Asiaticoside Mitigates the Allergic Inflammation by Abrogating the Degranulation of Mast Cells
Abstract
The effects of asiaticoside (AS) on allergic responses mediated by mast cells were investigated. AS showed no obvious cytotoxicity on RPMCs (rat peritoneal mast cells). AS reduced the intracellular calcium in RPMCs and deprived the histamine release and degranulation. AS also decreased the generation of antigen-induced tumor necrosis factor α, interleukin (IL)-4, IL-8, and IL-1β in RBL-2H3 cells sensitized by IgE. The suppression of AS on pro-inflammatory cytokines was related with the activation of the intracellular FcεRI and the inhibition of the nuclear factor-κB signaling pathway. In addition, AS disabled the phosphorylation of antigen-induced Syk, Lyn, Gab2, and PLCγ1, thus suppressing the downstream Akt phosphorylation and MAPKs pathways. It also increased HO-1 and Nrf2 expression time dependently. In summary, we demonstrate that AS suppresses the allergic inflammation mediated by mast cells and this effect might be mediated by FcεRI-dependent signaling pathways.
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Asiaticoside suppresses allergic inflammation by blocking histamine release and mitigating mast cell degranulation, as well as reducing generation of antigen-induced inflammatory factors, via FcεRI-dependent signalling pathways.
“Asiaticoside can suppress allergic inflammation by blocking histamine release and mitigating mast cell degranulation, as well as reducing the generation of antigen‐induced inflammatory factors, via the FcεRI‐dependent signalling pathways.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [142]
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NRF2 as a Therapeutic Target in Neurodegenerative Diseases
Brandes, M. S., & Gray, N. E. (2020) · ASN Neuro · doi:10.1177/1759091419899782 · Cited by 297 · see citing works
Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review
Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N. K., Kumar, M., Radha, Ghosh, A., Proćków, J., Pérez de la Lastra, J. M., & Dey, A. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17635 · Cited by 220 · see citing works
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Feng, X., Huang, D., Lin, D., Zhu, L., Zhang, M., Chen, Y., & Wu, F. (2021) · Journal of Investigative Surgery · doi:10.1080/08941939.2019.1584255 · Cited by 23 · see citing works
- Authors
- Jiang, J. Z., Ye, J., Jin, G. Y., Piao, H. M., Cui, H., Zheng, M. Y., Yang, J. S., Che, N., Choi, Y. H., Li, L. C., & Yan, G. H.
- Affiliations
- Yanbian University (CN)
- Yanbian University Hospital (CN)
- Jeonbuk National University (KR)
- Corresponding author
- Li, Liang Chang
- Yan, Guang Hai
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-09-11
- Volume
- 65
- Issue
- 37
- Pages
- 8128-8135
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2756351814
- Cited by
- 31
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 8 · 2019: 4 · 2018: 2
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81260016, 81560004, 81560679)
- Jilin Province (20140519013JH)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- asiaticoside, mast cell degranulation, allergic inflammation, FcεRI signaling, intracellular calcium, histamine release, inflammatory cytokines, NF-κB signaling, Syk phosphorylation, MAPK signaling, Akt signaling, Nrf2/HO-1 pathway, RBL-2H3 cells, IgE sensitization
- MeSH terms
- Animals, Cells, Cultured, Histamine Release, Hypersensitivity, Immunoglobulin E, Male, Mast Cells, Mice, Inbred BALB C, Phosphorylation, Triterpenes, Signal Transduction, Cell Degranulation, Interleukin-8, NF-kappa B, Rats, Sprague-Dawley, Mice, Rats
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