Cited by 563Metal-Catalyzed Oxygenation MechanismsGlutathione Transferases and PolymorphismsEnzyme Structure and Function

Superoxide dismutases—A review of the metal-associated mechanistic variations

Abreu, Isabel A., Cabelli, Diane E.·2010·Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Abstract

Superoxide dismutases are enzymes that function to catalytically convert superoxide radical to oxygen and hydrogen peroxide. These enzymes carry out catalysis at near diffusion controlled rate constants via a general mechanism that involves the sequential reduction and oxidation of the metal center, with the concomitant oxidation and reduction of superoxide radicals. That the catalytically active metal can be copper, iron, manganese or, recently, nickel is one of the fascinating features of this class of enzymes. In this review, we describe these enzymes in terms of the details of their catalytic properties, with an emphasis on the mechanistic differences between the enzymes. The focus here will be concentrated mainly on two of these enzymes, copper, zinc superoxide dismutase and manganese superoxide dismutase, and some relatively subtle variations in the mechanisms by which they function.

Integrity signals

Registry

Crossref · 10.1016/j.bbapap.2009.11.005

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Abreu, I. A., & Cabelli, D. E.
Affiliations
  • Universidade Nova de Lisboa (PT)
  • Brookhaven National Laboratory (US)
Corresponding author
Cabelli, Diane E.
Venue
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Publisher
Elsevier BV
Published
2010-02
Volume
1804
Issue
2
Pages
263-274
ISSN
1570-9639 (ISSN-L)
OpenAlex
W2028661305
Cited by
563
References
99
Citations by year
2026: 26 · 2025: 44 · 2024: 31 · 2023: 41 · 2022: 47 · 2021: 60 · 2020: 34 · 2019: 38 · 2018: 35 · 2017: 43 · 2016: 43 · 2015: 26 · 2014: 30 · 2013: 19 · 2012: 20
FWCI
0.29
Type
journal article
Language
en
Open access
closed
Locations
  • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Fundação para a Ciência e a Tecnologia
Topics
  • Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
  • Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
Keywords
superoxide dismutase, copper-zinc superoxide dismutase, manganese superoxide dismutase, enzyme mechanism, metalloenzyme catalysis, superoxide, hydrogen peroxide production, copper, iron, manganese, nickel, diffusion-controlled rate constants
MeSH terms
Animals, Copper, Humans, Iron, Manganese, Superoxide Dismutase, Zinc, Biocatalysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review