The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
In Vivo Imaging of Endogenously Produced HClO in Zebrafish and Mice Using a Bright, Photostable Ratiometric Fluorescent Probe
Abstract
A high brightness red fluorescent probe ( S-BODIPY ) has been developed for the sensitive and specific imaging of HClO/ClO – in vitro and in vivo. This probe exhibits some distinctive features such as excellent resistance to photobleaching, a high fluorescence brightness, high selectivity, as well as a good biocompatibility. Upon oxidation of the thio-ether group into sulfoxide, the probe showed a noticeable ratiometric fluorescence response toward ClO – with fast response (within 30 s) and a low detection limit (59 nM). The probe demonstrated the successful imaging of exogenous and endogenous HClO/ClO – in living HeLa cells, zebrafish, and mice with high signal-to-noise ratios. S-BODIPY allows for the real-time monitoring the level of ClO – in living cells by ratiometric fluorescence imaging, opening up exciting prospects to develop red and even near-infrared BODIPYs with high brightness and good photostability for in vivo imaging.
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Cites
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Winterbourn, C. C. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.85 · Cited by 2,504
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Reaction-based small-molecule fluorescent probes for chemoselective bioimaging
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Oxidative stress in neurodegeneration: Cause or consequence?
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Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules
Lee, M. H., Kim, J. S., & Sessler, J. L. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00280f · Cited by 1,642
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Cited by
Qin, Z., Ren, T., Zhou, H., Zhang, X., He, L., Li, Z., Zhang, X., & Yuan, L. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202201541 · Cited by 140
Activatable Molecular Probes With Clinical Promise for NIR‐II Fluorescent Imaging
Chen, Z., Zhou, Y., Li, L., Ma, W., Li, Y., & Yang, Z. (2025) · Small · doi:10.1002/smll.202411787 · Cited by 26
Metadata
- Authors
- Duan, C., Won, M., Verwilst, P., Xu, J., Kim, H. S., Zeng, L., & Kim, J. S.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-02-20
- Volume
- 91
- Issue
- 6
- Pages
- 4172-4178
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2915371306
- Cited by
- 322
- References
- 43
- FWCI
- 17.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Duan, C., Won, M., Verwilst, P., Xu, J., Kim, H. S., Zeng, L., & Kim, J. S. (2019). In Vivo Imaging of Endogenously Produced HClO in Zebrafish and Mice Using a Bright, Photostable Ratiometric Fluorescent Probe. Analytical Chemistry. https://doi.org/10.1021/acs.analchem.9b00224
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