The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Influence of Matrix Solution Conditions on the MALDI-MS Analysis of Peptides and Proteins
Abstract
Sample-matrix preparation procedures are shown to greatly influence the quality of the matrix-assisted laser desorption/ionization (MALDI) mass spectra of peptides and proteins. In particular, dramatic mass discrimination effects are observed when the matrix 4-hydroxy-alpha-cyanocinnamic acid is used for analyzing complex mixtures of peptides and proteins. The discrimination effects are found to be strongly dependent on the sample-matrix solution composition, pH, and the rates at which the sample-matrix cocrystals are grown. These findings demonstrate the need to exercise great care in performing and interpreting the MALDI analysis of biological samples. The results also indicate that there is a reverse-phase chromatographic-like dimension in the sample-matrix preparation procedures that can be exploited to optimize the analysis. The present work describes the conditions under which the majority of components of a complex mixture of peptides and proteins can be successfully measured.
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Cites
Prendergast, G. C., Lawe, D., & Ziff, E. B. (1991) · Cell · doi:10.1016/0092-8674(91)90457-a · Cited by 558
Cited by
McDonnell, L. A., & Heeren, R. M. A. (2007) · Mass Spectrometry Reviews · doi:10.1002/mas.20124 · Cited by 1,082
Mühlradt, P. F., Kieß, M., Meyer, H., Süßmuth, R., & Jung, G. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.11.1951 · Cited by 396
Vinkemeier, U., Cohen, S. L., Moarefi, I., Chait, B. T., Kuriyan, J., & Darnell, J. E. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00946.x · Cited by 308
Self-citationMethods for samples preparation in proteomic research
Bodzon-Kulakowska, A., Bierczynska-Krzysik, A., Dylag, T., Drabik, A., Suder, P., Noga, M., Jarzebinska, J., & Silberring, J. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.10.040 · Cited by 254
Prodomain processing of Asp1 (BACE2) is autocatalytic
Hussain, I., Christie, G., Schneider, K., Moore, S., & Dingwall, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101069200 · Cited by 41
Metadata
- Authors
- Cohen, S. L., & Chait, B. T.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1996-01-01
- Volume
- 68
- Issue
- 1
- Pages
- 31-37
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2003593019
- Cited by
- 547
- References
- 1
- FWCI
- 18.17
- Type
- journal article
- Language
- en
- Open access
- closed
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