The DOI matches its Crossref record; 205 of the 205 references it cites were found in a registry or an index.
The Medicinal Chemistry of Therapeutic Oligonucleotides
Abstract
Oligonucleotide-based therapeutics have made rapid progress in the clinic for treatment of a variety of disease indications. Unmodified oligonucleotides are polyanionic macromolecules with poor drug-like properties. Over the past two decades, medicinal chemists have identified a number of chemical modification and conjugation strategies which can improve the nuclease stability, RNA-binding affinity, and pharmacokinetic properties of oligonucleotides for therapeutic applications. In this perspective, we present a summary of the most commonly used nucleobase, sugar and backbone modification, and conjugation strategies used in oligonucleotide medicinal chemistry.
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Metadata
- Authors
- Wan, W. B., & Seth, P. P.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-07-29
- Volume
- 59
- Issue
- 21
- Pages
- 9645-9667
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2481500357
- Cited by
- 429
- References
- 205
- FWCI
- 13.84
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
