Main plant extracts’active properties effective on scopolamine-induced memory loss
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Alzheimer's disease leads to progressive cognitive function loss, which may impair both intellectual capacities and psychosocial aspects. Although the current knowledge points to a multifactorial character of Alzheimer's disease, the most issued pathological hypothesis remains the cholinergic theory. The main animal model used in cholinergic theory research is the scopolamine-induced memory loss model. Although, in some cases, a temporary symptomatic relief can be obtained through targeting the cholinergic or glutamatergic neurotransmitter systems, no current treatment is able to stop or slow cognitive impairment. Many potentially successful therapies are often blocked by the blood-brain barrier since it exhibits permeability only for several classes of active molecules. However, the plant extracts' active molecules are extremely diverse and heterogeneous regarding the biochemical structure. In this way, many active compounds constituting the recently tested plant extracts may exhibit the same general effect on acetylcholine pathway, but on different molecular ground, which can be successfully used in Alzheimer's disease adjuvant therapy.
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Neuroprotective, anti-cerebral ischemic and antioxidative properties of various Jatanolides present in Nardostachys jatamansi may be the reason for its memory-enhancing activity.
“The neuroprotective, anti-cerebral ischemic and antioxidative properties of various Jatanolides present in the plant may be the reason for its memory-enhancing activity.”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [145]
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Microneedle-mediated nose-to-brain drug delivery for improved Alzheimer's disease treatment
Ruan, S., Li, J., Ruan, H., Xia, Q., Hou, X. L., Wang, Z., Guo, T., Zhu, C., Feng, N., & Zhang, Y. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.01.013 · Cited by 113 · see citing works
Arya, A., Chahal, R., Rao, R., Rahman, M. H., Kaushik, D., Akhtar, M. F., Saleem, A., Khalifa, S. M. A., El-Seedi, H. R., Kamel, M., et al. (2021) · Biomolecules · doi:10.3390/biom11030350 · Cited by 111 · see citing works
Plant Fortification of the Diet for Anti-Ageing Effects: A Review
Dhanjal, D. S., Bhardwaj, S., Sharma, R., Bhardwaj, K., Kumar, D., Chopra, C., Nepovimová, E., Singh, R., & Kuča, K. (2020) · Nutrients · doi:10.3390/nu12103008 · Cited by 55 · see citing works
Ginseng gintonin, aging societies, and geriatric brain diseases
Choi, S.-H., Lee, R., Nam, S. M., Kim, D.-G., Cho, I., Kim, H., Cho, Y., Rhim, H., & Nah, S.-Y. (2020) · Integrative Medicine Research · doi:10.1016/j.imr.2020.100450 · Cited by 51 · see citing works
Mansouri, F., Ghanbari, H., Marefati, N., Arab, Z., Salmani, H., Beheshti, F., & Hosseini, M. (2021) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-021-02062-w · Cited by 41 · see citing works
Ellagic Acid: A Dietary-Derived Phenolic Compound for Drug Discovery in Mild Cognitive Impairment
Wang, W., Wang, S., Liu, Y., Wang, X., Nie, J., Meng, X., & Zhang, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.925855 · Cited by 33 · see citing works
Anti-Aging Effect of Traditional Plant-Based Food: An Overview
Das, G., Kameswaran, S., Ramesh, B., Manjunatha, B., Nath, R., Talukdar, A. D., Shin, H., & Patra, J. K. (2024) · Foods · doi:10.3390/foods13233785 · Cited by 33 · see citing works
Shevtsova, E. F., Angelova, P. R., Stelmashchuk, O. A., Esteras, N., Васильева, Н. А., Maltsev, A. V., Shevtsov, P. N., Shaposhnikov, A. V., Фисенко, В. П., Бачурин, С. О., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-16817-9 · Cited by 24 · see citing works
Learning about Science & Pseudoscience as Critical Consumers
Beer, J. J. D., & Wyk, B.-E. V. (2022) · The American Biology Teacher · doi:10.1525/abt.2022.84.8.488 · Cited by 16 · see citing works
S, G. S., Raghu, C. H., & Fayaz, S. M. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210920120612 · Cited by 13 · see citing works
Helmi, H., Fakhrudin, N., Nurrochmad, A., & Ikawati, Z. (2021) · Scientia Pharmaceutica · doi:10.3390/scipharm89020029 · Cited by 11 · see citing works
Enogieru, A. B., & Omoruyi, S. I. (2022) · Journal of applied science and environmental management · doi:10.4314/jasem.v26i4.10 · Cited by 11 · see citing works
Xie, Y., Liu, L., Zheng, J., Shi, K., Ai, W., Zhang, X., Wang, P., Lan, Z., & Chen, L. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116400 · Cited by 11 · see citing works
Effects of Oxytocin Administration on Oxidative Markers in the Temporal Lobe of Aged Rats
Balmuș, I.-M., Ciobica, A. S., Stoica, B. A., Lefter, R. M., Cojocaru, S., & Резніков, А. Г. (2019) · Neurophysiology · doi:10.1007/s11062-019-09785-w · Cited by 11 · see citing works
Plant natural products for cognitive impairment: A review of the preclinical evidence
Helmi, H., Fakhrudin, N., Nurrochmad, A., & Zullies, I. (2021) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2021.110601 · Cited by 9 · see citing works
The Quest for Neurodegenerative Disease Treatment—Focusing on Alzheimer’s Disease Personalised Diets
Palimariciuc, M., Balmuș, I.-M., Gireadă, B., Ciobica, A. S., Chiriță, R., Iordache, A.-C., Apostu, M., & Dobrin, R. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45020098 · Cited by 9 · see citing works
Brinza, I., Boiangiu, R. Ş., Bağcı, E., Todirașcu-Ciornea, E., Hriţcu, L., & Dumitru, G. (2025) · Scientific Reports · doi:10.1038/s41598-025-22125-9 · Cited by 6 · see citing works
Nain, P., Kumar, S., Bhatia, M., & Kaur, J. (2021) · Journal of Reports in Pharmaceutical Sciences · doi:10.4103/jrptps.jrptps_22_21 · Cited by 4 · see citing works
Preventive Role of Nutraceutical Agents Against Aging
Jayasree, R., Thangam, C., Kulanthaivel, L., & Subbaraj, G. K. (2023) · Springer eBooks · doi:10.1007/978-981-99-0534-8_18 · Cited by 2 · see citing works
Suv39h1 Silencing Recovers Memory Decline in Scopolamine-Induced Amnesic Mouse Model
Kushwaha, A., & Thakur, M. K. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03570-x · Cited by 2 · see citing works
Adeyemo, S. A., Ajao, M. Y., Ogundeyi, K. J., Femi-Akinlosotu, O., & Bakre, A. G. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118731 · Cited by 2 · see citing works
Toledano, J. V., González, I. G., Pacheco‐Yépez, J., Correa‐Basurto, J., & Rosales‐Hernández, M. C. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052241 · Cited by 1 · see citing works
Protocol Development and Optimization for rNLS Mouse Characteristic Assessment
Farid, H. (2020) · Journal of Bioresource Management
Adeyemo, S. A., Ajao, M. Y., Ogundeyi, K. J., Femi-Akinlosotu, O. M., & Bakre, A. G. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4902113
EXPERIMENTAL ALZHEIMER’S DISEASE IN DIFFERENT ANIMAL MODELS
(2024) · International Journal of Biology Pharmacy and Allied Sciences · doi:10.31032/ijbpas/2024/13.9.8311
- Authors
- Balmus, I.-M., & Ciobica, A.
- Affiliations
- Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University, Iasi, Romania
- Alexandru Ioan Cuza University (RO)
- Corresponding author
- Ciobica, Alin
- ORCID
- Ciobica, Alin
- Venue
- American Journal of Alzheimer's Disease & Other Dementiasr
- Publisher
- SAGE Publications
- Published
- 2017-06-23
- Volume
- 32
- Issue
- 7
- Pages
- 418-428
- ISSN
- 0888-4897 (ISSN-L)
- 1533-3175
- 1938-2731
- PMC
- PMC10852862
- OpenAlex
- W2658535994
- Cited by
- 25
- References
- 108
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 1
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- American Journal of Alzheimer s Disease & Other Dementias® (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Romanian Government, Ministry of Education and Research (Research grant PN II PN-II-RU-TE-2014-4-1886)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- plant extracts, Alzheimer's disease, cognitive impairment, adjuvant therapy, blood-brain barrier
- MeSH terms
- Animals, Blood-Brain Barrier, Brain, Cognition, Disease Models, Animal, Humans, Memory Disorders, Plant Extracts, Scopolamine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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