The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Nonclassical Routes for Amide Bond Formation
Abstract
The present review offers an overview of nonclassical (e.g., with no pre- or in situ activation of a carboxylic acid partner) approaches for the construction of amide bonds. The review aims to comprehensively discuss relevant work, which was mainly done in the field in the last 20 years. Organization of the data follows a subdivision according to substrate classes: catalytic direct formation of amides from carboxylic and amines ( section 2 ); the use of carboxylic acid surrogates ( section 3 ); and the use of amine surrogates ( section 4 ). The ligation strategies (NCL, Staudinger, KAHA, KATs, etc.) that could involve both carboxylic acid and amine surrogates are treated separately in section 5 .
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
Sletten, E. M., & Bertozzi, C. R. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200900942 · Cited by 3,165
Peptide Coupling Reagents, More than a Letter Soup
El-Faham, A., & Albericio, F. (2011) · Chemical Reviews · doi:10.1021/cr100048w · Cited by 1,245
Lee, D. H., Granja, J. R., Martinez, J. A., Severin, K., & Ghadiri, M. R. (1996) · Nature · doi:10.1038/382525a0 · Cited by 677
Umpolung reactivity in amide and peptide synthesis
Shen, B., Makley, D. M., & Johnston, J. N. (2010) · Nature · doi:10.1038/nature09125 · Cited by 318
Evolution of amide bond formation
Joullie, M. M., & Lassen, K. M. (2010) · ARKIVOC · doi:10.3998/ark.5550190.0011.816 · Cited by 182
Cited by
Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations
Agouridas, V., El Mahdi, O., Diemer, V., Cargoët, M., Monbaliu, J.-C. M., & Melnyk, O. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00712 · Cited by 650
Green metrics in mechanochemistry
Fantozzi, N., Volle, J.-N., Porcheddu, A., Virieux, D., García, F., & Colacino, E. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00997h · Cited by 336
Amide Bond Formation Strategies: Latest Advances on a Dateless Transformation
Massolo, E., Pirola, M., & Benaglia, M. (2020) · European Journal of Organic Chemistry · doi:10.1002/ejoc.202000080 · Cited by 294
Ynamide‐Mediated Peptide Bond Formation: Mechanistic Study and Synthetic Applications
Xu, S., Jiang, D., Peng, Z., Hu, L., Liu, T., Zhao, L., & Zhao, J. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202212247 · Cited by 46
Practical N-to-C peptide synthesis with minimal protecting groups
(2023) · doi:10.1038/s42004-023-01030-0 · Cited by 27
Metadata
- Authors
- de Figueiredo, R. M., Suppo, J.-S., & Campagne, J.-M.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-09-22
- Volume
- 116
- Issue
- 19
- Pages
- 12029-12122
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2523045592
- Cited by
- 978
- References
- 5
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Nonclassical Routes for Amide Bond Formation. https://app.cochat.ai/papers/10.1021/acs.chemrev.6b00237
- The paper
- de Figueiredo, R. M., Suppo, J.-S., & Campagne, J.-M. (2016). Nonclassical Routes for Amide Bond Formation. Chemical Reviews. https://doi.org/10.1021/acs.chemrev.6b00237
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.