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Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors

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Design of Chemically Stable, Potent, and Efficacious MDM2 Inhibitors That Exploit the Retro-Mannich Ring-Opening-Cyclization Reaction Mechanism in Spiro-oxindoles

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Phosphine Organocatalysis for the Synthesis of Spirocyclic Compounds

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Reactivation of p53 by MDM2 Inhibitor MI-77301 for the Treatment of Endocrine-Resistant Breast Cancer

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Synthesis of a Spiroindolinone Pyrrolidinecarboxamide MDM2 Antagonist

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The Frequent Application of Multicomponent and Cycloaddition Reactions for the Synthesis of Potent MDM2-p53 Inhibitors

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Recent advances in phosphine catalysis involving γ-substituted allenoates

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Synthesis of Seleno Oxindoles via Electrochemical Cyclization of N ‐arylacrylamides with Diorganyl Diselenides

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Electrochemical difunctionalization of alkenes and alkynes for the synthesis of organochalcogens involving C–S/Se bond formation

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Construction of spirooxindole-fused spiropyrazolones containing contiguous three stereogenic centres via [3 + 2] annulation utilizing a ferrocene derived bifunctional phosphine catalyst

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Copper( i )/Ganphos catalysis: enantioselective synthesis of diverse spirooxindoles using iminoesters and alkyl substituted methyleneindolinones

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Recent Advances in Nucleophilic Lewis Base‐Catalyzed Cycloadditions for Synthesis of Spirooxindoles

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Targeted Synthesis of Complex Spiro[3 H ‐indole‐3,2′‐pyrrolidin]‐2(1 H )‐ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2–p53 Inhibitors

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Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells

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Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents

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Organo/Silver Dual Catalytic (3 + 2)/Conia-Ene Type Cyclization: Asymmetric Synthesis of Indane-Fused Spirocyclopenteneoxindoles

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Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein–Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy

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Recent Advancements in the Discovery of MDM2/MDM2-p53 Interaction Inhibitors for the Treatment of Cancer

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Zinc-Catalyzed Enantioselective [3 + 3] Annulation for Synthesis of Chiral Spiro[indoline-3,4′-thiopyrano[2,3-b]indole] Derivatives

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An Efficient Route to Access Spirooxindole–Pyrazolone-Fused Cyclopentenes by a Diastereoselective [3+2] Annulation

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Synthesis and Antitumor Activity of a Series of Novel 1-Oxa-4-azaspiro[4,5]deca-6,9-diene-3,8-dione Derivatives

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Highly regio- and stereoselective (3 + 2) annulation reaction of allenoates with 3-methyleneindolin-2-ones catalyzed by a planar chiral [2.2]paracyclophane-based bifunctional phosphine–phenol catalyst

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Medicinal applications of spirooxindole and its derivatives

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Pd/Cu Synergistic Catalysis for Difluorocarbene-Mediated Synthesis of Carbamoyl-Substituted Oxindoles

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BindingDB Entry 50018627: Evolution in non-peptide α-helix mimetics on the road to effective protein-protein interaction modulators.

BindingDB (2024) · UC San Diego · doi:10.7270/q2kp86dp

BindingDB Entry 50020573: Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy.

BindingDB (2024) · UC San Diego · doi:10.7270/q2765ktj

BindingDB Entry 50007847: Development of selective small molecule MDM2 degraders based on nutlin.

BindingDB (2021) · UC San Diego · doi:10.7270/q22j6g6h

BindingDB Entry 50017816: Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells.

BindingDB (2023) · UC San Diego · doi:10.7270/q2v69pp3

Unlocking the Anticancer Potential of New Spirooxindoles via p53‐MDM2/MDMX Dual Inhibition: In Vitro and In Silico Assessments

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One-Pot Synthesis of spiro(indoline-3,4′-pyrazolo[3,4-b]pyridine)-5′-carbonitriles As p53-MDM2 Interaction Inhibitors

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Synthesis of Spiro-oxindole MDM2 Inhibitors

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