The confluence of big data and evolutionary genome mining for the discovery of natural products

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Bioactive Microbial Metabolites: A Personal View

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A global atlas of the dominant bacteria found in soil

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Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products

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Enzyme promiscuity: A mechanistic and evolutionary perspective

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The big challenges of big data

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A computational framework to explore large-scale biosynthetic diversity

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Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

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Nonribosomal Peptide Synthesis—Principles and Prospects

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Minimum Information about a Biosynthetic Gene cluster

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A genomic catalog of Earth’s microbiomes

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Significance and Challenges of Big Data Research

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New developments in RiPP discovery, enzymology and engineering

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Microreact: visualizing and sharing data for genomic epidemiology and phylogeography

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COCONUT online: Collection of Open Natural Products database

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MIBiG 2.0: a repository for biosynthetic gene clusters of known function

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An integrated view of protein evolution

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A roadmap for natural product discovery based on large-scale genomics and metabolomics

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AutoMLST: an automated web server for generating multi-locus species trees highlighting natural product potential

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Natural products ? a simple model to explain chemical diversity

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Local Epidemics Gone Viral: Evolution and Diffusion of the Italian HIV-1 Recombinant Form CRF60_BC

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Oxidative Cyclization in Natural Product Biosynthesis

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The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery

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Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

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Inhibition of histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editing

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Evolutionary Implications of Bacterial Polyketide Synthases

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Detecting Sequence Homology at the Gene Cluster Level with MultiGeneBlast

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Mechanistic approaches to the study of evolution: the functional synthesis

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The antimicrobial potential of Streptomyces from insect microbiomes

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Machine learning: supervised methods

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Evolution and Diversity of Assembly-Line Polyketide Synthases

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Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria

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plantiSMASH: automated identification, annotation and expression analysis of plant biosynthetic gene clusters

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panX: pan-genome analysis and exploration

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Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora

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BiG-FAM: the biosynthetic gene cluster families database

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The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters

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The evolutionary paths towards complexity: a metabolic perspective

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Dynamic response of RNA editing to temperature in Drosophila

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Genome mining of biosynthetic and chemotherapeutic gene clusters in Streptomyces bacteria

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Cultivation and functional characterization of 79 planctomycetes uncovers their unique biology

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BiG-SLiCE: A highly scalable tool maps the diversity of 1.2 million biosynthetic gene clusters

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Natural products in soil microbe interactions and evolution

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The birth, evolution and death of metabolic gene clusters in fungi

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Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes

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A Systematic Computational Analysis of Biosynthetic Gene Cluster Evolution: Lessons for Engineering Biosynthesis

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Phylogenomics reveals subfamilies of fungal nonribosomal peptide synthetases and their evolutionary relationships

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Bacterial Secondary Metabolite Biosynthetic Potential in Soil Varies with Phylum, Depth, and Vegetation Type

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ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining

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The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery

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Biosynthetic gene clusters and the evolution of fungal chemodiversity

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Something old, something new: Conserved enzymes and the evolution of novelty in plant specialized metabolism

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Natural Products and the Gene Cluster Revolution

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Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria

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FlaGs and webFlaGs: discovering novel biology through the analysis of gene neighbourhood conservation

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Molecular evolution meets the genomics revolution

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Evolutionary dynamics of natural product biosynthesis in bacteria

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Stress-induced accumulation of DcAOX1 and DcAOX2a transcripts coincides with critical time point for structural biomass prediction in carrot primary cultures (Daucus carota L.).

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Metabolite–Enzyme Coevolution: From Single Enzymes to Metabolic Pathways and Networks

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Putting the data before the algorithm in big data addressing personalized healthcare

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Type III Polyketide Synthases: Functional Classification and Phylogenomics

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The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes

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Phylogenomic Analysis of Natural Products Biosynthetic Gene Clusters Allows Discovery of Arseno-Organic Metabolites in Model Streptomycetes

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Comparative genomics reveals phylogenetic distribution patterns of secondary metabolites in Amycolatopsis species

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A community resource for paired genomic and metabolomic data mining

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Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides

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Phylogenomic analysis of UDP‐dependent glycosyltransferases provides insights into the evolutionary landscape of glycosylation in plant metabolism

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CASSIS and SMIPS: promoter-based prediction of secondary metabolite gene clusters in eukaryotic genomes

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Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights

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A Machine Learning Bioinformatics Method to Predict Biological Activity from Biosynthetic Gene Clusters

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Lateral Gene Transfer Dynamics in the Ancient Bacterial Genus Streptomyces

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SANDPUMA: ensemble predictions of nonribosomal peptide chemistry reveal biosynthetic diversity across Actinobacteria

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Fungal Diversity in the Neptune Forest: Comparison of the Mycobiota of Posidonia oceanica, Flabellia petiolata, and Padina pavonica

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Cryptic or Silent? The Known Unknowns, Unknown Knowns, and Unknown Unknowns of Secondary Metabolism

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IMG-ABC v.5.0: an update to the IMG/Atlas of Biosynthetic Gene Clusters Knowledgebase

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Antibiotic production in Streptomyces is organized by a division of labor through terminal genomic differentiation

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Formation and diversification of a paradigm biosynthetic gene cluster in plants

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