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Metal–Organic Framework@Porous Organic Polymer Nanocomposite for Photodynamic Therapy
Abstract
The limitation for the biomedical application of porous organic polymers (POPs) is the big size and poor dispersibility in aqueous media. Herein, a nanoscale metal–organic framework (MOF)@POP composite, named UNM, has been synthesized by epitaxial growth of the photoactive porphyrin-POPs (H 2 P-POP) on the outer surface of amine containing UiO-66 (UiO-AM). After the growth of POPs, the crystallization, pore structure, and size distribution of UNM are retained well. The formed UNM possesses a small size of less than 200 nm and could be internalized by cancer cells. Such light-activated UNM exhibits efficient ability to generate 1 O 2 under various experimental conditions, which can be further applied for PDT efficacy. The present work demonstrates the great potential of nanoscale porous polymers in biomedical fields and cancer treatment.
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Sahay, G., Alakhova, D. Y., & Kabanov, A. V. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.01.036 · Cited by 2,181
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Nanoscale metal–organic frameworks for phototherapy of cancer
Lan, G., Ni, K., & Lin, W. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.09.007 · Cited by 420
Nanoscale covalent organic frameworks: from controlled synthesis to cancer therapy
He, X., Jiang, Z., Akakuru, O. U., Li, J., & Wu, A. (2021) · Chemical Communications · doi:10.1039/d1cc04846e · Cited by 303
Multifunctional metal–organic framework heterostructures for enhanced cancer therapy
Liu, J., Huang, J., Zhang, L., & Lei, J. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00178c · Cited by 285
Kaur, H., Devi, N., Siwal, S. S., Alsanie, W. F., Thakur, M. K., & Thakur, V. K. (2023) · ACS Omega · doi:10.1021/acsomega.2c07719 · Cited by 273
Metadata
- Authors
- Zheng, X., Wang, L., Pei, Q., He, S., Liu, S., & Xie, Z.
- Venue
- Chemistry of Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-03-03
- Volume
- 29
- Issue
- 5
- Pages
- 2374-2381
- ISSN
- 0897-4756 (ISSN-L)
- 1520-5002
- OpenAlex
- W2590034771
- Cited by
- 239
- References
- 1
- FWCI
- 12.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zheng, X., Wang, L., Pei, Q., He, S., Liu, S., & Xie, Z. (2017). Metal–Organic Framework@Porous Organic Polymer Nanocomposite for Photodynamic Therapy. Chemistry of Materials. https://doi.org/10.1021/acs.chemmater.7b00228
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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