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Cited by 7,570

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Fluorine in medicinal chemistry

Purser, Sophie, Moore, Peter R., Swallow, Steve, Gouverneur, Véronique·2008·Chem. Soc. Rev.
DOI 10.1039/b610213c
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Abstract

It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.

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Research works printed but not linked: 40

  1. Wong, 1995, Life Sci., 57, 411, 10.1016/0024-3205(95)00209-O · DOI · Paper page
  2. Roman, 2003, Eur. J. Pharmacol., 479, 53, 10.1016/j.ejphar.2003.08.056 · doi:10.1016/j.ejphar.2003.08.056
  3. Robertson, 2005, Eur. J. Cancer, 41, 346, 10.1016/j.ejca.2004.07.035 · doi:10.1016/j.ejca.2004.07.035
  4. Mabe, 2004, Curr. Microbiol., 49, 248, 10.1007/s00284-004-4312-9 · DOI
  5. Fera, 2001, Int. J. Antimicrob. Agents, 17, 151, 10.1016/S0924-8579(00)00315-0 · DOI
  6. Plosker, 2001, PharmacoEconomics, 19, 421, 10.2165/00019053-200119040-00009 · DOI
  7. Adkins, 1998, Drugs, 56, 1055, 10.2165/00003495-199856060-00014 · doi:10.2165/00003495-199856060-00014
  8. Rabel, 2001, AAPS PharmSci, 3, 1, 10.1208/ps030428 · doi:10.1208/ps030428
  9. D. A. Smith , H.van de Waterbeemd and D. K.Walker, Methods and Principles in Medicinal Chemistry, vol. 31: Pharmacokinetics and Metabolism in Drug Design, Wiley-VCH, Weinheim, 2006 · DOI
  10. R. D. Chambers , Fluorine in Organic Chemistry, Blackwell Publishing, Oxford, 2000
  11. Morgenthaler, 2007, ChemMedChem, 2, 1100, 10.1002/cmdc.200700059 · DOI · Paper page
  12. Rowley, 2001, J. Med. Chem., 44, 1603, 10.1021/jm0004998 · DOI
  13. Van Niel, 1999, J. Med. Chem., 42, 2087, 10.1021/jm981133m · doi:10.1021/jm981133m
  14. Lipinski, 1997, Adv. Drug Delivery Rev., 23, 3, 10.1016/S0169-409X(96)00423-1 · DOI · Paper page
  15. Smart, 2001, J. Fluorine Chem., 109, 3, 10.1016/S0022-1139(01)00375-X · DOI · Paper page
  16. Jacobs, 1994, J. Med. Chem., 37, 1282, 10.1021/jm00035a008 · doi:10.1021/jm00035a008
  17. Müller, 2007, Science, 317, 1881, 10.1126/science.1131943 · DOI · Paper page
  18. Massa, 2001, Bioorg. Med. Chem. Lett., 11, 1625, 10.1016/S0960-894X(01)00244-X · doi:10.1016/s0960-894x(01)00244-x
  19. Myers, 2001, J. Am. Chem. Soc., 123, 7207, 10.1021/ja010113y · DOI
  20. Muller, 1986, J. Pharm. Sci., 75, 987, 10.1002/jps.2600751016 · doi:10.1002/jps.2600751016
  21. Cantacuzene, 1979, Science, 204, 1217, 10.1126/science.221978 · DOI
  22. Olsen, 2004, ChemBioChem, 5, 666, 10.1002/cbic.200300907 · DOI
  23. Rosenblum, 1998, J. Med. Chem., 41, 973, 10.1021/jm970701f · DOI · Paper page
  24. Van Heek, 1997, J. Pharmacol. Exp. Ther., 283, 157, 10.1016/S0022-3565(24)36992-7 · DOI · Paper page
  25. Chauret, 2002, Bioorg. Med. Chem. Lett., 12, 2149, 10.1016/S0960-894X(02)00349-9 · DOI
  26. Cho, 1978, Prostaglandins, 15, 943, 10.1016/0090-6980(78)90037-0 · DOI · Paper page
  27. Bannai, 1983, Tetrahedron, 39, 3807, 10.1016/S0040-4020(01)88623-3 · doi:10.1016/s0040-4020(01)88623-3
  28. Chang, 1997, Prostaglandins, 53, 83, 10.1016/S0090-6980(97)00003-8 · doi:10.1016/s0090-6980(97)00003-8
  29. Eriksson, 1995, Chirality, 7, 44, 10.1002/chir.530070109 · DOI · Paper page
  30. Takeuchi, 1999, Org. Lett., 1, 1571, 10.1021/ol9902172 · DOI
  31. Santi, 1971, Biochemistry, 10, 3598, 10.1021/bi00795a018 · DOI
  32. Barrett, 1998, J. Am. Chem. Soc., 120, 449, 10.1021/ja973210t · doi:10.1021/ja973210t
  33. Malet-Martino, 2002, Curr. Med. Chem.: Anti-Cancer Agents, 2, 267
  34. Park, 2001, Annu. Rev. Pharmacol. Toxicol., 41, 443, 10.1146/annurev.pharmtox.41.1.443 · DOI · Paper page
  35. Barchi, Jr., 1997, J. Biochem. Biophys. Methods, 34, 11, 10.1016/S0165-022X(96)00032-2 · doi:10.1016/s0165-022x(96)00032-2
  36. Koshida, 1989, Antimicrob. Agents Chemother., 33, 2083, 10.1128/AAC.33.12.2083 · DOI
  37. M. J. Welch and C. S.Redvanly, Handbook of Radiopharmaceuticals, Radiochemistry and Applications, Wiley & Sons Ltd, England, 2003
  38. Beuthien-Baumann, 2000, Carbohydr. Res., 327, 107, 10.1016/S0008-6215(00)00030-6 · doi:10.1016/s0008-6215(00)00030-6
  39. Cunningham, 2005, Drug Discovery Today: Technol., 2, 311, 10.1016/j.ddtec.2005.11.003 · doi:10.1016/j.ddtec.2005.11.003
  40. Bergström, 2004, Biol. Psychiatry, 55, 1007, 10.1016/j.biopsych.2004.02.007 · DOI

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Metadata

Authors
Purser, S., Moore, P. R., Swallow, S., & Gouverneur, V.
Venue
Chem. Soc. Rev.
Publisher
Royal Society of Chemistry (RSC)
Published
2008
Volume
37
Issue
2
Pages
320-330
ISSN
  • 0306-0012 (ISSN-L)
  • 1460-4744
DOI
10.1039/b610213c
OpenAlex
W2116087305
Cited by
7,570
References
5
FWCI
4.40
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Fluorine in medicinal chemistry. https://app.cochat.ai/papers/10.1039/b610213c
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Purser, S., Moore, P. R., Swallow, S., & Gouverneur, V. (2008). Fluorine in medicinal chemistry. Chem. Soc. Rev. https://doi.org/10.1039/b610213c

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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