Prunella vulgaris L., an Edible and Medicinal Plant, Attenuates Scopolamine-Induced Memory Impairment in Rats
Abstract
Prunella vulgaris L. is as a major plant in the Chinese traditional functional beverage Guangdong herbal tea for the treatment of fevers, diarrhea, and sore mouth. In this study, ethyl acetate parts of aqueous extracts from P. vulgaris L. (EtOAc-APV) were found to demonstrate potent acetylcholinesterase (AChE) inhibition in vitro. Therefore, this study was designed to further investigate the effects of EtOAc-APV on scopolamine (SCOP)-induced aging rats. Male Wistar rats were randomly divided into four groups (n = 12) and given orally by gavage EtOAc-APV (100 mg/kg) for 3 weeks. SCOP (1 mg/kg, ip) was administered to rats 30 min before starting behavioral tests consecutively for 3 days. EtOAc-APV could attenuate SCOP-induced brain senescence in rats by improving behavioral performance and decreasing brain cell damage, which was associated with a notable reduction in AChE activity and MDA level, as well as an increase in SOD and GPx activities. Additionally, EtOAc-APV administration could reduce the expression of NF-κB and GFAP, which showed an anti-neuroinflammatory effect on the SCOP-treated rat. Overall, the current study highlights P. vulgaris L. as an antidementia dietary supplement.
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Nine-Herb Decoction and Prunella vulgaris aqueous extract exhibited protective effects against scopolamine-induced memory impairments by inhibiting AChE activity.
“Nine-Herb Decoction, containing various plant extracts, and Prunella vulgaris aqueous extract have also exhibited protective effects against SCO-induced memory impairments by inhibiting AChE activity [62,63].”
From Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review (2025) · cites this paper as [63]
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- Authors
- Qu, Z., Zhang, J., Yang, H., Gao, J., Chen, H., Liu, C., & Gao, W.
- Affiliations
- Tianjin University (CN)
- Logistics University of People's Armed Police Force (CN)
- The State Key Laboratories of Pharmacodynamics and Pharmacokinetics, Tianjin 300193, China
- Corresponding author
- Gao, Wenyuan
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-01-03
- Volume
- 65
- Issue
- 2
- Pages
- 291-300
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2567321162
- Cited by
- 46
- References
- 34
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 5 · 2017: 3
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- China Postdoctoral Science Foundation (2015T81140)
- Logistics University of Chinese People's Armed Police Forces (WHB201509)
- Science and Technology Support Program Foundation of Tianjin (15CZDSY01020)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Prunella vulgaris, scopolamine-induced amnesia, acetylcholinesterase inhibition, neuroprotection, oxidative stress, neuroinflammation, NF-κB, glial fibrillary acidic protein, antioxidant enzymes, brain aging, ethyl acetate extract, aging rats
- MeSH terms
- Rosmarinic Acid, Animals, Caffeic Acids, Cholinesterase Inhibitors, Cinnamates, Flavonoids, Hippocampus, Male, Memory Disorders, Plant Extracts, Plants, Medicinal, Scopolamine, NF-kappa B, Rats, Wistar, Apoptosis, Neuroprotective Agents, Prunella, Depsides
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