Cited by 25Medicinal Plants and NeuroprotectionCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatments

Main plant extracts’active properties effective on scopolamine-induced memory loss

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Balmus, Ioana-Miruna, Ciobica, Alin·2017·American Journal of Alzheimer's Disease & Other Dementiasr

Abstract

Alzheimer's disease leads to progressive cognitive function loss, which may impair both intellectual capacities and psychosocial aspects. Although the current knowledge points to a multifactorial character of Alzheimer's disease, the most issued pathological hypothesis remains the cholinergic theory. The main animal model used in cholinergic theory research is the scopolamine-induced memory loss model. Although, in some cases, a temporary symptomatic relief can be obtained through targeting the cholinergic or glutamatergic neurotransmitter systems, no current treatment is able to stop or slow cognitive impairment. Many potentially successful therapies are often blocked by the blood-brain barrier since it exhibits permeability only for several classes of active molecules. However, the plant extracts' active molecules are extremely diverse and heterogeneous regarding the biochemical structure. In this way, many active compounds constituting the recently tested plant extracts may exhibit the same general effect on acetylcholine pathway, but on different molecular ground, which can be successfully used in Alzheimer's disease adjuvant therapy.

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Crossref · 10.1177/1533317517715906

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108 of 108 references verified0 citation errors · 0 not checkable

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Authors
Balmus, I.-M., & Ciobica, A.
Affiliations
  • Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University, Iasi, Romania
  • Alexandru Ioan Cuza University (RO)
Corresponding author
Ciobica, Alin
Venue
American Journal of Alzheimer's Disease & Other Dementiasr
Published
2017-06-23
Volume
32
Issue
7
Pages
418-428
ISSN
  • 0888-4897 (ISSN-L)
  • 1533-3175
  • 1938-2731
OpenAlex
W2658535994
Cited by
25
References
108
Citations by year
2026: 1 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 1
FWCI
0.23
Type
journal article
Language
en
Open access
Locations
  • American Journal of Alzheimer s Disease & Other Dementias® (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Romanian Government, Ministry of Education and Research (Research grant PN II PN-II-RU-TE-2014-4-1886)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
plant extracts, Alzheimer's disease, cognitive impairment, adjuvant therapy, blood-brain barrier
MeSH terms
Animals, Blood-Brain Barrier, Brain, Cognition, Disease Models, Animal, Humans, Memory Disorders, Plant Extracts, Scopolamine

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