The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Fabrication of Topologically Complex Three-Dimensional Microfluidic Systems in PDMS by Rapid Prototyping
Abstract
This paper describes a procedure for making topologically complex three-dimensional microfluidic channel systems in poly(dimethylsiloxane) (PDMS). This procedure is called the "membrane sandwich" method to suggest the structure of the final system: a thin membrane having channel structures molded on each face (and with connections between the faces) sandwiched between two thicker, flat slabs that provide structural support. Two "masters" are fabricated by rapid prototyping using two-level photolithography and replica molding. They are aligned face to face, under pressure, with PDMS prepolymer between them. The PDMS is cured thermally. The masters have complementary alignment tracks, so registration is straightforward. The resulting, thin PDMS membrane can be transferred and sealed to another membrane or slab of PDMS by a sequence of steps in which the two masters are removed one at a time; these steps take place without distortion of the features. This method can fabricate a membrane containing a channel that crosses over and under itself, but does not intersect itself and, therefore, can be fabricated in the form of any knot. It follows that this method can generate topologically complex microfluidic systems; this capability is demonstrated by the fabrication of a "basketweave" structure. By filling the channels and removing the membrane, complex microstructures can be made. Stacking and sealing more than one membrane allows even more complicated geometries than are possible in one membrane. A square coiled channel that surrounds, but does not connect to, a straight channel illustrates this type of complexity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane)
Duffy, D. C., McDonald, J. C., Schueller, O. J. A., & Whitesides, G. M. (1998) · Analytical Chemistry · doi:10.1021/ac980656z · Cited by 5,288
Self-citationMicromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip
Harrison, D. J., Fluri, K., Seiler, K., Fan, Z., Effenhauser, C. S., & Manz, A. (1993) · Science · doi:10.1126/science.261.5123.895 · Cited by 1,800
Micromachined Transducers Sourcebook
Kovacs, G. T. A. (1998) · Cited by 1,200
A controlled-release microchip
Santini, J. T., Cima, M. J., & Langer, R. (1999) · Nature · doi:10.1038/16898 · Cited by 868
Trotter, H. F., Crowell, R. H., & Fox, R. H. (1964) · The American Mathematical Monthly · doi:10.2307/2311437 · Cited by 686
Chaudhury, M. K., & Whitesides, G. M. (1991) · Langmuir · doi:10.1021/la00053a033 · Cited by 658
Self-citationEffenhauser, C. S., Bruin, G. J. M., Paulus, A., & Ehrat, M. (1997) · Analytical Chemistry · doi:10.1021/ac9703919 · Cited by 640
Ultra-High-Speed DNA Sequencing Using Capillary Electrophoresis Chips
Woolley, A. T., & Mathies, R. A. (1995) · Analytical Chemistry · doi:10.1021/ac00116a010 · Cited by 564
Microfluidic Diffusion-Based Separation and Detection
Weigl, B. H., & Yager, P. (1999) · Science · doi:10.1126/science.283.5400.346 · Cited by 502
On the aging of oxygen plasma-treated polydimethylsiloxane surfaces
Morra, M., Occhiello, E., Marola, R., Garbassi, F., Humphrey, P., & Johnson, D. (1990) · Journal of Colloid and Interface Science · doi:10.1016/0021-9797(90)90038-p · Cited by 477
Cited by
Soft Lithography in Biology and Biochemistry
Whitesides, G. M., Ostuni, E., Takayama, S., Jiang, X., & Ingber, D. E. (2001) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.3.1.335 · Cited by 2,607
Self-citationAutonomous Movement and Self-Assembly
Ismagilov, R. F., Schwartz, A., Bowden, N., & Whitesides, G. M. (2002) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20020215)41:4<652::aid-anie652>3.0.co;2-u · Cited by 601
Self-citationMicrofluidic fabrication of microparticles for biomedical applications
Li, W., Zhang, L., Ge, X., Xu, B., Zhang, W., Qu, L., Choi, C.-H., Xu, J., Zhang, A., Lee, H., et al. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00263g · Cited by 585
Chiu, D. T., Jeon, N. L., Huang, S., Kane, R. S., Wargo, C. J., Choi, I. S., Ingber, D. E., & Whitesides, G. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040562297 · Cited by 526
Self-citationVerpoorte, E., & De Rooij, N. F. (2003) · Proceedings of the IEEE · doi:10.1109/jproc.2003.813570 · Cited by 503
Lab-on-a-chip for drug development
Weigl, B. H., Bardell, R. L., & Cabrera, C. R. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00223-5 · Cited by 481
Microfluidic cell culture systems for drug research
Wu, M.-H., Huang, S.-B., & Lee, G.-B. (2010) · Lab on a Chip · doi:10.1039/b921695b · Cited by 432
Cell Culture in 3-Dimensional Microfluidic Structure of PDMS (polydimethylsiloxane)
Leclerc, E., Sakai, Y., & Fujii, T. (2003) · Biomedical Microdevices · doi:10.1023/a:1024583026925 · Cited by 324
Industrial lab-on-a-chip: Design, applications and scale-up for drug discovery and delivery
Vladisavljević, G. T., Khalid, N., Neves, M. A., Kuroiwa, T., Nakajima, M., Uemura, K., Ichikawa, S., & Kobayashi, I. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.07.017 · Cited by 313
PDMS lab-on-a-chip fabrication using 3D printed templates
Comina, G., Suska, A., & Filippini, D. (2014) · Lab Chip · doi:10.1039/c3lc50956g · Cited by 278
Synthetic Microvascular Networks for Quantitative Analysis of Particle Adhesion
Prabhakarpandian, B., Pant, K., Scott, R. C., Patillo, C. B., Irimia, D., Kiani, M. F., & Sundaram, S. (2008) · Biomedical Microdevices · doi:10.1007/s10544-008-9170-y · Cited by 68
Metadata
- Authors
- Anderson, J. R., Chiu, D. T., Jackman, R. J., Cherniavskaya, O., McDonald, J. C., Wu, H., Whitesides, S. H., & Whitesides, G. M.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-06-09
- Volume
- 72
- Issue
- 14
- Pages
- 3158-3164
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2118054369
- Cited by
- 698
- References
- 15
- FWCI
- 22.57
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
