The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Quantitative Analysis of Molecular Interaction in a Microfluidic Channel: The T-Sensor
Abstract
The T-sensor is a recently developed microfluidic chemical measurement device that exploits the low Reynolds number flow conditions in microfabricated channels. The interdiffusion and resulting chemical interaction of components from two or more input fluid streams can be monitored optically, allowing measurement of analyte concentrations on a continuous basis. In a simple form of T-sensor, the concentration of a target analyte is determined by measuring fluorescence intensity in a region where the analyte and a fluorescent indicator have interdiffused. An analytical model has been developed that predicts device behavior from the diffusion coefficients of the analyte, indicator, and analyte--indicator complex and from the kinetics of the complex formation. Diffusion coefficients depend on the local viscosity which, in turn, depends on local concentrations of all analytes. These relationships, as well as reaction equilibria, are often unknown. A rapid method for determining these unknown parameters by interpreting T-sensor experiments through the model is presented.
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Cites
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Self-citationDiffusion-based extraction in a microfabricated device
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Self-citationTemperature Behaviour of Human Serum Albumin
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Cited by
Biomolecular gradients in cell culture systems
Keenan, T. M., & Folch, A. (2008) · Lab Chip · doi:10.1039/b711887b · Cited by 596
Lab-on-a-chip for drug development
Weigl, B. H., Bardell, R. L., & Cabrera, C. R. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00223-5 · Cited by 481
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Metadata
- Authors
- Kamholz, A. E., Weigl, B. H., Finlayson, B. A., & Yager, P.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1999-10-28
- Volume
- 71
- Issue
- 23
- Pages
- 5340-5347
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2022069856
- Cited by
- 631
- References
- 10
- FWCI
- 21.02
- Type
- journal article
- Language
- en
- Open access
- closed
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