The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Quantitative Profiling Method for Oxylipin Metabolome by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry
Open accessAbstract
Cyclooxygenase, lipoxygenase, and epoxygenase derived oxylipins, especially eicosanoids, play important roles in many physiological processes. Assessment of oxidized fatty acid levels is important for understanding their homeostatic and pathophysiological roles. Most reported methods examine these pathways in isolation. The work described here employed a solid phase extraction-liquid chromatography-electrospray ionization MS/MS (SPE-LC-ESI MS/MS) method to monitor these metabolites. In 21 min, 39 oxylipins were quantified along with eight corresponding internal standards. The limits of quantification were between 0.07 and 32 pg (20 pM-10 nM). Finally, the validated method was used to evaluate oxylipin profiles in lipopolysaccharide-exposed mice, an established septic inflammatory model. The method described here offers a useful tool for the evaluation of complex regulatory oxylipin responses in in vitro or in vivo studies.
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Anti-inflammatory Properties of Cytochrome P450 Epoxygenase-Derived Eicosanoids
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Tkaczyk, A., Bownik, A., Dudka, J., Kowal, K., & Ślaska, B. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.143038 · Cited by 328
Brügger, B. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035324 · Cited by 264
Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases
Panigrahy, D., Gartung, A., Yang, J., Yang, H., Gilligan, M. M., Sulciner, M. L., Bhasin, S. S., Bielenberg, D. R., Chang, J., Schmidt, B. A., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127282 · Cited by 132
Self-citationIndividual variation in lipidomic profiles of healthy subjects in response to omega-3 Fatty acids
Nording, M. L., Yang, J., Georgi, K., Hegedus Karbowski, C., German, J. B., Weiss, R. H., Hogg, R. J., Trygg, J., Hammock, B. D., & Zivkovic, A. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076575 · Cited by 100
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Metadata
- Authors
- Yang, J., Schmelzer, K., Georgi, K., & Hammock, B. D.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-08-28
- Volume
- 81
- Issue
- 19
- Pages
- 8085-8093
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2119429228
- Cited by
- 310
- References
- 35
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Yang, J., Schmelzer, K., Georgi, K., & Hammock, B. D. (2009). Quantitative Profiling Method for Oxylipin Metabolome by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry. Analytical Chemistry. https://doi.org/10.1021/ac901282n
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