Ras Conformational Ensembles, Allostery, and Signaling
Lu, Shaoyong, Jang, Hyunbum, Muratcioglu, Serena, Gursoy, Attila, Keskin, Ozlem, Nussinov, Ruth, Zhang, Jian·2016·Chemical Reviews
Cites (457)
Items 401–458 of 458
- Electrostatic Effects of Mutations of Ras Glutamine 61 Measured Using Vibrational Spectroscopy of a Thiocyanate ProbeAmy J. Stafford, David M. Walker, Lauren J. Webb · 2012 · Biochemistry
- Characterization of a Ras Mutant with Identical GDP- and GTP-Bound Structures,Bradley A. Ford, Sean Boykevisch, Chen Zhao, Simone Kunzelmann, Dafna Bar‐Sagi, Christian Herrmann, Nicolas N. Nassar · 2009 · Biochemistry
- Ab Initio Study of the Role of Lysine 16 for the Molecular Switching Mechanism of Ras Protein p21Noriyuki Futatsugi, Masayuki Hata, Tyuji Hoshino, Minoru Tsuda · 1999 · Biophysical Journal
- Probing the role of loop 2 in Ras function with unnatural amino acids.H H Chung, D R Benson, Virginia W. Cornish, Peter G. Schultz · 1993 · Proceedings of the National Academy of Sciences
- Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent CompositionGenevieve Anne Holzapfel, G. Buhrman, Carla Mattos · 2012 · Biochemistry
- The Allosteric Switch and Conformational States in Ras GTPase Affected by Small MoleculesChristian William Johnson, Carla Mattos · 2013 · The Enzymes
- Growth factor receptor‐bound protein 14: a new modulator of photoreceptor‐specific cyclic‐nucleotide‐gated channelVivek Gupta, Ammaji Rajala, Roger J. Daly, Raju V. S. Rajala · 2010 · EMBO Reports
- Structural and Thermodynamic Characterization of Nore1-SARAH: A Small, Helical Module Important in Signal Transduction NetworksCihan Makbul, Diana Constantinescu-Aruxandei, Eckhard Hofmann, Daniel Schwarz, Eva Wolf, Christian Herrmann · 2013 · Biochemistry
- Relation between the Conformational Heterogeneity and Reaction Cycle of Ras: Molecular Simulation of RasChigusa Kobayashi, Shinji Saito · 2010 · Biophysical Journal
- Molecular mechanisms of asymmetric RAF dimer activationPablo G. Jambrina, Olga Bohuszewicz, Nicolae‐Viorel Buchete, Walter Kölch, Edina Rosta · 2014 · Biochemical Society Transactions
- Grb10 is a dual regulator of receptor tyrosine kinase signalingNuzhat N. Kabir, Julhash Uddin Kazi · 2014 · Molecular Biology Reports
- Combined Rational Design and a High Throughput Screening Platform for Identifying Chemical Inhibitors of a Ras-activating EnzymeChris R. Evelyn, Jacek Biesiada, Xin Duan, Hong Ming Tang, Xun Shang, Ruben Papoian, William L. Seibel, Sandra L. Nelson, Jarek Meller, Yi Zheng · 2015 · Journal of Biological Chemistry
- The Differential Effects of the Gly-60 to Ala Mutation on the Interaction of H-Ras p21 with Different Downstream TargetsMo-Chou Chen Hwang, Ying‐Ju Sung, Yu‐Wen Hwang · 1996 · Journal of Biological Chemistry
- Free Energy Diagrams for Protein FunctionRuth Nussinov, Chung‐Jung Tsai · 2014 · Chemistry & Biology
- RalGDS comes of agePablo Rodriguez‐Viciana, Frank P. McCormick · 2005 · Cancer Cell
- K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?Ruth Nussinov, Serena Muratcioğlu, Chung‐Jung Tsai, Hyunbum Jang, Attila Gürsoy, Özlem Keskin · 2015 · Expert Opinion on Therapeutic Targets
- Identification and Characterization of Mutations in Ha-Ras That Selectively Decrease Binding to cRaf-1David G. Winkler, Jeffrey C. Johnson, Jonathan A. Cooper, Anne B. Vojtek · 1997 · Journal of Biological Chemistry
- Current status of the development of Ras inhibitorsFumi Shima, Shigeyuki Matsumoto, Yoko Yoshikawa, Takashi Kawamura, Masayuki Isa, Tohru Kataoka · 2015 · The Journal of Biochemistry
- RAS’s Cloak of Invincibility Slips at Last?Julian Downward · 2014 · Cancer Cell
- The specific vibrational modes of GTP in solution and bound to Ras: a detailed theoretical analysis by QM/MM simulationsFei Xia, Till Rudack, Carsten Kötting, Jürgen Schlitter, Klaus Bernhard Gerwert · 2011 · Physical Chemistry Chemical Physics
- Structural Basis for the Interaction of the Adaptor Protein Grb14 with Activated RasRohini Qamra, Stevan R. Hubbard · 2013 · PLoS ONE
- Site-directed mutagenesis, fluorescence, and two-dimensional NMR studies on microenvironments of effector region aromatic residues of human c-Ha-Ras proteinKazuhiko Yamasaki, Mikako Shirouzu, Y. Muto, Junko Fujita‐Yoshigaki, Hiroshi Koide, Yutaka Ito, Gota Kawai, Seisuke Hattori, Shigeyuki Yokoyama · 1994 · Biochemistry
- Ras hitchhikes on PDE6δMark R. Philips · 2012 · Nature Cell Biology
- Application of Reductive 13C-Methylation of Lysines to Enhance the Sensitivity of Conventional NMR MethodsTanmay Chavan, Sherwin J. Abraham, Vadim Gaponenko · 2013 · Molecules
- Inhibiting the RAS–PI3K Pathway in Cancer TherapyClare Sheridan, Julian Downward · 2013 · The Enzymes
- Ras Regulates SCFβ-TrCP Protein Activity and Specificity via Its Effector Protein NORE1AMarianne Schmidt, Howard Donninger, Geoffrey J. Clark · 2014 · Journal of Biological Chemistry
- Parallel Allostery by cAMP and PDE Coordinates Activation and Termination Phases in cAMP SignalingSrinath Krishnamurthy, Nikhil Kumar Tulsian, Arun Chandramohan, Ganesh S. Anand · 2015 · Biophysical Journal
- Elucidating the Mode of Action of a Typical Ras State 1(T) InhibitorIna C. Rosnizeck, Daniel Filchtinski, Rui Pedro Lopes, Bärbel Kieninger, Christian Herrmann, Hans Robert Kalbitzer, Michael Spoerner · 2014 · Biochemistry
- Growth and Tumor Suppressor NORE1A Is a Regulatory Node between Ras Signaling and Microtubule NucleationChristine Bee, Anna Moshnikova, Christopher D. Mellor, Justin E. Molloy, Yulia A Koryakina, Benjamin Stieglitz, Andrei V. Khokhlatchev, Christian Herrmann · 2010 · Journal of Biological Chemistry
- Characterization of the Structural Difference between Active and Inactive Forms of the Ras Protein by Chemical Modification Followed by Mass Spectrometric Peptide MappingSatoko Akashi, Mikako Shirouzu, Tohru Terada, Yutaka Ito, Shigeyuki Yokoyama, Koji Takio · 1997 · Analytical Biochemistry
- Cu2+-cyclen as Probe to Identify Conformational States in Guanine Nucleotide Binding ProteinsTanja Meierhofer, Ina C. Rosnizeck, Thorsten Gräf, Kerstin Reiß, Burkhard König, Hans Robert Kalbitzer, Michael Spoerner · 2011 · Journal of the American Chemical Society
- The frozen solution structure of p21 ras determined by ESEEM spectroscopy reveals weak coordination of Thr35 to the active site metal ionChristian T. Farrar, Christopher J. Halkides, David J. Singel · 1997 · Structure
- Seeing is believing: Ras dimers observed in live cellsMark R. Philips, Channing J. Der · 2015 · Proceedings of the National Academy of Sciences
- The Renaissance of RasL.‐G. Milroy, Christian Ottmann · 2014 · ACS Chemical Biology
- Conserved electrostatic fields at the Ras–effector interface measured through vibrational Stark effect spectroscopy explain the difference in tilt angle in the Ras binding domains of Raf and RalGDSDavid M. Walker, Ruifei Wang, Lauren J. Webb · 2014 · Physical Chemistry Chemical Physics
- The potential of targeting Ras proteins in lung cancerFrank P. McCormick · 2015 · Expert Opinion on Therapeutic Targets
- Computational Methods for Exploration and Analysis of Macromolecular Structure and DynamicsAmarda Shehu, Ruth Nussinov · 2015 · PLoS Computational Biology
- Revisiting the structural flexibility of the complex p21ras‐GTP: The catalytic conformation of the molecular switch IIThereza A. Soares, John Holmes Miller, Tjerk P. Straatsma · 2001 · Proteins Structure Function and Bioinformatics
- Pocket of opportunityGideon E. Bollag, Chao Zhang · 2013 · Nature
- Probing the wild-type HRas activation mechanism using steered molecular dynamics, understanding the energy barrier and role of water in the activationNeeru Sharma, Uddhavesh Sonavane, Rajendra Joshi · 2014 · European Biophysics Journal
- Conformational states of human H-Ras detected by high-field EPR, ENDOR, and31P NMR spectroscopyMichael Spoerner, Thomas F. Prisner, Marina Bennati, M. M. Hertel, Norbert Weiden, Thomas Schweins, Hans Robert Kalbitzer · 2005 · Magnetic Resonance in Chemistry
- Structural Changes Induced in p21Ras upon GAP-334 Complexation as Probed by ESEEM Spectroscopy and Molecular-Dynamics SimulationChristian T. Farrar, Jianpeng Ma, David J. Singel, Christopher J. Halkides · 2000 · Structure
- Ras and Rap1 Activation of PLCɛ Lipase ActivityHironori Edamatsu, Takaya Satoh, Tohru Kataoka · 2006 · Methods in enzymology on CD-ROM/Methods in enzymology
- Success and failure on the ras pathwayFrank P. McCormick · 2007 · Cancer Biology & Therapy
- Functional analysis of domains in the Byr2 kinasePatricia Bauman, Charles F. Albright · 1998 · Biochimie
- Nucleotide Binding Affects Intrinsic Dynamics and Structural Communication in Ras GTPasesFrancesca Fanelli, Francesco Raimondi · 2013 · Current Pharmaceutical Design
- Which Ras rides the raft?Michael A. White, Richard G.W. Anderson · 2001 · Nature Cell Biology
- A novel point mutation at codon 146 of the K-ras gene in a human colorectal cancer identified by the polymerase chain reactionSatoshi Orita, Takatsugu Higashi, Yasuhito Kawasaki, Atsuko Harada, Hisanaga Igarashi, Takushi Monden, Hideki Morimoto, Takashi Shimano, Takesada Mori, Jun Miyoshi · 1991 · Virus Genes
- Recombinant expression of different mutant K-ras gene in pancreatic cancer Bxpc-3 cells and its effects on chemotherapy sensitivityTengfei Shao, Yuanting Zheng, Bei Zhao, Tao Li, Keguang Cheng, Weimin Cai · 2014 · Science China Life Sciences
- Applicability of next-generation sequencing to decalcified formalin-fixed and paraffin-embedded chronic myelomonocytic leukaemia samples.Veronica Bernard, Niklas Gebauer, T H Dinh, J. Stegemann, Alfred Christian Feller, Hartmut Merz · 2014 · Europe PMC (PubMed Central)
- Mechanism of the Exchange Reaction in HRAS from Multiscale ModelingAbhijeet Kapoor, Alex Travesset · 2014 · PLoS ONE
- In vitro Reconstitution of Activation of PLCε by Ras and Rho GTPasesNatalia Lamuño Gandarillas, Tom D. Bunney, Michelle B. Josephs, Peter Gierschik, Matilda Katan · 2008 · Methods in molecular biology
- Direct hit on mutant RASSarah E. Seton-Rogers · 2013 · Nature reviews. Cancer
- Conservation and divergence of Grb7 family of Ras-binding domainsRaju V. S. Rajala, Ammaji Rajala, Vivek Gupta · 2012 · Protein & Cell
- Backbone 1H, 13C, and 15N Resonance Assignments for the two 13 kD Ras Associating Domains (RA1 and RA2) from Phospholipase CɛRichard Harris, Tom D. Bunney, Matilda Katan, Paul C. Driscoll · 2005 · Journal of Biomolecular NMR
- Ras: structural details to guide direct targetingCarla Mattos · 2015 · Aging
- Mechanism involved in the modulation of photoreceptor-specific cyclic nucleotidegated channel by the tyrosine kinase adapter protein Grb14Vivek Gupta, Ammaji Rajala, Karla K. Rodgers, Raju V. S. Rajala · 2011 · Protein & Cell
- Ras-Associating Domain Proteins: A New Class of Cyclic Nucleotide-Gated Channel ModulatorsVivek Gupta, Ammaji Rajala, Raju V. S. Rajala · 2011 · Advances in experimental medicine and biology