by
- 289
- References
- 17
- FWCI
- 23.11
- Type
- journal article
- Language
- en
- Open access
- closed
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