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Nanoparticle-Based Immunochemical Biosensors and Assays: Recent Advances and Challenges

Farka, Zdeněk, Juřík, Tomáš, Kovář, David, Trnková, Libuše, Skládal, Petr·2017·Chemical Reviews

Abstract

We review the progress achieved during the recent five years in immunochemical biosensors (immunosensors) combined with nanoparticles for enhanced sensitivity. The initial part introduces antibodies as classic recognition elements. The optical sensing part describes fluorescent, luminescent, and surface plasmon resonance systems. Amperometry, voltammetry, and impedance spectroscopy represent electrochemical transducer methods; electrochemiluminescence with photoelectric conversion constitutes a widely utilized combined method. The transducing options function together with suitable nanoparticles: metallic and metal oxides, including magnetic ones, carbon-based nanotubes, graphene variants, luminescent carbon dots, nanocrystals as quantum dots, and photon up-converting particles. These sources merged together provide extreme variability of existing nanoimmunosensing options. Finally, applications in clinical analysis (markers, tumor cells, and pharmaceuticals) and in the detection of pathogenic microorganisms, toxic agents, and pesticides in the environmental field and food products are summarized.

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Metadata

Authors
Farka, Z., Juřík, T., Kovář, D., Trnková, L., & Skládal, P.
Venue
Chemical Reviews
Published
2017-07-28
Volume
117
Issue
15
Pages
9973-10042
ISSN
  • 0009-2665 (ISSN-L)
  • 1520-6890
OpenAlex
W2739579980
Cited by
694
References
8
FWCI
4.03
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Nanoparticle-Based Immunochemical Biosensors and Assays: Recent Advances and Challenges. https://app.cochat.ai/papers/10.1021/acs.chemrev.7b00037
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Farka, Z., Juřík, T., Kovář, D., Trnková, L., & Skládal, P. (2017). Nanoparticle-Based Immunochemical Biosensors and Assays: Recent Advances and Challenges. Chemical Reviews. https://doi.org/10.1021/acs.chemrev.7b00037

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