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Ionic-Liquid-Mediated Extraction and Separation Processes for Bioactive Compounds: Past, Present, and Future Trends
Open accessAbstract
Ionic liquids (ILs) have been proposed as promising media for the extraction and separation of bioactive compounds from the most diverse origins. This critical review offers a compilation on the main results achieved by the use of ionic-liquid-based processes in the extraction and separation/purification of a large range of bioactive compounds (including small organic extractable compounds from biomass, lipids, and other hydrophobic compounds, proteins, amino acids, nucleic acids, and pharmaceuticals). ILs have been studied as solvents, cosolvents, cosurfactants, electrolytes, and adjuvants, as well as used in the creation of IL-supported materials for separation purposes. The IL-based processes hitherto reported, such as IL-based solid-liquid extractions, IL-based liquid-liquid extractions, IL-modified materials, and IL-based crystallization approaches, are here reviewed and compared in terms of extraction and separation performance. The key accomplishments and future challenges to the field are discussed, with particular emphasis on the major lacunas found within the IL community dedicated to separation processes and by suggesting some steps to overcome the current limitations.
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Cites
What is a green solvent? A comprehensive framework for the environmental assessment of solvents
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Ionic Liquids and Their Interaction with Cellulose
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Ionic liquid processing of cellulose
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Dissolution of cellulose with ionic liquids and its application: a mini-review
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Ionic liquids as additives to enhance the extraction of antioxidants in aqueous two-phase systems
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Self-citation
Cited by
Liquid-phase microextraction – The different principles and configurations
Yamini, Y., Rezazadeh, M., & Seidi, S. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2018.06.010 · Cited by 309
Recent advances on ionic liquid uses in separation techniques
Berthod, A., Ruiz-Ángel, M. J., & Carda-Broch, S. (2018) · Journal of Chromatography A · doi:10.1016/j.chroma.2017.09.044 · Cited by 293
Microalgae as Sources of Omega-3 Polyunsaturated Fatty Acids: Biotechnological Aspects
Barta, D. G., Coman, V., & Vodnar, D. C. (2021) · Algal Research · doi:10.1016/j.algal.2021.102410 · Cited by 178
Murador, D. C., de Souza Mesquita, L. M., Vannuchi, N., Braga, A. R. C., & de Rosso, V. V. (2019) · Current Opinion in Food Science · doi:10.1016/j.cofs.2019.03.002 · Cited by 158
Fratelli, C., Burck, M., Amarante, M. C. A., & Braga, A. R. C. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.10.043 · Cited by 100
Metadata
- Authors
- Ventura, S. P. M., e Silva, F. A., Quental, M. V., Mondal, D., Freire, M. G., & Coutinho, J. A. P.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-02-02
- Volume
- 117
- Issue
- 10
- Pages
- 6984-7052
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2584163328
- Cited by
- 1,024
- References
- 6
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ventura, S. P. M., e Silva, F. A., Quental, M. V., Mondal, D., Freire, M. G., & Coutinho, J. A. P. (2017). Ionic-Liquid-Mediated Extraction and Separation Processes for Bioactive Compounds: Past, Present, and Future Trends. Chemical Reviews. https://doi.org/10.1021/acs.chemrev.6b00550
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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