The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Evolution and Diversity of Assembly-Line Polyketide Synthases: Focus Review
Open accessAbstract
Assembly-line polyketide synthases (PKSs) are among the most complex protein machineries known in nature, responsible for the biosynthesis of numerous compounds used in the clinic. Their present-day diversity is the result of an evolutionary path that has involved the emergence of a multimodular architecture and further diversification of assembly-line PKSs. In this review, we provide an overview of previous studies that investigated PKS evolution and propose a model that challenges the currently prevailing view that gene duplication has played a major role in the emergence of multimodularity. We also analyze the ensemble of orphan PKS clusters sequenced so far to evaluate how large the entire diversity of assembly-line PKS clusters and their chemical products could be. Finally, we examine the existing techniques to access the natural PKS diversity in natural and heterologous hosts and describe approaches to further expand this diversity through engineering.
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Cites
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The confluence of big data and evolutionary genome mining for the discovery of natural products
Chevrette, M. G., Gavrilidou, A., Mantri, S., Selem-Mojica, N., Ziemert, N., & Barona-Gómez, F. (2021) · Natural Product Reports · doi:10.1039/d1np00013f · Cited by 66
Giant polyketide synthase enzymes in the biosynthesis of giant marine polyether toxins
Fallon, T. R., Shende, V. V., Wierzbicki, I. H., Pendleton, A. L., Watervoot, N. F., Auber, R. P., Gonzalez, D. J., Wisecaver, J. H., & Moore, B. S. (2024) · Science · doi:10.1126/science.ado3290 · Cited by 39
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Assessing and harnessing updated polyketide synthase modules through combinatorial engineering
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Application of artificial scaffold systems in microbial metabolic engineering
Liu, N., Dong, W., Yang, H., Li, J.-H., & Chiu, T.-Y. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1328141 · Cited by 16
Metadata
- Authors
- Nivina, A., Yuet, K. P., Hsu, J., & Khosla, C.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-12-15
- Volume
- 119
- Issue
- 24
- Pages
- 12524-12547
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2994786999
- Cited by
- 329
- References
- 6
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
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